Tivozanib - Small Molecule (ID:10005-101)

HMS LINCS ID: 10005-101
Name: Tivozanib
Alternative Names: AV-951
LINCS ID: LSM-1005
PubChem CID: 9911830
ChEBI ID:
ChEMBL ID:
Molecular Mass: 454.10
InChi: InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)
InChi Key: SPMVMDHWKHCIDT-UHFFFAOYSA-N
SMILES: CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
EPHB2, FLT1, FLT4, KDR, PDGFRA
2
(equivalent to 100 nM ≤ Kd < 1µM)
KIT, PDGFRB

Batch Information for HMSL10005-101-1:

HMS LINCS Batch ID: 10005-101-1
Provider: Haoyuan chemexpress
Provider Batch ID: HY-999-20101221
Salt: 101
Molecular Formula: C22H19ClN4O5
Molecular Weight: 454.86
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2011-07-15
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10005-101-1:

Date HMS QC Outcome Comment Files
03/13/2015 PASS HMSL10005-101-1_LCMS.pdf
02/22/2011 PASS None