Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SUM149PT INK-128
1.0
mTORC1/2
PI3K/mTOR
 0.3827 0.02423
SUM149PT INK-128
3.1623
mTORC1/2
PI3K/mTOR
 0.2613 0.03984
SUM149PT PF-4708671
0.001
p70S6K
PI3K/mTOR
 1.0001 0.00313
SUM149PT PF-4708671
0.0031623
p70S6K
PI3K/mTOR
 1.0301 0.00412
SUM149PT PF-4708671
0.01
p70S6K
PI3K/mTOR
 0.9983 0.00190
SUM149PT PF-4708671
0.031623
p70S6K
PI3K/mTOR
 1.0211 0.00287
SUM149PT PF-4708671
0.1
p70S6K
PI3K/mTOR
 1.0254 0.00056
SUM149PT PF-4708671
0.31623
p70S6K
PI3K/mTOR
 0.9981 0.00035
SUM149PT PF-4708671
1.0
p70S6K
PI3K/mTOR
 0.9464 0.00130
SUM149PT PF-4708671
3.1623
p70S6K
PI3K/mTOR
 0.9238 0.00901
SUM149PT PF-4708671
10.0
p70S6K
PI3K/mTOR
 0.7287 0.05770
SUM149PT Buparlisib
0.001
pan PI3K
PI3K/mTOR
 1.0168 0.00438
SUM149PT Buparlisib
0.0031623
pan PI3K
PI3K/mTOR
 1.0092 0.00048
SUM149PT Buparlisib
0.01
pan PI3K
PI3K/mTOR
 1.0053 0.00200
SUM149PT Buparlisib
0.031623
pan PI3K
PI3K/mTOR
 1.0087 0.00011
SUM149PT Buparlisib
0.1
pan PI3K
PI3K/mTOR
 0.9676 0.00133
SUM149PT Buparlisib
0.31623
pan PI3K
PI3K/mTOR
 0.9572 0.00066
SUM149PT Buparlisib
1.0
pan PI3K
PI3K/mTOR
 0.6886 0.05795
SUM149PT Buparlisib
3.1623
pan PI3K
PI3K/mTOR
 -0.0082 0.40816
SUM149PT Buparlisib
10.0
pan PI3K
PI3K/mTOR
 -0.3357 0.61916
SUM149PT Pictilisib
0.001
pan PI3K
PI3K/mTOR
 1.0283 0.00091
SUM149PT Pictilisib
0.0031623
pan PI3K
PI3K/mTOR
 1.0100 0.00021
SUM149PT Pictilisib
0.01
pan PI3K
PI3K/mTOR
 0.9730 -0.00185
SUM149PT Pictilisib
0.031623
pan PI3K
PI3K/mTOR
 1.0151 -0.00455
SUM149PT Pictilisib
0.1
pan PI3K
PI3K/mTOR
 0.9689 -0.00041