Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 1 1239 114 0.3246 0.2591 0.0920 0.0924
MZ7-mel Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 2 1016 94 0.2660 0.2591 0.0925 0.0924
MZ7-mel Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 3 713 66 0.1867 0.2591 0.0926 0.0924
MZ7-mel Vemurafenib PF562271 3.160 0.000
uM
 72
hr
 1 1194 304 0.2568 0.3102 0.2546 0.2845
MZ7-mel Vemurafenib PF562271 3.160 0.000
uM
 72
hr
 2 1597 449 0.3312 0.3102 0.2812 0.2845
MZ7-mel Vemurafenib PF562271 3.160 0.000
uM
 72
hr
 3 1741 553 0.3427 0.3102 0.3176 0.2845
MZ7-mel Vemurafenib PF562271 3.160 0.316
uM
 72
hr
 1 585 88 0.1434 0.1862 0.1504 0.1658
MZ7-mel Vemurafenib PF562271 3.160 0.316
uM
 72
hr
 2 878 144 0.2118 0.1862 0.1640 0.1658
MZ7-mel Vemurafenib PF562271 3.160 0.316
uM
 72
hr
 3 863 158 0.2034 0.1862 0.1831 0.1658
MZ7-mel Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 1 1771 249 0.4391 0.3063 0.1406 0.1700
MZ7-mel Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 2 1364 241 0.3240 0.3063 0.1767 0.1700
MZ7-mel Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 3 669 129 0.1558 0.3063 0.1928 0.1700
MZ7-mel Vemurafenib PF562271 3.160 3.160
uM
 72
hr
 1 925 144 0.2253 0.1873 0.1557 0.1549
MZ7-mel Vemurafenib PF562271 3.160 3.160
uM
 72
hr
 2 729 119 0.1760 0.1873 0.1632 0.1549
MZ7-mel Vemurafenib PF562271 3.160 3.160
uM
 72
hr
 3 652 95 0.1607 0.1873 0.1457 0.1549
MZ7-mel Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 1 3049 224 0.9214 1.0000 0.0735 0.0654
MZ7-mel Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 2 3491 225 1.0652 1.0000 0.0645 0.0654
MZ7-mel Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 3 3299 192 1.0134 1.0000 0.0582 0.0654
MZ7-mel Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 1 2761 200 0.8353 1.4168 0.0724 0.0618
MZ7-mel Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 2 4806 288 1.4736 1.4168 0.0599 0.0618
MZ7-mel Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 3 6287 334 1.9416 1.4168 0.0531 0.0618
MZ7-mel Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 1 2708 151 0.8340 0.7361 0.0558 0.0573
MZ7-mel Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 2 2625 125 0.8154 0.7361 0.0476 0.0573
MZ7-mel Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 3 1840 126 0.5590 0.7361 0.0685 0.0573
MZ7-mel Vemurafenib Saracatinib 0.000 3.160
uM
 72
hr
 1 4872 354 1.4736 0.9734 0.0727 0.0805