Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib PF562271 0.100 1.000
uM
 72
hr
 3 1548 86 0.4218 0.6073 0.0556 0.0523
MZ7-mel Vemurafenib PF562271 0.100 3.160
uM
 72
hr
 1 1962 107 0.5351 0.4191 0.0545 0.0616
MZ7-mel Vemurafenib PF562271 0.100 3.160
uM
 72
hr
 2 1617 91 0.4402 0.4191 0.0563 0.0616
MZ7-mel Vemurafenib PF562271 0.100 3.160
uM
 72
hr
 3 1055 78 0.2819 0.4191 0.0739 0.0616
MZ7-mel Vemurafenib PF562271 0.316 0.000
uM
 72
hr
 1 1598 96 0.4333 0.5367 0.0601 0.0669
MZ7-mel Vemurafenib PF562271 0.316 0.000
uM
 72
hr
 2 2275 142 0.6153 0.5367 0.0624 0.0669
MZ7-mel Vemurafenib PF562271 0.316 0.000
uM
 72
hr
 3 2111 165 0.5614 0.5367 0.0782 0.0669
MZ7-mel Vemurafenib PF562271 0.316 0.316
uM
 72
hr
 1 1900 105 0.5178 0.5749 0.0553 0.0526
MZ7-mel Vemurafenib PF562271 0.316 0.316
uM
 72
hr
 2 2177 113 0.5954 0.5749 0.0519 0.0526
MZ7-mel Vemurafenib PF562271 0.316 0.316
uM
 72
hr
 3 2232 113 0.6113 0.5749 0.0506 0.0526
MZ7-mel Vemurafenib PF562271 0.316 1.000
uM
 72
hr
 1 2285 94 0.6321 0.4655 0.0411 0.0405
MZ7-mel Vemurafenib PF562271 0.316 1.000
uM
 72
hr
 2 1741 82 0.4786 0.4655 0.0471 0.0405
MZ7-mel Vemurafenib PF562271 0.316 1.000
uM
 72
hr
 3 1025 34 0.2859 0.4655 0.0332 0.0405
MZ7-mel Vemurafenib PF562271 0.316 3.160
uM
 72
hr
 1 1353 87 0.3652 0.3125 0.0643 0.0644
MZ7-mel Vemurafenib PF562271 0.316 3.160
uM
 72
hr
 2 1387 78 0.3776 0.3125 0.0562 0.0644
MZ7-mel Vemurafenib PF562271 0.316 3.160
uM
 72
hr
 3 728 53 0.1947 0.3125 0.0728 0.0644
MZ7-mel Vemurafenib PF562271 1.000 0.000
uM
 72
hr
 1 1404 173 0.3551 0.4243 0.1232 0.1334
MZ7-mel Vemurafenib PF562271 1.000 0.000
uM
 72
hr
 2 1852 251 0.4619 0.4243 0.1355 0.1334
MZ7-mel Vemurafenib PF562271 1.000 0.000
uM
 72
hr
 3 1840 260 0.4558 0.4243 0.1413 0.1334
MZ7-mel Vemurafenib PF562271 1.000 0.316
uM
 72
hr
 1 1150 122 0.2966 0.3680 0.1061 0.0865
MZ7-mel Vemurafenib PF562271 1.000 0.316
uM
 72
hr
 2 1413 126 0.3713 0.3680 0.0892 0.0865
MZ7-mel Vemurafenib PF562271 1.000 0.316
uM
 72
hr
 3 1616 104 0.4362 0.3680 0.0644 0.0865
MZ7-mel Vemurafenib PF562271 1.000 1.000
uM
 72
hr
 1 1888 167 0.4965 0.3742 0.0885 0.0960
MZ7-mel Vemurafenib PF562271 1.000 1.000
uM
 72
hr
 2 1496 141 0.3909 0.3742 0.0943 0.0960
MZ7-mel Vemurafenib PF562271 1.000 1.000
uM
 72
hr
 3 911 96 0.2351 0.3742 0.1054 0.0960