Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 1 395 154 0.2440 0.2143 0.3899 0.4559
MMAC-SF Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 2 403 187 0.2187 0.2143 0.4640 0.4559
MMAC-SF Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 3 366 188 0.1802 0.2143 0.5137 0.4559
MMAC-SF Vemurafenib PF562271 3.160 0.000
uM
 72
hr
 1 537 167 0.3746 0.3743 0.3110 0.3533
MMAC-SF Vemurafenib PF562271 3.160 0.000
uM
 72
hr
 2 538 203 0.3392 0.3743 0.3773 0.3533
MMAC-SF Vemurafenib PF562271 3.160 0.000
uM
 72
hr
 3 643 239 0.4090 0.3743 0.3717 0.3533
MMAC-SF Vemurafenib PF562271 3.160 0.316
uM
 72
hr
 1 290 89 0.2035 0.2184 0.3069 0.3304
MMAC-SF Vemurafenib PF562271 3.160 0.316
uM
 72
hr
 2 356 103 0.2562 0.2184 0.2893 0.3304
MMAC-SF Vemurafenib PF562271 3.160 0.316
uM
 72
hr
 3 319 126 0.1954 0.2184 0.3950 0.3304
MMAC-SF Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 1 517 195 0.3260 0.2379 0.3772 0.3676
MMAC-SF Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 2 342 114 0.2308 0.2379 0.3333 0.3676
MMAC-SF Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 3 255 100 0.1569 0.2379 0.3922 0.3676
MMAC-SF Vemurafenib PF562271 3.160 3.160
uM
 72
hr
 1 250 98 0.1539 0.1255 0.3920 0.4181
MMAC-SF Vemurafenib PF562271 3.160 3.160
uM
 72
hr
 2 191 77 0.1154 0.1255 0.4031 0.4181
MMAC-SF Vemurafenib PF562271 3.160 3.160
uM
 72
hr
 3 196 90 0.1073 0.1255 0.4592 0.4181
MMAC-SF Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 1 1135 66 0.8529 1.0000 0.0581 0.0496
MMAC-SF Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 2 1504 69 1.1449 1.0000 0.0459 0.0496
MMAC-SF Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 3 1315 59 1.0021 1.0000 0.0449 0.0496
MMAC-SF Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 1 1511 68 1.1513 1.3011 0.0450 0.0459
MMAC-SF Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 2 1771 79 1.3500 1.3011 0.0446 0.0459
MMAC-SF Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 3 1846 89 1.4019 1.3011 0.0482 0.0459
MMAC-SF Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 1 1386 59 1.0588 0.8133 0.0426 0.0417
MMAC-SF Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 2 956 43 0.7285 0.8133 0.0450 0.0417
MMAC-SF Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 3 850 32 0.6527 0.8133 0.0376 0.0417
MMAC-SF Vemurafenib Saracatinib 0.000 3.160
uM
 72
hr
 1 1325 58 1.0109 0.8059 0.0438 0.0432