Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 0.533 | uM | 7436.091 | 1.0262 | 1.0418 | 1.2489 | |
| HCC1395 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 2.67 | uM | 7436.091 | 0.9943 | 0.9909 | 1.2489 | |
| HCC1395 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 13.3 | uM | 7436.091 | 0.9027 | 0.8427 | 1.2489 | |
| HCC1395 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 66.7 | uM | 7436.091 | 0.7459 | 0.5816 | 1.2489 | |
| HCC1419 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 0.000171 | uM | 7437.091 | 1.0750 | 1.4714 | 0.3419 | |
| HCC1419 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 0.000853 | uM | 7437.091 | 1.0339 | 1.2047 | 0.3419 | |
| HCC1419 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 0.00427 | uM | 7437.091 | 0.9706 | 0.8330 | 0.3419 | |
| HCC1419 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 0.0213 | uM | 7437.091 | 1.0352 | 1.2131 | 0.3419 | |
| HCC1419 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 0.107 | uM | 7437.091 | 1.0489 | 1.2996 | 0.3419 | |
| HCC1419 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 0.533 | uM | 7437.091 | 1.0087 | 1.0513 | 0.3419 | |
| HCC1419 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 2.67 | uM | 7437.091 | 1.0512 | 1.3144 | 0.3419 | |
| HCC1419 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 13.3 | uM | 7437.091 | 0.9092 | 0.5139 | 0.3419 | |
| HCC1419 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 66.7 | uM | 7437.091 | 0.6926 | -0.3169 | 0.3419 | |
| HCC1419 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 0.000171 | uM | 7440.091 | 1.0178 | 1.0850 | 0.4250 | |
| HCC1419 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 0.000853 | uM | 7440.091 | 0.9546 | 0.7926 | 0.4250 | |
| HCC1419 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 0.00427 | uM | 7440.091 | 1.0079 | 1.0374 | 0.4250 | |
| HCC1419 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 0.0213 | uM | 7440.091 | 0.9997 | 0.9988 | 0.4250 | |
| HCC1419 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 0.107 | uM | 7440.091 | 0.9523 | 0.7828 | 0.4250 | |
| HCC1419 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 0.533 | uM | 7440.091 | 1.0277 | 1.1328 | 0.4250 | |
| HCC1419 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 2.67 | uM | 7440.091 | 0.9724 | 0.8727 | 0.4250 | |
| HCC1419 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 13.3 | uM | 7440.091 | 0.7445 | -0.0010 | 0.4250 | |
| HCC1419 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 66.7 | uM | 7440.091 | 0.6082 | -0.3793 | 0.4250 | |
| HCC1428 | HR+ | Luminal | Erlotinib | EGFR | ErbB | 0.000171 | uM | 7441.09 | 1.0090 | 1.0246 | 0.7331 | |
| HCC1428 | HR+ | Luminal | Erlotinib | EGFR | ErbB | 0.000853 | uM | 7441.09 | 1.0170 | 1.0466 | 0.7331 | |
| HCC1428 | HR+ | Luminal | Erlotinib | EGFR | ErbB | 0.00427 | uM | 7441.09 | 0.9950 | 0.9863 | 0.7331 |