Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 11939.155 | 0.9451 | 0.9333 | 1.6625 | |
| ZR75B | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 11939.155 | 0.9381 | 0.9246 | 1.6625 | |
| ZR75B | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 11939.155 | 0.9797 | 0.9755 | 1.6625 | |
| ZR75B | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 11939.155 | 0.8699 | 0.8392 | 1.6625 | |
| ZR75B | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 11939.155 | 0.4989 | 0.3164 | 1.6625 | |
| ZR75B | HR+ | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 11939.155 | 0.2243 | -0.1861 | 1.6625 | |
| ZR75B | HR+ | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 11939.155 | 0.4608 | 0.2549 | 1.6625 | |
| ZR75B | HR+ | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 11939.155 | 0.6840 | 0.5916 | 1.6625 | |
| 184A1 | NM | Basal | Dichloroacetate | PDK | PDK | 0.00000853 | uM | 12684.176 | 0.9141 | 0.8726 | 1.3650 | |
| 184A1 | NM | Basal | Dichloroacetate | PDK | PDK | 0.0000427 | uM | 12684.176 | 1.0138 | 1.0202 | 1.3650 | |
| 184A1 | NM | Basal | Dichloroacetate | PDK | PDK | 0.000213 | uM | 12684.176 | 0.9827 | 0.9747 | 1.3650 | |
| 184A1 | NM | Basal | Dichloroacetate | PDK | PDK | 0.00107 | uM | 12684.176 | 0.9948 | 0.9924 | 1.3650 | |
| 184A1 | NM | Basal | Dichloroacetate | PDK | PDK | 0.00533 | uM | 12684.176 | 1.0269 | 1.0392 | 1.3650 | |
| 184A1 | NM | Basal | Dichloroacetate | PDK | PDK | 0.0267 | uM | 12684.176 | 0.8629 | 0.7952 | 1.3650 | |
| 184A1 | NM | Basal | Dichloroacetate | PDK | PDK | 0.133 | uM | 12684.176 | 0.9811 | 0.9723 | 1.3650 | |
| 184A1 | NM | Basal | Dichloroacetate | PDK | PDK | 0.667 | uM | 12684.176 | 0.9680 | 0.9529 | 1.3650 | |
| 184A1 | NM | Basal | Dichloroacetate | PDK | PDK | 3.33 | uM | 12684.176 | 0.9423 | 0.9148 | 1.3650 | |
| 184B5 | NM | Basal | Dichloroacetate | PDK | PDK | 0.00000853 | uM | 12979.176 | 1.0643 | 1.1275 | 1.0091 | |
| 184B5 | NM | Basal | Dichloroacetate | PDK | PDK | 0.0000427 | uM | 12979.176 | 1.1032 | 1.2044 | 1.0091 | |
| 184B5 | NM | Basal | Dichloroacetate | PDK | PDK | 0.000213 | uM | 12979.176 | 1.1112 | 1.2203 | 1.0091 | |
| 184B5 | NM | Basal | Dichloroacetate | PDK | PDK | 0.00107 | uM | 12979.176 | 1.1180 | 1.2338 | 1.0091 | |
| 184B5 | NM | Basal | Dichloroacetate | PDK | PDK | 0.00533 | uM | 12979.176 | 1.2758 | 1.5460 | 1.0091 | |
| 184B5 | NM | Basal | Dichloroacetate | PDK | PDK | 0.0267 | uM | 12979.176 | 0.9118 | 0.8251 | 1.0091 | |
| 184B5 | NM | Basal | Dichloroacetate | PDK | PDK | 0.133 | uM | 12979.176 | 0.8962 | 0.7942 | 1.0091 | |
| 184B5 | NM | Basal | Dichloroacetate | PDK | PDK | 0.667 | uM | 12979.176 | 0.9539 | 0.9086 | 1.0091 |