Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 17.1 | uM | 9664.121 | 0.6657 | 0.1448 | 0.7294 | |
| MDA-MB-415 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 9664.121 | 0.1786 | -0.8115 | 0.7294 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.000218 | uM | 7899.077 | 0.9405 | 0.9448 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.00109 | uM | 7899.077 | 1.1093 | 1.0969 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.00546 | uM | 7899.077 | 0.9138 | 0.9195 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.0273 | uM | 7899.077 | 1.0846 | 1.0754 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.136 | uM | 7899.077 | 1.0539 | 1.0484 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.682 | uM | 7899.077 | 1.0571 | 1.0513 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 3.41 | uM | 7899.077 | 0.8062 | 0.8128 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 17.1 | uM | 7899.077 | 0.5872 | 0.5689 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 85.2 | uM | 7899.077 | 0.3017 | 0.1579 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.000218 | uM | 10266.121 | 1.0586 | 1.1668 | 0.7110 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.00109 | uM | 10266.121 | 1.2647 | 1.7828 | 0.7110 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.00546 | uM | 10266.121 | 1.0256 | 1.0724 | 0.7110 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.0273 | uM | 10266.121 | 1.0333 | 1.0943 | 0.7110 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.136 | uM | 10266.121 | 1.0499 | 1.1419 | 0.7110 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.682 | uM | 10266.121 | 1.0640 | 1.1823 | 0.7110 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 3.41 | uM | 10266.121 | 0.8522 | 0.5972 | 0.7110 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 17.1 | uM | 10266.121 | 0.6597 | 0.1143 | 0.7110 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 85.2 | uM | 10266.121 | 0.3665 | -0.5125 | 0.7110 | |
| MDA-MB-453 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.000218 | uM | 9708.121 | 0.9776 | 0.9606 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.00109 | uM | 9708.121 | 1.0817 | 1.1427 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.00546 | uM | 9708.121 | 0.9687 | 0.9450 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.0273 | uM | 9708.121 | 1.0463 | 1.0810 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.136 | uM | 9708.121 | 1.0828 | 1.1445 | 1.1394 |