Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.0273 | uM | 10061.121 | 0.9664 | 0.9650 | 1.9364 | |
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.136 | uM | 10061.121 | 0.9560 | 0.9541 | 1.9364 | |
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.682 | uM | 10061.121 | 0.7117 | 0.6779 | 1.9364 | |
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 3.41 | uM | 10061.121 | 0.4698 | 0.3540 | 1.9364 | |
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 17.1 | uM | 10061.121 | 0.3848 | 0.2213 | 1.9364 | |
| MCF12A | NM | Basal B | CPT-11 | TOP1 | TOP | 85.2 | uM | 10061.121 | 0.1618 | -0.2192 | 1.9364 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7875.007 | 1.0132 | 1.0176 | 1.4906 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7875.007 | 0.9898 | 0.9863 | 1.4906 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7875.007 | 1.0645 | 1.0857 | 1.4906 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7875.007 | 1.0582 | 1.0774 | 1.4906 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.118 | uM | 7875.007 | 1.0329 | 1.0440 | 1.4906 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.59 | uM | 7875.007 | 1.0199 | 1.0266 | 1.4906 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 2.95 | uM | 7875.007 | 0.9094 | 0.8766 | 1.4906 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 14.8 | uM | 7875.007 | 0.7721 | 0.6814 | 1.4906 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 73.8 | uM | 7875.007 | 0.1061 | -0.5559 | 1.4906 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000218 | uM | 9583.121 | 1.0672 | 1.1261 | 1.0648 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00109 | uM | 9583.121 | 1.0905 | 1.1695 | 1.0648 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00546 | uM | 9583.121 | 1.0749 | 1.1404 | 1.0648 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.0273 | uM | 9583.121 | 0.9806 | 0.9636 | 1.0648 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.136 | uM | 9583.121 | 0.9648 | 0.9338 | 1.0648 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.682 | uM | 9583.121 | 1.0076 | 1.0143 | 1.0648 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 3.41 | uM | 9583.121 | 0.9310 | 0.8702 | 1.0648 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 17.1 | uM | 9583.121 | 0.8337 | 0.6860 | 1.0648 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 9583.121 | 0.2259 | -0.5055 | 1.0648 | |
| MCF7 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000189 | uM | 10073.034 | 1.0028 | 1.0102 | 0.5531 |