Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Chk2 inhibitor II | CHK2 | CHK | 13.3 | uM | 10580.14 | 0.9342 | 0.8491 | 0.8679 | |
| UACC-812 | HER2amp | Luminal | Chk2 inhibitor II | CHK2 | CHK | 66.7 | uM | 10580.14 | 0.9329 | 0.8462 | 0.8679 | |
| 184B5 | NM | Basal | Chloroquine | 0.00017 | uM | 12979.177 | 2.1512 | 6.7648 | 0.5647 | |||
| 184B5 | NM | Basal | Chloroquine | 0.000851 | uM | 12979.177 | 1.5788 | 3.4899 | 0.5647 | |||
| 184B5 | NM | Basal | Chloroquine | 0.00426 | uM | 12979.177 | 1.1164 | 1.4306 | 0.5647 | |||
| 184B5 | NM | Basal | Chloroquine | 0.0213 | uM | 12979.177 | 0.8825 | 0.6028 | 0.5647 | |||
| 184B5 | NM | Basal | Chloroquine | 0.106 | uM | 12979.177 | 1.6012 | 3.6033 | 0.5647 | |||
| 184B5 | NM | Basal | Chloroquine | 0.532 | uM | 12979.177 | 1.3004 | 2.1845 | 0.5647 | |||
| 184B5 | NM | Basal | Chloroquine | 2.66 | uM | 12979.177 | 1.0640 | 1.2321 | 0.5647 | |||
| 184B5 | NM | Basal | Chloroquine | 13.3 | uM | 12979.177 | 0.9748 | 0.9116 | 0.5647 | |||
| 184B5 | NM | Basal | Chloroquine | 66.5 | uM | 12979.177 | 0.0006 | -1.0000 | 0.5647 | |||
| 600MPE | HR+ | Luminal | Chloroquine | 0.00017 | uM | 13091.177 | 1.0323 | 1.0928 | 0.7004 | |||
| 600MPE | HR+ | Luminal | Chloroquine | 0.000851 | uM | 13091.177 | 1.0352 | 1.1014 | 0.7004 | |||
| 600MPE | HR+ | Luminal | Chloroquine | 0.00426 | uM | 13091.177 | 0.9864 | 0.9613 | 0.7004 | |||
| 600MPE | HR+ | Luminal | Chloroquine | 0.0213 | uM | 13091.177 | 0.9957 | 0.9878 | 0.7004 | |||
| 600MPE | HR+ | Luminal | Chloroquine | 0.106 | uM | 13091.177 | 0.9866 | 0.9617 | 0.7004 | |||
| 600MPE | HR+ | Luminal | Chloroquine | 0.532 | uM | 13091.177 | 0.6243 | 0.0207 | 0.7004 | |||
| 600MPE | HR+ | Luminal | Chloroquine | 2.66 | uM | 13091.177 | 0.9569 | 0.8781 | 0.7004 | |||
| 600MPE | HR+ | Luminal | Chloroquine | 13.3 | uM | 13091.177 | 0.6871 | 0.1705 | 0.7004 | |||
| 600MPE | HR+ | Luminal | Chloroquine | 66.5 | uM | 13091.177 | 0.0005 | -1.0000 | 0.7004 | |||
| BT-474 | HER2amp | Luminal | Chloroquine | 0.00017 | uM | 13125.177 | 1.0159 | 1.0354 | 0.8991 | |||
| BT-474 | HER2amp | Luminal | Chloroquine | 0.000851 | uM | 13125.177 | 0.9849 | 0.9663 | 0.8991 | |||
| BT-474 | HER2amp | Luminal | Chloroquine | 0.00426 | uM | 13125.177 | 1.0491 | 1.1096 | 0.8991 | |||
| BT-474 | HER2amp | Luminal | Chloroquine | 0.0213 | uM | 13125.177 | 1.0294 | 1.0656 | 0.8991 | |||
| BT-474 | HER2amp | Luminal | Chloroquine | 0.106 | uM | 13125.177 | 0.7600 | 0.4739 | 0.8991 |