Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.32 | uM | 10095.034 | 1.0480 | 1.1227 | 0.7874 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 10095.034 | 0.7662 | 0.4260 | 0.7874 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 8 | uM | 10095.034 | 0.8234 | 0.5626 | 0.7874 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 40 | uM | 10095.034 | 0.7215 | 0.3214 | 0.7874 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 200 | uM | 10095.034 | 0.8569 | 0.6438 | 0.7874 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 1000 | uM | 10095.034 | 0.7857 | 0.4723 | 0.7874 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 10095.034 | 0.2627 | -0.6337 | 0.7874 | ||
| MDA-MB-415 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7897.018 | 0.9508 | 0.8840 | 0.8448 | ||
| MDA-MB-415 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.064 | uM | 7897.018 | 0.9675 | 0.9233 | 0.8448 | ||
| MDA-MB-415 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.32 | uM | 7897.018 | 0.8790 | 0.7168 | 0.8448 | ||
| MDA-MB-415 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 7897.018 | 0.8180 | 0.5768 | 0.8448 | ||
| MDA-MB-415 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 8 | uM | 7897.018 | 0.8329 | 0.6108 | 0.8448 | ||
| MDA-MB-415 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 40 | uM | 7897.018 | 0.8507 | 0.6516 | 0.8448 | ||
| MDA-MB-415 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 200 | uM | 7897.018 | 0.7375 | 0.3947 | 0.8448 | ||
| MDA-MB-415 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1000 | uM | 7897.018 | 0.4535 | -0.2157 | 0.8448 | ||
| MDA-MB-415 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 7897.018 | 0.0981 | -0.8720 | 0.8448 | ||
| MDA-MB-415 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.00128 | uM | 9664.124 | 1.0031 | 1.0073 | 0.8433 | ||
| MDA-MB-415 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.0064 | uM | 9664.124 | 0.9355 | 0.8481 | 0.8433 | ||
| MDA-MB-415 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.032 | uM | 9664.124 | 0.9655 | 0.9184 | 0.8433 | ||
| MDA-MB-415 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.16 | uM | 9664.124 | 0.8129 | 0.5644 | 0.8433 | ||
| MDA-MB-415 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.8 | uM | 9664.124 | 0.8493 | 0.6479 | 0.8433 | ||
| MDA-MB-415 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 4 | uM | 9664.124 | 0.8578 | 0.6674 | 0.8433 | ||
| MDA-MB-415 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 20 | uM | 9664.124 | 0.8469 | 0.6424 | 0.8433 | ||
| MDA-MB-415 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 100 | uM | 9664.124 | 0.5968 | 0.0844 | 0.8433 | ||
| MDA-MB-415 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 500 | uM | 9664.124 | 0.0431 | -0.9519 | 0.8433 |