Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184B5 | NM | Basal | Vorinostat | HDAC | HDAC | 30 | uM | 5897.065 | 0.9203 | 0.8762 | 1.2996 | |
| 184B5 | NM | Basal | Vorinostat | HDAC | HDAC | 150 | uM | 5897.065 | 0.7013 | 0.5221 | 1.2996 | |
| 184B5 | NM | Basal | Vorinostat | HDAC | HDAC | 750 | uM | 5897.065 | 0.5446 | 0.2530 | 1.2996 | |
| 184B5 | NM | Basal | Vorinostat | HDAC | HDAC | 3750 | uM | 5897.065 | 0.2748 | -0.2598 | 1.2996 | |
| 184B5 | NM | Basal | Vorinostat | HDAC | HDAC | 18700 | uM | 5897.065 | 0.0821 | -0.7078 | 1.2996 | |
| 600MPE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 5898.065 | 0.9380 | 0.8214 | 0.6845 | |
| 600MPE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 5898.065 | 0.9568 | 0.8749 | 0.6845 | |
| 600MPE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 5898.065 | 0.9469 | 0.8469 | 0.6845 | |
| 600MPE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 5898.065 | 0.8992 | 0.7123 | 0.6845 | |
| 600MPE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 5898.065 | 0.9029 | 0.7227 | 0.6845 | |
| 600MPE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 5898.065 | 0.6324 | 0.0240 | 0.6845 | |
| 600MPE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 5898.065 | 0.3076 | -0.6427 | 0.6845 | |
| 600MPE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 5898.065 | 0.0762 | -0.9535 | 0.6845 | |
| 600MPE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 5898.065 | 0.0322 | -0.9868 | 0.6845 | |
| 600MPE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 5899.065 | 0.8881 | 0.7945 | 1.0946 | |
| 600MPE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 5899.065 | 0.8911 | 0.8001 | 1.0946 | |
| 600MPE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 5899.065 | 0.9476 | 0.9039 | 1.0946 | |
| 600MPE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 5899.065 | 0.9013 | 0.8188 | 1.0946 | |
| 600MPE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 5899.065 | 0.8579 | 0.7387 | 1.0946 | |
| 600MPE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 5899.065 | 0.6445 | 0.3388 | 1.0946 | |
| 600MPE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 5899.065 | 0.2022 | -0.5358 | 1.0946 | |
| 600MPE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 5899.065 | 0.0229 | -0.9365 | 1.0946 | |
| 600MPE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 5899.065 | 0.0142 | -0.9590 | 1.0946 | |
| AU565 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 5900.065 | 0.9637 | 0.9667 | 2.2026 | |
| AU565 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 5900.065 | 0.9888 | 0.9898 | 2.2026 |