Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7553.065 | 0.1447 | -0.6937 | 1.0305 | |
| ZR75B | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7555.065 | 1.0056 | 1.0064 | 1.7561 | |
| ZR75B | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7555.065 | 0.9490 | 0.9413 | 1.7561 | |
| ZR75B | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7555.065 | 0.9413 | 0.9322 | 1.7561 | |
| ZR75B | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7555.065 | 0.8679 | 0.8450 | 1.7561 | |
| ZR75B | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7555.065 | 0.5123 | 0.3666 | 1.7561 | |
| ZR75B | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7555.065 | 0.1391 | -0.3496 | 1.7561 | |
| ZR75B | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7555.065 | 0.0616 | -0.5910 | 1.7561 | |
| ZR75B | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7555.065 | 0.0566 | -0.6101 | 1.7561 | |
| ZR75B | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7555.065 | 0.0393 | -0.6834 | 1.7561 | |
| 184A1 | NM | Basal | Triciribine | AKT | AKT | 0.0000853 | uM | 5894.074 | 0.9471 | 0.9267 | 1.4541 | |
| 184A1 | NM | Basal | Triciribine | AKT | AKT | 0.000427 | uM | 5894.074 | 1.0785 | 1.1067 | 1.4541 | |
| 184A1 | NM | Basal | Triciribine | AKT | AKT | 0.00213 | uM | 5894.074 | 0.9965 | 0.9952 | 1.4541 | |
| 184A1 | NM | Basal | Triciribine | AKT | AKT | 0.0107 | uM | 5894.074 | 0.9636 | 0.9496 | 1.4541 | |
| 184A1 | NM | Basal | Triciribine | AKT | AKT | 0.0533 | uM | 5894.074 | 0.7904 | 0.7013 | 1.4541 | |
| 184A1 | NM | Basal | Triciribine | AKT | AKT | 0.267 | uM | 5894.074 | 0.4178 | 0.0974 | 1.4541 | |
| 184A1 | NM | Basal | Triciribine | AKT | AKT | 1.33 | uM | 5894.074 | 0.2816 | -0.1635 | 1.4541 | |
| 184A1 | NM | Basal | Triciribine | AKT | AKT | 6.67 | uM | 5894.074 | 0.1701 | -0.4086 | 1.4541 | |
| 184A1 | NM | Basal | Triciribine | AKT | AKT | 33.3 | uM | 5894.074 | 0.0753 | -0.6622 | 1.4541 | |
| 184A1 | NM | Basal | Triciribine | AKT | AKT | 0.0000853 | uM | 5895.074 | 1.0168 | 1.0299 | 1.1218 | |
| 184A1 | NM | Basal | Triciribine | AKT | AKT | 0.000427 | uM | 5895.074 | 0.9968 | 0.9944 | 1.1218 | |
| 184A1 | NM | Basal | Triciribine | AKT | AKT | 0.00213 | uM | 5895.074 | 1.0073 | 1.0130 | 1.1218 | |
| 184A1 | NM | Basal | Triciribine | AKT | AKT | 0.0107 | uM | 5895.074 | 0.9697 | 0.9458 | 1.1218 | |
| 184A1 | NM | Basal | Triciribine | AKT | AKT | 0.0533 | uM | 5895.074 | 0.8046 | 0.6476 | 1.1218 | |
| 184A1 | NM | Basal | Triciribine | AKT | AKT | 0.267 | uM | 5895.074 | 0.4894 | 0.0578 | 1.1218 |