Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 66.7 | uM | 10380.093 | 0.6297 | 0.4657 | 1.4880 | |
| MCF 10A | NM | Basal B | TPCA-1 | IKK | NFKB | 0.000171 | uM | 7485.093 | 0.9449 | 0.9686 | 3.5766 | |
| MCF 10A | NM | Basal B | TPCA-1 | IKK | NFKB | 0.000853 | uM | 7485.093 | 1.0334 | 1.0185 | 3.5766 | |
| MCF 10A | NM | Basal B | TPCA-1 | IKK | NFKB | 0.00427 | uM | 7485.093 | 0.9995 | 0.9997 | 3.5766 | |
| MCF 10A | NM | Basal B | TPCA-1 | IKK | NFKB | 0.0213 | uM | 7485.093 | 0.9786 | 0.9879 | 3.5766 | |
| MCF 10A | NM | Basal B | TPCA-1 | IKK | NFKB | 0.107 | uM | 7485.093 | 0.9700 | 0.9831 | 3.5766 | |
| MCF 10A | NM | Basal B | TPCA-1 | IKK | NFKB | 0.533 | uM | 7485.093 | 0.9906 | 0.9947 | 3.5766 | |
| MCF 10A | NM | Basal B | TPCA-1 | IKK | NFKB | 2.67 | uM | 7485.093 | 0.7001 | 0.8103 | 3.5766 | |
| MCF 10A | NM | Basal B | TPCA-1 | IKK | NFKB | 13.3 | uM | 7485.093 | 0.1899 | 0.2570 | 3.5766 | |
| MCF 10A | NM | Basal B | TPCA-1 | IKK | NFKB | 66.7 | uM | 7485.093 | 0.1171 | 0.0979 | 3.5766 | |
| MCF 10F | NM | - | TPCA-1 | IKK | NFKB | 0.000341 | uM | 7486.1 | 0.9983 | 0.9967 | 1.0281 | |
| MCF 10F | NM | - | TPCA-1 | IKK | NFKB | 0.00171 | uM | 7486.1 | 1.0805 | 1.1563 | 1.0281 | |
| MCF 10F | NM | - | TPCA-1 | IKK | NFKB | 0.00853 | uM | 7486.1 | 1.0086 | 1.0168 | 1.0281 | |
| MCF 10F | NM | - | TPCA-1 | IKK | NFKB | 0.0427 | uM | 7486.1 | 1.0169 | 1.0329 | 1.0281 | |
| MCF 10F | NM | - | TPCA-1 | IKK | NFKB | 0.213 | uM | 7486.1 | 1.0279 | 1.0543 | 1.0281 | |
| MCF 10F | NM | - | TPCA-1 | IKK | NFKB | 1.07 | uM | 7486.1 | 1.0949 | 1.1843 | 1.0281 | |
| MCF 10F | NM | - | TPCA-1 | IKK | NFKB | 5.33 | uM | 7486.1 | 0.7791 | 0.5689 | 1.0281 | |
| MCF 10F | NM | - | TPCA-1 | IKK | NFKB | 26.7 | uM | 7486.1 | 0.4280 | -0.1239 | 1.0281 | |
| MCF 10F | NM | - | TPCA-1 | IKK | NFKB | 133 | uM | 7486.1 | 0.3393 | -0.3011 | 1.0281 | |
| MCF12A | NM | Basal B | TPCA-1 | IKK | NFKB | 0.000171 | uM | 7490.093 | 0.9505 | 0.9576 | 2.3707 | |
| MCF12A | NM | Basal B | TPCA-1 | IKK | NFKB | 0.000853 | uM | 7490.093 | 1.0019 | 1.0016 | 2.3707 | |
| MCF12A | NM | Basal B | TPCA-1 | IKK | NFKB | 0.00427 | uM | 7490.093 | 0.9989 | 0.9991 | 2.3707 | |
| MCF12A | NM | Basal B | TPCA-1 | IKK | NFKB | 0.0213 | uM | 7490.093 | 0.9980 | 0.9983 | 2.3707 | |
| MCF12A | NM | Basal B | TPCA-1 | IKK | NFKB | 0.107 | uM | 7490.093 | 1.0251 | 1.0210 | 2.3707 | |
| MCF12A | NM | Basal B | TPCA-1 | IKK | NFKB | 0.533 | uM | 7490.093 | 0.9674 | 0.9722 | 2.3707 |