Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0533 | uM | 11660.153 | 0.9609 | 0.9051 | 0.8197 | |
| ZR-75-1 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.267 | uM | 11660.153 | 0.9308 | 0.8324 | 0.8197 | |
| ZR-75-1 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 1.33 | uM | 11660.153 | 0.9470 | 0.8715 | 0.8197 | |
| ZR-75-1 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 6.67 | uM | 11660.153 | 0.7650 | 0.4424 | 0.8197 | |
| ZR-75-1 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 33.3 | uM | 11660.153 | 0.5204 | -0.0985 | 0.8197 | |
| ZR-75-1 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 12003.165 | 0.9735 | 0.9484 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.000427 | uM | 12003.165 | 0.8921 | 0.7895 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.00213 | uM | 12003.165 | 0.9567 | 0.9155 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0107 | uM | 12003.165 | 0.9337 | 0.8708 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0533 | uM | 12003.165 | 1.0011 | 1.0022 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.267 | uM | 12003.165 | 0.9040 | 0.8127 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 1.33 | uM | 12003.165 | 0.9563 | 0.9148 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 6.67 | uM | 12003.165 | 0.7047 | 0.4223 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 33.3 | uM | 12003.165 | 0.5784 | 0.1734 | 1.0267 | |
| ZR75B | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.000171 | uM | 11939.158 | 0.9394 | 0.9289 | 1.7251 | |
| ZR75B | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.000853 | uM | 11939.158 | 0.8431 | 0.8116 | 1.7251 | |
| ZR75B | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.00427 | uM | 11939.158 | 0.9623 | 0.9559 | 1.7251 | |
| ZR75B | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0213 | uM | 11939.158 | 0.9507 | 0.9423 | 1.7251 | |
| ZR75B | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.107 | uM | 11939.158 | 0.8481 | 0.8178 | 1.7251 | |
| ZR75B | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.533 | uM | 11939.158 | 0.8236 | 0.7872 | 1.7251 | |
| ZR75B | HR+ | Luminal | AS-252424 | PI3K | PI3K | 2.67 | uM | 11939.158 | 0.7776 | 0.7286 | 1.7251 | |
| ZR75B | HR+ | Luminal | AS-252424 | PI3K | PI3K | 13.3 | uM | 11939.158 | 0.5812 | 0.4603 | 1.7251 | |
| ZR75B | HR+ | Luminal | AS-252424 | PI3K | PI3K | 66.7 | uM | 11939.158 | 0.6378 | 0.5411 | 1.7251 | |
| 184A1 | NM | Basal | Baicalein | Lipoxygenase | Metabolism | 0.000427 | uM | 5895.073 | 1.0365 | 1.0503 | 1.4431 | |
| 184A1 | NM | Basal | Baicalein | Lipoxygenase | Metabolism | 0.00213 | uM | 5895.073 | 1.0337 | 1.0465 | 1.4431 |