Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184B5 | NM | Basal | PD184352 | MEK | MAPK | 6.67 | uM | 12566.155 | 0.5813 | 0.4058 | 1.5389 | |
| 184B5 | NM | Basal | PD184352 | MEK | MAPK | 33.3 | uM | 12566.155 | 0.3053 | -0.0750 | 1.5389 | |
| 184B5 | NM | Basal | PD184352 | MEK | MAPK | 33.3 | uM | 12566.155 | 0.3053 | -0.0750 | 1.5389 | |
| 600MPE | HR+ | Luminal | PD184352 | MEK | MAPK | 0.0000853 | uM | 12224.155 | 0.8809 | 0.7700 | 1.0378 | |
| 600MPE | HR+ | Luminal | PD184352 | MEK | MAPK | 0.0000853 | uM | 12224.155 | 0.8809 | 0.7700 | 1.0378 | |
| 600MPE | HR+ | Luminal | PD184352 | MEK | MAPK | 0.000427 | uM | 12224.155 | 0.9041 | 0.8149 | 1.0378 | |
| 600MPE | HR+ | Luminal | PD184352 | MEK | MAPK | 0.000427 | uM | 12224.155 | 0.9041 | 0.8149 | 1.0378 | |
| 600MPE | HR+ | Luminal | PD184352 | MEK | MAPK | 0.00213 | uM | 12224.155 | 0.9807 | 0.9628 | 1.0378 | |
| 600MPE | HR+ | Luminal | PD184352 | MEK | MAPK | 0.00213 | uM | 12224.155 | 0.9807 | 0.9628 | 1.0378 | |
| 600MPE | HR+ | Luminal | PD184352 | MEK | MAPK | 0.0107 | uM | 12224.155 | 0.8965 | 0.8002 | 1.0378 | |
| 600MPE | HR+ | Luminal | PD184352 | MEK | MAPK | 0.0107 | uM | 12224.155 | 0.8965 | 0.8002 | 1.0378 | |
| 600MPE | HR+ | Luminal | PD184352 | MEK | MAPK | 0.0533 | uM | 12224.155 | 0.8967 | 0.8006 | 1.0378 | |
| 600MPE | HR+ | Luminal | PD184352 | MEK | MAPK | 0.0533 | uM | 12224.155 | 0.8967 | 0.8006 | 1.0378 | |
| 600MPE | HR+ | Luminal | PD184352 | MEK | MAPK | 0.267 | uM | 12224.155 | 0.8659 | 0.7410 | 1.0378 | |
| 600MPE | HR+ | Luminal | PD184352 | MEK | MAPK | 0.267 | uM | 12224.155 | 0.8659 | 0.7410 | 1.0378 | |
| 600MPE | HR+ | Luminal | PD184352 | MEK | MAPK | 1.33 | uM | 12224.155 | 0.9122 | 0.8306 | 1.0378 | |
| 600MPE | HR+ | Luminal | PD184352 | MEK | MAPK | 1.33 | uM | 12224.155 | 0.9122 | 0.8306 | 1.0378 | |
| 600MPE | HR+ | Luminal | PD184352 | MEK | MAPK | 6.67 | uM | 12224.155 | 0.9063 | 0.8190 | 1.0378 | |
| 600MPE | HR+ | Luminal | PD184352 | MEK | MAPK | 6.67 | uM | 12224.155 | 0.9063 | 0.8190 | 1.0378 | |
| 600MPE | HR+ | Luminal | PD184352 | MEK | MAPK | 33.3 | uM | 12224.155 | 0.8386 | 0.6879 | 1.0378 | |
| 600MPE | HR+ | Luminal | PD184352 | MEK | MAPK | 33.3 | uM | 12224.155 | 0.8386 | 0.6879 | 1.0378 | |
| AU565 | HER2amp | Luminal | PD184352 | MEK | MAPK | 0.0000853 | uM | 10880.155 | 0.9178 | 0.8903 | 1.5205 | |
| AU565 | HER2amp | Luminal | PD184352 | MEK | MAPK | 0.0000853 | uM | 10880.155 | 0.9178 | 0.8903 | 1.5205 | |
| AU565 | HER2amp | Luminal | PD184352 | MEK | MAPK | 0.000427 | uM | 10880.155 | 0.9755 | 0.9676 | 1.5205 | |
| AU565 | HER2amp | Luminal | PD184352 | MEK | MAPK | 0.000427 | uM | 10880.155 | 0.9755 | 0.9676 | 1.5205 |