Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 1.01 | uM | 10061.12 | 0.5218 | 0.4600 | 2.0669 | |
| MCF12A | NM | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 5.03 | uM | 10061.12 | 0.5240 | 0.4629 | 2.0669 | |
| MCF12A | NM | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 25.2 | uM | 10061.12 | 0.4648 | 0.3805 | 2.0669 | |
| MCF12A | NM | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 126 | uM | 10061.12 | 0.0215 | -0.6879 | 2.0669 | |
| MCF12A | NM | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 629 | uM | 10061.12 | 0.0120 | -0.7649 | 2.0669 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.00161 | uM | 7875.011 | 0.9844 | 0.9815 | 1.6960 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.00805 | uM | 7875.011 | 0.9368 | 0.9245 | 1.6960 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.0403 | uM | 7875.011 | 0.9968 | 0.9963 | 1.6960 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.201 | uM | 7875.011 | 0.9284 | 0.9143 | 1.6960 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 1.01 | uM | 7875.011 | 0.6670 | 0.5752 | 1.6960 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 5.03 | uM | 7875.011 | 0.5862 | 0.4596 | 1.6960 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 25.2 | uM | 7875.011 | 0.4782 | 0.2945 | 1.6960 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 126 | uM | 7875.011 | 0.1322 | -0.3934 | 1.6960 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 629 | uM | 7875.011 | 0.0433 | -0.6858 | 1.6960 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.00161 | uM | 9583.011 | 1.0706 | 1.1353 | 1.0421 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.00805 | uM | 9583.011 | 1.0006 | 1.0011 | 1.0421 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.0403 | uM | 9583.011 | 1.0441 | 1.0845 | 1.0421 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.201 | uM | 9583.011 | 1.0314 | 1.0603 | 1.0421 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 1.01 | uM | 9583.011 | 0.7905 | 0.5960 | 1.0421 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 5.03 | uM | 9583.011 | 0.7642 | 0.5452 | 1.0421 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 25.2 | uM | 9583.011 | 0.6686 | 0.3592 | 1.0421 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 126 | uM | 9583.011 | 0.3332 | -0.3034 | 1.0421 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 629 | uM | 9583.011 | 0.1249 | -0.7284 | 1.0421 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.00161 | uM | 10073.021 | 1.0227 | 1.0808 | 0.5665 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.00805 | uM | 10073.021 | 1.0270 | 1.0964 | 0.5665 |