Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7512.084 | 0.0135 | -0.9935 | 0.7511 | |
| MDA-MB-415 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7512.084 | 0.0089 | -0.9963 | 0.7511 | |
| MDA-MB-415 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7512.084 | 0.0007 | -0.9999 | 0.7511 | |
| MDA-MB-453 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7517.084 | 0.9652 | 0.9503 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7517.084 | 0.9458 | 0.9224 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7517.084 | 0.9619 | 0.9456 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7517.084 | 0.8995 | 0.8551 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7517.084 | 0.7807 | 0.6775 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7517.084 | 0.3263 | -0.0973 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7517.084 | 0.0052 | -0.9520 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7517.084 | 0.0087 | -0.9313 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7517.084 | 0.0030 | -0.9680 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7518.084 | 0.9652 | 0.9472 | 1.3244 | |
| MDA-MB-453 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7518.084 | 1.1411 | 1.2096 | 1.3244 | |
| MDA-MB-453 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7518.084 | 0.9916 | 0.9873 | 1.3244 | |
| MDA-MB-453 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7518.084 | 0.9730 | 0.9592 | 1.3244 | |
| MDA-MB-453 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7518.084 | 0.7833 | 0.6632 | 1.3244 | |
| MDA-MB-453 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7518.084 | 0.4329 | 0.0629 | 1.3244 | |
| MDA-MB-453 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7518.084 | 0.0111 | -0.9331 | 1.3244 | |
| MDA-MB-453 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7518.084 | 0.0110 | -0.9335 | 1.3244 | |
| MDA-MB-453 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7518.084 | 0.0106 | -0.9355 | 1.3244 | |
| MX1 | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7523.084 | 0.9581 | 0.9078 | 0.9069 | |
| MX1 | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7523.084 | 0.9341 | 0.8551 | 0.9069 | |
| MX1 | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7523.084 | 0.9470 | 0.8835 | 0.9069 | |
| MX1 | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7523.084 | 0.9555 | 0.9021 | 0.9069 |