Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7499.084 | 0.9168 | 0.7940 | 0.7991 | |
| MDA-MB-175-VII | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7499.084 | 0.8545 | 0.6428 | 0.7991 | |
| MDA-MB-175-VII | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7499.084 | 0.7102 | 0.3034 | 0.7991 | |
| MDA-MB-175-VII | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7499.084 | 0.0023 | -0.9990 | 0.7991 | |
| MDA-MB-175-VII | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7499.084 | 0.0017 | -0.9993 | 0.7991 | |
| MDA-MB-175-VII | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7499.084 | 0.0003 | -0.9999 | 0.7991 | |
| MDA-MB-175-VII | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7500.084 | 0.9356 | 0.7836 | 0.5811 | |
| MDA-MB-175-VII | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7500.084 | 0.9370 | 0.7882 | 0.5811 | |
| MDA-MB-175-VII | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7500.084 | 0.9968 | 0.9891 | 0.5811 | |
| MDA-MB-175-VII | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7500.084 | 1.0855 | 1.3031 | 0.5811 | |
| MDA-MB-175-VII | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7500.084 | 1.0064 | 1.0222 | 0.5811 | |
| MDA-MB-175-VII | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7500.084 | 0.6681 | -0.0008 | 0.5811 | |
| MDA-MB-175-VII | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7500.084 | 0.0270 | -0.9960 | 0.5811 | |
| MDA-MB-175-VII | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7500.084 | 0.0196 | -0.9977 | 0.5811 | |
| MDA-MB-175-VII | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7500.084 | 0.0035 | -0.9999 | 0.5811 | |
| MDA-MB-231 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7504.084 | 1.0077 | 1.0082 | 1.8866 | |
| MDA-MB-231 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7504.084 | 1.1401 | 1.1439 | 1.8866 | |
| MDA-MB-231 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7504.084 | 1.2124 | 1.2150 | 1.8866 | |
| MDA-MB-231 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7504.084 | 1.1778 | 1.1812 | 1.8866 | |
| MDA-MB-231 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7504.084 | 0.9226 | 0.9163 | 1.8866 | |
| MDA-MB-231 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7504.084 | 0.5195 | 0.4135 | 1.8866 | |
| MDA-MB-231 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7504.084 | 0.0247 | -0.7187 | 1.8866 | |
| MDA-MB-231 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7504.084 | 0.0134 | -0.7964 | 1.8866 | |
| MDA-MB-231 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7504.084 | 0.0003 | -0.9722 | 1.8866 | |
| MDA-MB-361 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7506.085 | 1.0724 | 1.1314 | 1.0985 |