Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
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AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.0276 | uM | 7793.007 | 0.9547 | 0.9341 | 1.3832 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.138 | uM | 7793.007 | 0.5470 | 0.2930 | 1.3832 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.69 | uM | 7793.007 | 0.1182 | -0.5728 | 1.3832 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 3.45 | uM | 7793.007 | 0.0125 | -0.9157 | 1.3832 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 17.2 | uM | 7793.007 | 0.0095 | -0.9308 | 1.3832 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7793.007 | 0.0056 | -0.9529 | 1.3832 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 9035.077 | 0.9781 | 0.9816 | 2.3909 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.00118 | uM | 9035.077 | 1.0182 | 1.0152 | 2.3909 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 9035.077 | 1.0335 | 1.0277 | 2.3909 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 9035.077 | 0.9811 | 0.9841 | 2.3909 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.147 | uM | 9035.077 | 0.3275 | 0.2540 | 2.3909 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.736 | uM | 9035.077 | 0.0912 | -0.2653 | 2.3909 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 3.68 | uM | 9035.077 | 0.0063 | -0.7602 | 2.3909 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 18.4 | uM | 9035.077 | 0.0021 | -0.8469 | 2.3909 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 92 | uM | 9035.077 | 0.0007 | -0.9043 | 2.3909 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 9146.121 | 1.0280 | 1.0492 | 1.1366 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.00118 | uM | 9146.121 | 0.9685 | 0.9444 | 1.1366 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 9146.121 | 0.8009 | 0.6452 | 1.1366 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 9146.121 | 0.9607 | 0.9306 | 1.1366 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.147 | uM | 9146.121 | 0.6065 | 0.2882 | 1.1366 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.736 | uM | 9146.121 | 0.1244 | -0.6804 | 1.1366 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 3.68 | uM | 9146.121 | 0.0131 | -0.9559 | 1.1366 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 18.4 | uM | 9146.121 | 0.0076 | -0.9726 | 1.1366 | |
AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 92 | uM | 9146.121 | 0.0026 | -0.9894 | 1.1366 | |
BT-474 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 7798.077 | 1.0126 | 1.0175 | 1.4371 |