Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184A1 | NM | Basal | Doxorubicin | TOP2 | TOP | 0.69 | uM | 10002.034 | 0.2280 | -0.7773 | 0.6736 | |
| 184A1 | NM | Basal | Doxorubicin | TOP2 | TOP | 3.45 | uM | 10002.034 | 0.1658 | -0.8612 | 0.6736 | |
| 184A1 | NM | Basal | Doxorubicin | TOP2 | TOP | 17.2 | uM | 10002.034 | 0.0417 | -0.9821 | 0.6736 | |
| 184A1 | NM | Basal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 10002.034 | 0.0003 | -1.0000 | 0.6736 | |
| 184B5 | NM | Basal | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 9095.121 | 1.0184 | 1.0306 | 1.1992 | |
| 184B5 | NM | Basal | Doxorubicin | TOP2 | TOP | 0.00118 | uM | 9095.121 | 0.9705 | 0.9507 | 1.1992 | |
| 184B5 | NM | Basal | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 9095.121 | 0.9423 | 0.9032 | 1.1992 | |
| 184B5 | NM | Basal | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 9095.121 | 0.8238 | 0.7015 | 1.1992 | |
| 184B5 | NM | Basal | Doxorubicin | TOP2 | TOP | 0.147 | uM | 9095.121 | 0.6627 | 0.4192 | 1.1992 | |
| 184B5 | NM | Basal | Doxorubicin | TOP2 | TOP | 0.736 | uM | 9095.121 | 0.0508 | -0.8333 | 1.1992 | |
| 184B5 | NM | Basal | Doxorubicin | TOP2 | TOP | 3.68 | uM | 9095.121 | 0.0119 | -0.9502 | 1.1992 | |
| 184B5 | NM | Basal | Doxorubicin | TOP2 | TOP | 18.4 | uM | 9095.121 | 0.0078 | -0.9651 | 1.1992 | |
| 184B5 | NM | Basal | Doxorubicin | TOP2 | TOP | 92 | uM | 9095.121 | 0.0020 | -0.9889 | 1.1992 | |
| 600MPE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.000221 | uM | 9120.034 | 1.0901 | 1.3103 | 0.5982 | |
| 600MPE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.0011 | uM | 9120.034 | 0.9726 | 0.9091 | 0.5982 | |
| 600MPE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.00552 | uM | 9120.034 | 1.0599 | 1.2041 | 0.5982 | |
| 600MPE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.0276 | uM | 9120.034 | 0.9981 | 0.9937 | 0.5982 | |
| 600MPE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.138 | uM | 9120.034 | 1.0195 | 1.0657 | 0.5982 | |
| 600MPE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.69 | uM | 9120.034 | 0.7526 | 0.2436 | 0.5982 | |
| 600MPE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 3.45 | uM | 9120.034 | 0.3560 | -0.6442 | 0.5982 | |
| 600MPE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 17.2 | uM | 9120.034 | 0.4339 | -0.5048 | 0.5982 | |
| 600MPE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 9120.034 | 0.0158 | -0.9981 | 0.5982 | |
| AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.000221 | uM | 7793.007 | 1.0271 | 1.0390 | 1.3832 | |
| AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.0011 | uM | 7793.007 | 0.9693 | 0.9554 | 1.3832 | |
| AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.00552 | uM | 7793.007 | 0.8180 | 0.7296 | 1.3832 |