Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 11938.155 | 0.9189 | 0.7694 | 0.6903 | |
| UACC-812 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 11938.155 | 0.9133 | 0.7539 | 0.6903 | |
| UACC-812 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 11938.155 | 0.5942 | -0.0590 | 0.6903 | |
| UACC-812 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 11938.155 | 0.2762 | -0.6899 | 0.6903 | |
| UACC-812 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 11938.155 | 0.5337 | -0.1947 | 0.6903 | |
| UACC-812 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 11938.155 | 0.8263 | 0.5169 | 0.6903 | |
| ZR-75-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 11660.146 | 0.9066 | 0.8074 | 0.9684 | |
| ZR-75-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 11660.146 | 0.8940 | 0.7814 | 0.9684 | |
| ZR-75-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 11660.146 | 0.9173 | 0.8295 | 0.9684 | |
| ZR-75-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 11660.146 | 0.9206 | 0.8363 | 0.9684 | |
| ZR-75-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 11660.146 | 0.8951 | 0.7837 | 0.9684 | |
| ZR-75-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 11660.146 | 0.9058 | 0.8058 | 0.9684 | |
| ZR-75-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 11660.146 | 0.8978 | 0.7894 | 0.9684 | |
| ZR-75-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 11660.146 | 0.8910 | 0.7752 | 0.9684 | |
| ZR-75-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 11660.146 | 0.8737 | 0.7398 | 0.9684 | |
| ZR-75-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12003.155 | 0.9504 | 0.9115 | 1.1249 | |
| ZR-75-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12003.155 | 0.9063 | 0.8324 | 1.1249 | |
| ZR-75-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12003.155 | 0.9311 | 0.8770 | 1.1249 | |
| ZR-75-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12003.155 | 0.9053 | 0.8307 | 1.1249 | |
| ZR-75-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12003.155 | 0.8056 | 0.6504 | 1.1249 | |
| ZR-75-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 12003.155 | 0.6427 | 0.3500 | 1.1249 | |
| ZR-75-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 12003.155 | 0.5156 | 0.1099 | 1.1249 | |
| ZR-75-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 12003.155 | 0.8289 | 0.6928 | 1.1249 | |
| ZR-75-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 12003.155 | 0.6875 | 0.4333 | 1.1249 | |
| ZR75B | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 11939.155 | 0.9469 | 0.9355 | 1.6625 |