Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12254.155 | 1.0170 | 1.0186 | 1.8150 | |
| MCF 10F | NM | - | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12254.155 | 0.9748 | 0.9721 | 1.8150 | |
| MCF 10F | NM | - | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12254.155 | 1.0224 | 1.0245 | 1.8150 | |
| MCF 10F | NM | - | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12254.155 | 0.8605 | 0.8411 | 1.8150 | |
| MCF 10F | NM | - | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12254.155 | 0.7831 | 0.7479 | 1.8150 | |
| MCF 10F | NM | - | Dactolisib | PI3K | PI3K | 0.267 | uM | 12254.155 | 0.7051 | 0.6497 | 1.8150 | |
| MCF 10F | NM | - | Dactolisib | PI3K | PI3K | 1.33 | uM | 12254.155 | 0.2945 | 0.0198 | 1.8150 | |
| MCF 10F | NM | - | Dactolisib | PI3K | PI3K | 6.67 | uM | 12254.155 | 0.8354 | 0.8113 | 1.8150 | |
| MCF 10F | NM | - | Dactolisib | PI3K | PI3K | 33.3 | uM | 12254.155 | 0.7787 | 0.7426 | 1.8150 | |
| MCF12A | NM | Basal B | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10817.155 | 0.9389 | 0.9229 | 1.6045 | |
| MCF12A | NM | Basal B | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10817.155 | 0.9773 | 0.9716 | 1.6045 | |
| MCF12A | NM | Basal B | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10817.155 | 0.9312 | 0.9131 | 1.6045 | |
| MCF12A | NM | Basal B | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10817.155 | 0.9367 | 0.9202 | 1.6045 | |
| MCF12A | NM | Basal B | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10817.155 | 0.9379 | 0.9217 | 1.6045 | |
| MCF12A | NM | Basal B | Dactolisib | PI3K | PI3K | 0.267 | uM | 10817.155 | 0.9220 | 0.9012 | 1.6045 | |
| MCF12A | NM | Basal B | Dactolisib | PI3K | PI3K | 1.33 | uM | 10817.155 | 0.4582 | 0.2296 | 1.6045 | |
| MCF12A | NM | Basal B | Dactolisib | PI3K | PI3K | 6.67 | uM | 10817.155 | 0.4230 | 0.1699 | 1.6045 | |
| MCF12A | NM | Basal B | Dactolisib | PI3K | PI3K | 33.3 | uM | 10817.155 | 0.4668 | 0.2440 | 1.6045 | |
| MCF12A | NM | Basal B | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12365.155 | 0.9281 | 0.9306 | 2.1113 | |
| MCF12A | NM | Basal B | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12365.155 | 0.9417 | 0.9439 | 2.1113 | |
| MCF12A | NM | Basal B | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12365.155 | 0.9962 | 0.9964 | 2.1113 | |
| MCF12A | NM | Basal B | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12365.155 | 1.0030 | 1.0028 | 2.1113 | |
| MCF12A | NM | Basal B | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12365.155 | 0.9656 | 0.9671 | 2.1113 | |
| MCF12A | NM | Basal B | Dactolisib | PI3K | PI3K | 0.267 | uM | 12365.155 | 0.6736 | 0.6587 | 2.1113 | |
| MCF12A | NM | Basal B | Dactolisib | PI3K | PI3K | 1.33 | uM | 12365.155 | 0.2406 | 0.0185 | 2.1113 |