Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12400.155 | 0.9469 | 0.9149 | 1.2558 | |
| HCC70 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.267 | uM | 12400.155 | 0.4672 | 0.0910 | 1.2558 | |
| HCC70 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 1.33 | uM | 12400.155 | 0.3390 | -0.1548 | 1.2558 | |
| HCC70 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 6.67 | uM | 12400.155 | 0.3888 | -0.0575 | 1.2558 | |
| HCC70 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 33.3 | uM | 12400.155 | 0.4045 | -0.0272 | 1.2558 | |
| Hs 578T | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10694.146 | 1.0441 | 1.0382 | 2.2821 | |
| Hs 578T | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10694.146 | 0.9912 | 0.9923 | 2.2821 | |
| Hs 578T | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10694.146 | 1.0723 | 1.0622 | 2.2821 | |
| Hs 578T | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10694.146 | 1.0046 | 1.0040 | 2.2821 | |
| Hs 578T | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10694.146 | 1.0254 | 1.0221 | 2.2821 | |
| Hs 578T | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.267 | uM | 10694.146 | 1.0107 | 1.0094 | 2.2821 | |
| Hs 578T | TNBC | Basal B | Dactolisib | PI3K | PI3K | 1.33 | uM | 10694.146 | 0.9310 | 0.9383 | 2.2821 | |
| Hs 578T | TNBC | Basal B | Dactolisib | PI3K | PI3K | 6.67 | uM | 10694.146 | 0.9242 | 0.9321 | 2.2821 | |
| Hs 578T | TNBC | Basal B | Dactolisib | PI3K | PI3K | 33.3 | uM | 10694.146 | 0.9715 | 0.9749 | 2.2821 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10816.155 | 1.0550 | 1.1323 | 0.8353 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10816.155 | 1.0689 | 1.1660 | 0.8353 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10816.155 | 1.1049 | 1.2536 | 0.8353 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10816.155 | 0.9907 | 0.9778 | 0.8353 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10816.155 | 0.9397 | 0.8566 | 0.8353 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 10816.155 | 0.5946 | 0.0733 | 0.8353 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 10816.155 | 0.1968 | -0.7144 | 0.8353 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 10816.155 | 0.1356 | -0.8172 | 0.8353 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 10816.155 | 0.2035 | -0.7027 | 0.8353 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12319.155 | 0.8835 | 0.7514 | 0.9333 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12319.155 | 1.0668 | 1.1435 | 0.9333 |