Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 10880.155 | 0.2532 | -0.1896 | 1.5205 | |
| AU565 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 10880.155 | 0.6996 | 0.5813 | 1.5205 | |
| AU565 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 10880.155 | 0.6632 | 0.5266 | 1.5205 | |
| BT-20 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10581.146 | 0.9842 | 0.9728 | 1.1650 | |
| BT-20 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10581.146 | 0.9313 | 0.8814 | 1.1650 | |
| BT-20 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10581.146 | 0.9852 | 0.9745 | 1.1650 | |
| BT-20 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10581.146 | 0.9212 | 0.8640 | 1.1650 | |
| BT-20 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10581.146 | 0.9386 | 0.8940 | 1.1650 | |
| BT-20 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.267 | uM | 10581.146 | 0.9335 | 0.8853 | 1.1650 | |
| BT-20 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 1.33 | uM | 10581.146 | 0.8589 | 0.7552 | 1.1650 | |
| BT-20 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 6.67 | uM | 10581.146 | 0.5302 | 0.1601 | 1.1650 | |
| BT-20 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 33.3 | uM | 10581.146 | 0.7219 | 0.5119 | 1.1650 | |
| BT-20 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 11854.155 | 0.9646 | 0.9469 | 1.3396 | |
| BT-20 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.000427 | uM | 11854.155 | 0.9983 | 0.9975 | 1.3396 | |
| BT-20 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.00213 | uM | 11854.155 | 0.9397 | 0.9093 | 1.3396 | |
| BT-20 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0107 | uM | 11854.155 | 1.0244 | 1.0364 | 1.3396 | |
| BT-20 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0533 | uM | 11854.155 | 0.8485 | 0.7692 | 1.3396 | |
| BT-20 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.267 | uM | 11854.155 | 0.6556 | 0.4592 | 1.3396 | |
| BT-20 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 1.33 | uM | 11854.155 | 0.4887 | 0.1719 | 1.3396 | |
| BT-20 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 6.67 | uM | 11854.155 | 0.6606 | 0.4676 | 1.3396 | |
| BT-20 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 33.3 | uM | 11854.155 | 0.5141 | 0.2170 | 1.3396 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12056.155 | 0.9058 | 0.7740 | 0.8251 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12056.155 | 0.9078 | 0.7787 | 0.8251 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12056.155 | 0.9800 | 0.9517 | 0.8251 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12056.155 | 0.9040 | 0.7697 | 0.8251 |