Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184A1 | NM | Basal | Dactolisib | PI3K | PI3K | 33.3 | uM | 12509.155 | 0.4741 | 0.1480 | 1.3444 | |
| 184B5 | NM | Basal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12566.155 | 1.1319 | 1.1677 | 1.5389 | |
| 184B5 | NM | Basal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12566.155 | 0.9943 | 0.9926 | 1.5389 | |
| 184B5 | NM | Basal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12566.155 | 0.9705 | 0.9615 | 1.5389 | |
| 184B5 | NM | Basal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12566.155 | 0.9028 | 0.8714 | 1.5389 | |
| 184B5 | NM | Basal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12566.155 | 0.9672 | 0.9571 | 1.5389 | |
| 184B5 | NM | Basal | Dactolisib | PI3K | PI3K | 0.267 | uM | 12566.155 | 0.4132 | 0.1262 | 1.5389 | |
| 184B5 | NM | Basal | Dactolisib | PI3K | PI3K | 1.33 | uM | 12566.155 | 0.3697 | 0.0475 | 1.5389 | |
| 184B5 | NM | Basal | Dactolisib | PI3K | PI3K | 6.67 | uM | 12566.155 | 0.4026 | 0.1073 | 1.5389 | |
| 184B5 | NM | Basal | Dactolisib | PI3K | PI3K | 33.3 | uM | 12566.155 | 0.4767 | 0.2357 | 1.5389 | |
| 600MPE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12224.155 | 0.9939 | 0.9883 | 1.0378 | |
| 600MPE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12224.155 | 0.9497 | 0.9030 | 1.0378 | |
| 600MPE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12224.155 | 0.9376 | 0.8795 | 1.0378 | |
| 600MPE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12224.155 | 0.9721 | 0.9462 | 1.0378 | |
| 600MPE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12224.155 | 0.8891 | 0.7858 | 1.0378 | |
| 600MPE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 12224.155 | 1.0251 | 1.0483 | 1.0378 | |
| 600MPE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 12224.155 | 0.5759 | 0.1752 | 1.0378 | |
| 600MPE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 12224.155 | 0.8939 | 0.7952 | 1.0378 | |
| 600MPE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 12224.155 | 0.8832 | 0.7744 | 1.0378 | |
| AU565 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10880.155 | 0.9895 | 0.9862 | 1.5205 | |
| AU565 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10880.155 | 0.9993 | 0.9991 | 1.5205 | |
| AU565 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10880.155 | 0.9865 | 0.9822 | 1.5205 | |
| AU565 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10880.155 | 0.9902 | 0.9871 | 1.5205 | |
| AU565 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10880.155 | 0.9334 | 0.9114 | 1.5205 | |
| AU565 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 10880.155 | 0.6657 | 0.5304 | 1.5205 |