Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00109 | uM | 9972.121 | 1.0705 | 1.1274 | 1.1034 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00546 | uM | 9972.121 | 1.0018 | 1.0032 | 1.1034 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.0273 | uM | 9972.121 | 1.0186 | 1.0337 | 1.1034 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.136 | uM | 9972.121 | 0.9764 | 0.9572 | 1.1034 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.682 | uM | 9972.121 | 0.8168 | 0.6649 | 1.1034 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 3.41 | uM | 9972.121 | 0.6228 | 0.3022 | 1.1034 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 17.1 | uM | 9972.121 | 0.5733 | 0.2080 | 1.1034 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 9972.121 | 0.6137 | 0.2849 | 1.1034 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000218 | uM | 9997.121 | 1.0909 | 1.1628 | 1.1121 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00109 | uM | 9997.121 | 1.0633 | 1.1135 | 1.1121 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00546 | uM | 9997.121 | 1.0316 | 1.0567 | 1.1121 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.0273 | uM | 9997.121 | 1.0333 | 1.0597 | 1.1121 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.136 | uM | 9997.121 | 0.9923 | 0.9861 | 1.1121 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.682 | uM | 9997.121 | 0.8470 | 0.7225 | 1.1121 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 3.41 | uM | 9997.121 | 0.6801 | 0.4140 | 1.1121 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 17.1 | uM | 9997.121 | 0.6110 | 0.2842 | 1.1121 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 9997.121 | 0.6581 | 0.3728 | 1.1121 | |
| 184A1 | NM | Basal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12509.155 | 1.0531 | 1.0785 | 1.3444 | |
| 184A1 | NM | Basal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12509.155 | 0.9647 | 0.9473 | 1.3444 | |
| 184A1 | NM | Basal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12509.155 | 1.0030 | 1.0045 | 1.3444 | |
| 184A1 | NM | Basal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12509.155 | 0.8573 | 0.7836 | 1.3444 | |
| 184A1 | NM | Basal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12509.155 | 0.7379 | 0.5953 | 1.3444 | |
| 184A1 | NM | Basal | Dactolisib | PI3K | PI3K | 0.267 | uM | 12509.155 | 0.5114 | 0.2144 | 1.3444 | |
| 184A1 | NM | Basal | Dactolisib | PI3K | PI3K | 1.33 | uM | 12509.155 | 0.4040 | 0.0191 | 1.3444 | |
| 184A1 | NM | Basal | Dactolisib | PI3K | PI3K | 6.67 | uM | 12509.155 | 0.4400 | 0.0859 | 1.3444 |