Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7931.007 | 1.0395 | 1.0539 | 1.4557 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.118 | uM | 7931.007 | 0.9505 | 0.9314 | 1.4557 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.59 | uM | 7931.007 | 0.9231 | 0.8931 | 1.4557 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 2.95 | uM | 7931.007 | 0.7517 | 0.6439 | 1.4557 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 14.8 | uM | 7931.007 | 0.5861 | 0.3856 | 1.4557 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 73.8 | uM | 7931.007 | 0.4214 | 0.1046 | 1.4557 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7932.043 | 1.0119 | 1.0238 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7932.043 | 1.0022 | 1.0044 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7932.043 | 1.0860 | 1.1722 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7932.043 | 1.0425 | 1.0851 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.118 | uM | 7932.043 | 1.0192 | 1.0384 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.59 | uM | 7932.043 | 0.9627 | 0.9253 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 2.95 | uM | 7932.043 | 0.7528 | 0.5048 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 14.8 | uM | 7932.043 | 0.5257 | 0.0501 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 73.8 | uM | 7932.043 | 0.3585 | -0.2843 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000189 | uM | 9958.034 | 1.0131 | 1.0504 | 0.5217 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000945 | uM | 9958.034 | 0.9986 | 0.9948 | 0.5217 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00472 | uM | 9958.034 | 0.9827 | 0.9341 | 0.5217 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.0236 | uM | 9958.034 | 1.0115 | 1.0443 | 0.5217 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.118 | uM | 9958.034 | 0.9590 | 0.8457 | 0.5217 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.59 | uM | 9958.034 | 0.9063 | 0.6562 | 0.5217 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 2.95 | uM | 9958.034 | 0.7145 | 0.0499 | 0.5217 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 14.8 | uM | 9958.034 | 0.5075 | -0.4550 | 0.5217 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 73.8 | uM | 9958.034 | 0.3727 | -0.6984 | 0.5217 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000218 | uM | 9972.121 | 0.9902 | 0.9822 | 1.1034 |