Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-468 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7907.043 | 1.1036 | 1.1245 | 1.6330 | |
| MDA-MB-468 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7907.043 | 1.0540 | 1.0654 | 1.6330 | |
| MDA-MB-468 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7907.043 | 1.0268 | 1.0327 | 1.6330 | |
| MDA-MB-468 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.118 | uM | 7907.043 | 0.9723 | 0.9659 | 1.6330 | |
| MDA-MB-468 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.59 | uM | 7907.043 | 0.9509 | 0.9393 | 1.6330 | |
| MDA-MB-468 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 2.95 | uM | 7907.043 | 0.9038 | 0.8798 | 1.6330 | |
| MDA-MB-468 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 14.8 | uM | 7907.043 | 1.1012 | 1.1216 | 1.6330 | |
| MDA-MB-468 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 73.8 | uM | 7907.043 | 0.8584 | 0.8215 | 1.6330 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000218 | uM | 9759.121 | 0.9546 | 0.9291 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00109 | uM | 9759.121 | 1.0058 | 1.0090 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00546 | uM | 9759.121 | 0.9230 | 0.8795 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.0273 | uM | 9759.121 | 1.0099 | 1.0154 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.136 | uM | 9759.121 | 1.0299 | 1.0463 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.682 | uM | 9759.121 | 0.7772 | 0.6447 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 3.41 | uM | 9759.121 | 0.4974 | 0.1632 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 17.1 | uM | 9759.121 | 0.1976 | -0.4316 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 9759.121 | 0.0880 | -0.6968 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000218 | uM | 9760.121 | 1.0874 | 1.1700 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00109 | uM | 9760.121 | 0.9690 | 0.9395 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00546 | uM | 9760.121 | 1.0950 | 1.1848 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.0273 | uM | 9760.121 | 1.0213 | 1.0416 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.136 | uM | 9760.121 | 1.0306 | 1.0596 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.682 | uM | 9760.121 | 0.9493 | 0.9011 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 3.41 | uM | 9760.121 | 0.7418 | 0.4950 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 17.1 | uM | 9760.121 | 0.5088 | 0.0355 | 1.0265 |