Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | Chk2 inhibitor II | CHK2 | CHK | 0.00427 | uM | 10642.14 | 0.9070 | 0.6732 | 0.5473 | |
| MDA-MB-175-VII | HR+ | Luminal | Chk2 inhibitor II | CHK2 | CHK | 0.0213 | uM | 10642.14 | 0.9791 | 0.9241 | 0.5473 | |
| MDA-MB-175-VII | HR+ | Luminal | Chk2 inhibitor II | CHK2 | CHK | 0.107 | uM | 10642.14 | 0.9109 | 0.6865 | 0.5473 | |
| MDA-MB-175-VII | HR+ | Luminal | Chk2 inhibitor II | CHK2 | CHK | 0.533 | uM | 10642.14 | 0.9261 | 0.7383 | 0.5473 | |
| MDA-MB-175-VII | HR+ | Luminal | Chk2 inhibitor II | CHK2 | CHK | 2.67 | uM | 10642.14 | 0.9293 | 0.7491 | 0.5473 | |
| MDA-MB-175-VII | HR+ | Luminal | Chk2 inhibitor II | CHK2 | CHK | 13.3 | uM | 10642.14 | 0.9139 | 0.6967 | 0.5473 | |
| MDA-MB-175-VII | HR+ | Luminal | Chk2 inhibitor II | CHK2 | CHK | 66.7 | uM | 10642.14 | 0.6682 | -0.0424 | 0.5473 | |
| MDA-MB-361 | HER2amp | Luminal | Chk2 inhibitor II | CHK2 | CHK | 0.000171 | uM | 10643.14 | 0.9885 | 0.9548 | 0.5078 | |
| MDA-MB-361 | HER2amp | Luminal | Chk2 inhibitor II | CHK2 | CHK | 0.000853 | uM | 10643.14 | 1.0643 | 1.2614 | 0.5078 | |
| MDA-MB-361 | HER2amp | Luminal | Chk2 inhibitor II | CHK2 | CHK | 0.00427 | uM | 10643.14 | 0.9860 | 0.9452 | 0.5078 | |
| MDA-MB-361 | HER2amp | Luminal | Chk2 inhibitor II | CHK2 | CHK | 0.0213 | uM | 10643.14 | 1.0570 | 1.2306 | 0.5078 | |
| MDA-MB-361 | HER2amp | Luminal | Chk2 inhibitor II | CHK2 | CHK | 0.107 | uM | 10643.14 | 1.0760 | 1.3104 | 0.5078 | |
| MDA-MB-361 | HER2amp | Luminal | Chk2 inhibitor II | CHK2 | CHK | 0.533 | uM | 10643.14 | 1.0194 | 1.0771 | 0.5078 | |
| MDA-MB-361 | HER2amp | Luminal | Chk2 inhibitor II | CHK2 | CHK | 2.67 | uM | 10643.14 | 0.9718 | 0.8903 | 0.5078 | |
| MDA-MB-361 | HER2amp | Luminal | Chk2 inhibitor II | CHK2 | CHK | 13.3 | uM | 10643.14 | 0.8832 | 0.5661 | 0.5078 | |
| MDA-MB-361 | HER2amp | Luminal | Chk2 inhibitor II | CHK2 | CHK | 66.7 | uM | 10643.14 | 0.6754 | -0.0766 | 0.5078 | |
| MX1 | Unknown | Unknown | Chk2 inhibitor II | CHK2 | CHK | 0.000171 | uM | 10644.14 | 1.0449 | 1.2148 | 0.4302 | |
| MX1 | Unknown | Unknown | Chk2 inhibitor II | CHK2 | CHK | 0.000853 | uM | 10644.14 | 0.9875 | 0.9423 | 0.4302 | |
| MX1 | Unknown | Unknown | Chk2 inhibitor II | CHK2 | CHK | 0.00427 | uM | 10644.14 | 0.9771 | 0.8950 | 0.4302 | |
| MX1 | Unknown | Unknown | Chk2 inhibitor II | CHK2 | CHK | 0.0213 | uM | 10644.14 | 1.0449 | 1.2148 | 0.4302 | |
| MX1 | Unknown | Unknown | Chk2 inhibitor II | CHK2 | CHK | 0.107 | uM | 10644.14 | 1.0461 | 1.2210 | 0.4302 | |
| MX1 | Unknown | Unknown | Chk2 inhibitor II | CHK2 | CHK | 0.533 | uM | 10644.14 | 1.0068 | 1.0319 | 0.4302 | |
| MX1 | Unknown | Unknown | Chk2 inhibitor II | CHK2 | CHK | 2.67 | uM | 10644.14 | 1.0093 | 1.0437 | 0.4302 | |
| MX1 | Unknown | Unknown | Chk2 inhibitor II | CHK2 | CHK | 13.3 | uM | 10644.14 | 0.9871 | 0.9404 | 0.4302 | |
| MX1 | Unknown | Unknown | Chk2 inhibitor II | CHK2 | CHK | 66.7 | uM | 10644.14 | 0.5404 | -0.5217 | 0.4302 |