Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0862 | uM | 9536.011 | 1.0275 | 1.0434 | 1.2640 | |
| LY2 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.431 | uM | 9536.011 | 1.0055 | 1.0087 | 1.2640 | |
| LY2 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 2.15 | uM | 9536.011 | 0.9951 | 0.9922 | 1.2640 | |
| LY2 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10.8 | uM | 9536.011 | 0.7270 | 0.5541 | 1.2640 | |
| LY2 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 53.9 | uM | 9536.011 | 0.7753 | 0.6352 | 1.2640 | |
| LY2 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 9536.011 | 0.2486 | -0.3352 | 1.2640 | |
| LY2 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 9536.011 | 0.0222 | -0.9018 | 1.2640 | |
| LY2 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 10264.011 | 0.9779 | 0.9682 | 1.3983 | |
| LY2 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0172 | uM | 10264.011 | 1.0404 | 1.0574 | 1.3983 | |
| LY2 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0862 | uM | 10264.011 | 0.9558 | 0.9364 | 1.3983 | |
| LY2 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.431 | uM | 10264.011 | 0.9786 | 0.9693 | 1.3983 | |
| LY2 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 2.15 | uM | 10264.011 | 0.9444 | 0.9198 | 1.3983 | |
| LY2 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10.8 | uM | 10264.011 | 0.9157 | 0.8779 | 1.3983 | |
| LY2 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 53.9 | uM | 10264.011 | 0.6811 | 0.5197 | 1.3983 | |
| LY2 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 10264.011 | 0.2052 | -0.3557 | 1.3983 | |
| LY2 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 10264.011 | 0.1007 | -0.6128 | 1.3983 | |
| MCF 10A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 7867.011 | 1.0243 | 1.0204 | 2.3684 | |
| MCF 10A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0172 | uM | 7867.011 | 1.1033 | 1.0847 | 2.3684 | |
| MCF 10A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0862 | uM | 7867.011 | 0.9738 | 0.9777 | 2.3684 | |
| MCF 10A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.431 | uM | 7867.011 | 1.0701 | 1.0580 | 2.3684 | |
| MCF 10A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 2.15 | uM | 7867.011 | 1.0468 | 1.0390 | 2.3684 | |
| MCF 10A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 10.8 | uM | 7867.011 | 0.8824 | 0.8971 | 2.3684 | |
| MCF 10A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 53.9 | uM | 7867.011 | 0.6423 | 0.6590 | 2.3684 | |
| MCF 10A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 7867.011 | 0.1444 | -0.1165 | 2.3684 | |
| MCF 10A | NM | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 7867.011 | 0.0062 | -0.7660 | 2.3684 |