Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 10380.066 | 0.9885 | 0.9812 | 1.2245 | |
| LY2 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.000427 | uM | 10380.066 | 1.1544 | 1.2488 | 1.2245 | |
| LY2 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 10380.066 | 1.1189 | 1.1922 | 1.2245 | |
| LY2 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0107 | uM | 10380.066 | 1.1061 | 1.1717 | 1.2245 | |
| LY2 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0533 | uM | 10380.066 | 1.0386 | 1.0628 | 1.2245 | |
| LY2 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.267 | uM | 10380.066 | 1.0892 | 1.1445 | 1.2245 | |
| LY2 | HR+ | Luminal | AG1024 | IGF1R | RTK | 1.33 | uM | 10380.066 | 1.0552 | 1.0896 | 1.2245 | |
| LY2 | HR+ | Luminal | AG1024 | IGF1R | RTK | 6.67 | uM | 10380.066 | 1.0851 | 1.1380 | 1.2245 | |
| LY2 | HR+ | Luminal | AG1024 | IGF1R | RTK | 33.3 | uM | 10380.066 | 1.0535 | 1.0869 | 1.2245 | |
| MB 157 | Unknown | Unknown | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7482.066 | 0.8368 | 0.7093 | 1.1347 | |
| MB 157 | Unknown | Unknown | AG1024 | IGF1R | RTK | 0.000427 | uM | 7482.066 | 0.9874 | 0.9777 | 1.1347 | |
| MB 157 | Unknown | Unknown | AG1024 | IGF1R | RTK | 0.00213 | uM | 7482.066 | 1.1178 | 1.2063 | 1.1347 | |
| MB 157 | Unknown | Unknown | AG1024 | IGF1R | RTK | 0.0107 | uM | 7482.066 | 0.8577 | 0.7469 | 1.1347 | |
| MB 157 | Unknown | Unknown | AG1024 | IGF1R | RTK | 0.0533 | uM | 7482.066 | 1.0258 | 1.0455 | 1.1347 | |
| MB 157 | Unknown | Unknown | AG1024 | IGF1R | RTK | 0.267 | uM | 7482.066 | 0.9630 | 0.9347 | 1.1347 | |
| MB 157 | Unknown | Unknown | AG1024 | IGF1R | RTK | 1.33 | uM | 7482.066 | 1.1505 | 1.2630 | 1.1347 | |
| MB 157 | Unknown | Unknown | AG1024 | IGF1R | RTK | 6.67 | uM | 7482.066 | 1.0699 | 1.1226 | 1.1347 | |
| MB 157 | Unknown | Unknown | AG1024 | IGF1R | RTK | 33.3 | uM | 7482.066 | 1.4115 | 1.7098 | 1.1347 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7483.066 | 0.9965 | 0.9978 | 3.2636 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 0.000427 | uM | 7483.066 | 0.9364 | 0.9601 | 3.2636 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 0.00213 | uM | 7483.066 | 1.0016 | 1.0010 | 3.2636 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 0.0107 | uM | 7483.066 | 1.0378 | 1.0229 | 3.2636 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 0.0533 | uM | 7483.066 | 0.9838 | 0.9900 | 3.2636 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 0.267 | uM | 7483.066 | 0.9346 | 0.9590 | 3.2636 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 1.33 | uM | 7483.066 | 0.8943 | 0.9327 | 3.2636 |