LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 10 of 15: Cell count and normalized growth rate inhibition values within biological replicate 3. - Dataset (ID:20247)

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Cell Small Molecule Small Mol Concentration Small Mol Conc Unit LJP Library Plate Replicate Assay Well Timepoint Timepoint Unit Total Cell Count Before Treatment Total Cell Count After Treatment Total Control Cell Count Relative Cell Count Normalized Growth Rate Inhibition Value
MDA-MB-231 Dactolisib
10
uM
LJP5
 1
M13
 72
hr
 1235 1621 4474 0.3623 0.1573
MDA-MB-231 Dactolisib
10
uM
LJP5
 2
M13
 72
hr
 1235 1599 4578 0.3492 0.1460
MDA-MB-231 Dactolisib
10
uM
LJP5
 3
M13
 72
hr
 1235 1716 4929 0.3481 0.1787
MDA-MB-231 Alpelisib
0.04
uM
LJP5
 1
N06
 72
hr
 1235 3872 4474 0.8653 0.8500
MDA-MB-231 Alpelisib
0.04
uM
LJP5
 2
N06
 72
hr
 1235 4172 4578 0.9112 0.9039
MDA-MB-231 Alpelisib
0.04
uM
LJP5
 3
N06
 72
hr
 1235 5118 4929 1.0383 1.0380
MDA-MB-231 Alpelisib
0.12
uM
LJP5
 1
N05
 72
hr
 1235 4036 4474 0.9020 0.8919
MDA-MB-231 Alpelisib
0.12
uM
LJP5
 2
N05
 72
hr
 1235 4197 4578 0.9167 0.9100
MDA-MB-231 Alpelisib
0.12
uM
LJP5
 3
N05
 72
hr
 1235 5085 4929 1.0316 1.0314
MDA-MB-231 Alpelisib
0.37
uM
LJP5
 1
N04
 72
hr
 1235 3887 4474 0.8687 0.8539
MDA-MB-231 Alpelisib
0.37
uM
LJP5
 2
N04
 72
hr
 1235 4233 4578 0.9245 0.9186
MDA-MB-231 Alpelisib
0.37
uM
LJP5
 3
N04
 72
hr
 1235 4702 4929 0.9539 0.9533
MDA-MB-231 Alpelisib
1.11
uM
LJP5
 1
N03
 72
hr
 1235 3932 4474 0.8787 0.8654
MDA-MB-231 Alpelisib
1.11
uM
LJP5
 2
N03
 72
hr
 1235 4112 4578 0.8981 0.8894
MDA-MB-231 Alpelisib
1.11
uM
LJP5
 3
N03
 72
hr
 1235 4635 4929 0.9403 0.9393
MDA-MB-231 Alpelisib
3.33
uM
LJP5
 1
N02
 72
hr
 1235 4080 4474 0.9118 0.9029
MDA-MB-231 Alpelisib
3.33
uM
LJP5
 2
N02
 72
hr
 1235 3980 4578 0.8693 0.8571
MDA-MB-231 Alpelisib
3.33
uM
LJP5
 3
N02
 72
hr
 1235 4687 4929 0.9509 0.9501
MDA-MB-231 Alpelisib
10
uM
LJP5
 1
N01
 72
hr
 1235 3378 4474 0.7549 0.7189
MDA-MB-231 Alpelisib
10
uM
LJP5
 2
N01
 72
hr
 1235 3459 4578 0.7555 0.7241
MDA-MB-231 Alpelisib
10
uM
LJP5
 3
N01
 72
hr
 1235 3890 4929 0.7892 0.7763
MDA-MB-231 GDC-0980
0.04
uM
LJP5
 1
K24
 72
hr
 1235 3172 4474 0.7089 0.6616
MDA-MB-231 GDC-0980
0.04
uM
LJP5
 2
K24
 72
hr
 1235 3201 4578 0.6991 0.6548
MDA-MB-231 GDC-0980
0.04
uM
LJP5
 3
K24
 72
hr
 1235 3220 4929 0.6532 0.6157
MDA-MB-231 GDC-0980
0.12
uM
LJP5
 1
K23
 72
hr
 1235 2459 4474 0.5495 0.4486