High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)
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| Cell | SM Name | Small Mol Concentration | Small Mol Conc Unit | Other Reagent 1 Name | Other Reagent 1 Detection Channel | Other Reagent 2 Name | Other Reagent 2 Detection Channel | Row | Column | Field | X-coordinate | Y-coordinate | Image | Nuclear area (pixels) | Cytoplasm area (pixels) | Nuclear intensity (AU) | Std Dev of nuclear intensity (AU) | Cytoplasm intensity (AU) | Std Dev of cytoplasm intensity (AU) | 10% quantile of nuclear intensity (AU) | 20% quantile of nuclear intensity (AU) | 30% quantile of nuclear intensity (AU) | 40% quantile of nuclear intensity (AU) | 50% quantile of nuclear intensity (AU) | 60% quantile of nuclear intensity (AU) | 70% quantile of nuclear intensity (AU) | 80% quantile of nuclear intensity (AU) | 90% quantile of nuclear intensity (AU) | Ratio of cytoplasm perimeter to area | Cytoplasm perimeter (pixels) | Nuclear roundness | Nuclear length (pixels) | Nuclear halfwidth (pixels) | Number of nuclei | Ratio of nuclear perimeter to area | Nuclear perimeter (pixels) | Nuclear Haralick ASM | Nuclear Haralick contrast | Nuclear Haralick entropy | Nuclear Haralick IDM | Nuclear Haralick moment 2 | Nuclear Haralick moment 3 | Nuclear Haralick moment 4 | Nuclear Haralick moment 5 | Nuclear radial moment (border) | Nuclear radial moment (center) | Nuclear Threshold Adj Stat 1 (Threshold: 0.2) | Nuclear Threshold Adj Stat 1 (Threshold: 0.4) | Nuclear Threshold Adj Stat 2 (Threshold: 0.2) | Nuclear Threshold Adj Stat 2 (Threshold: 0.4) | Nuclear Threshold Adj Stat 3 (Threshold: 0.2) | Nuclear Threshold Adj Stat 3 (Threshold: 0.4) | Nuclear Threshold Adj Stat 4 (Threshold: 0.2) | Nuclear Threshold Adj Stat 4 (Threshold: 0.4) | Nuclear Threshold Adj Stat 5 (Threshold: 0.2) | Nuclear Threshold Adj Stat 5 (Threshold: 0.4) | Nuclear Threshold Adj Stat 6 (Threshold: 0.2) | Nuclear Threshold Adj Stat 6 (Threshold: 0.4) | Nuclear Threshold Adj Stat 7 (Threshold: 0.2) | Nuclear Threshold Adj Stat 7 (Threshold: 0.4) | Nuclear Threshold Adj Stat 8 (Threshold: 0.2) | Nuclear Threshold Adj Stat 8 (Threshold: 0.4) | Nuclear Threshold Adj Stat 9 (Threshold: 0.2) | Nuclear Threshold Adj Stat 9 (Threshold: 0.4) | Nuclear Threshold Adj Stat 10 (Threshold: 0.2) | Nuclear Threshold Adj Stat 10 (Threshold: 0.4) | Nuclear Threshold Adj Stat 11 (Threshold: 0.2) | Nuclear Threshold Adj Stat 11 (Threshold: 0.4) | Nuclear Threshold Adj Stat 12 (Threshold: 0.2) | Nuclear Threshold Adj Stat 12 (Threshold: 0.4) | Nuclear Threshold Adj Stat 13 (Threshold: 0.2) | Nuclear Threshold Adj Stat 13 (Threshold: 0.4) | Nuclear Threshold Adj Stat 14 (Threshold: 0.2) | Nuclear Threshold Adj Stat 14 (Threshold: 0.4) | Nuclear Threshold Adj Stat 15 (Threshold: 0.2) | Nuclear Threshold Adj Stat 15 (Threshold: 0.4) | Nuclear Threshold Adj Stat 16 (Threshold: 0.2) | Nuclear Threshold Adj Stat 16 (Threshold: 0.4) | Nuclear Threshold Adj Stat 17 (Threshold: 0.2) | Nuclear Threshold Adj Stat 17 (Threshold: 0.4) | Nuclear Threshold Adj Stat 18 (Threshold: 0.2) | Nuclear Threshold Adj Stat 18 (Threshold: 0.4) | Nuclear Threshold Adj Stat 19 (Threshold: 0.2) | Nuclear Threshold Adj Stat 19 (Threshold: 0.4) | Nuclear Threshold Adj Stat 20 (Threshold: 0.2) | Nuclear Threshold Adj Stat 20 (Threshold: 0.4) | Nuclear Threshold Adj Stat 21 (Threshold: 0.2) | Nuclear Threshold Adj Stat 21 (Threshold: 0.4) | Nuclear Threshold Adj Stat 22 (Threshold: 0.2) | Nuclear Threshold Adj Stat 22 (Threshold: 0.4) | Nuclear Threshold Adj Stat 23 (Threshold: 0.2) | Nuclear Threshold Adj Stat 23 (Threshold: 0.4) | Nuclear Threshold Adj Stat 24 (Threshold: 0.2) | Nuclear Threshold Adj Stat 24 (Threshold: 0.4) | Nuclear Threshold Adj Stat 25 (Threshold: 0.2) | Nuclear Threshold Adj Stat 25 (Threshold: 0.4) | Nuclear Threshold Adj Stat 26 (Threshold: 0.2) | Nuclear Threshold Adj Stat 26 (Threshold: 0.4) | Nuclear Threshold Adj Stat 27 (Threshold: 0.2) | Nuclear Threshold Adj Stat 27 (Threshold: 0.4) | Nuclear Threshold Adj Stat 28 | Nuclear Threshold Adj Stat 29 | Nuclear Threshold Adj Stat 30 | Nuclear Threshold Adj Stat 31 | Nuclear Threshold Adj Stat 32 | Nuclear Threshold Adj Stat 33 | Nuclear Threshold Adj Stat 34 | Nuclear Threshold Adj Stat 35 | Nuclear Threshold Adj Stat 36 | 10% quantile of cytoplasm intensity (AU) | 20% quantile of cytoplasm intensity (AU) | 30% quantile of cytoplasm intensity (AU) | 40% quantile of cytoplasm intensity (AU) | 50% quantile of cytoplasm intensity (AU) | 60% quantile of cytoplasm intensity (AU) | 70% quantile of cytoplasm intensity (AU) | 80% quantile of cytoplasm intensity (AU) | 90% quantile of cytoplasm intensity (AU) | Cytoplasmic Haralick ASM | Cytoplasmic Haralick contrast | Cytoplasmic Haralick entropy | Cytoplasmic Haralick IDM | Cytoplasmic Haralick moment 2 | Cytoplasmic Haralick moment 3 | Cytoplasmic Haralick moment 4 | Cytoplasmic Haralick moment 5 | Cytoplasmic radial moment (border) | Cytoplasmic radial moment (center) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 28 | Cytoplasmic Threshold Adj Stat 29 | Cytoplasmic Threshold Adj Stat 30 | Cytoplasmic Threshold Adj Stat 31 | Cytoplasmic Threshold Adj Stat 32 | Cytoplasmic Threshold Adj Stat 33 | Cytoplasmic Threshold Adj Stat 34 | Cytoplasmic Threshold Adj Stat 35 | Cytoplasmic Threshold Adj Stat 36 |
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| BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 923 | 749 | | 18485 | 19144 | 337.4 | 48.91 | 148.53 | 162.19 | 268 | 300 | 318 | 331 | 344 | 355 | 367 | 380 | 396 | 0.0705 | 1349 | 1.142 | 100.72 | 39.20 | 2 | 0.0147 | 271 | 0.0025 | 9.90 | 6.327 | 0.3429 | 116234.0 | 40800000 | 14500000000 | 5230000000000 | 0.4218 | 0.2181 | 0.0005 | 0.0000 | 0.0012 | 0.0001 | 0.0027 | 0.0001 | 0.0083 | 0.0008 | 0.0174 | 0.0071 | 0.0285 | 0.0145 | 0.0316 | 0.0074 | 0.0551 | 0.0119 | 0.8546 | 0.9581 | 0.0001 | 0.0000 | 0.0000 | 0.0001 | 0.0005 | 0.0001 | 0.0022 | 0.0008 | 0.0085 | 0.0071 | 0.0136 | 0.0145 | 0.0122 | 0.0074 | 0.0186 | 0.0119 | 0.9443 | 0.9581 | 0.0326 | 0.0000 | 0.0692 | 0.0000 | 0.0794 | 0.0000 | 0.1090 | 0.0000 | 0.1517 | 0.0000 | 0.1415 | 0.0000 | 0.1395 | 0.0000 | 0.1446 | 0.0000 | 0.1324 | 0.0000 | 0.0028 | 0.0050 | 0.0091 | 0.0138 | 0.0293 | 0.0412 | 0.0457 | 0.0737 | 0.7793 | 23 | 31 | 42 | 57 | 77 | 109 | 167 | 256 | 387 | 0.0183 | 13.36 | 5.441 | 0.5104 | 48364.8 | 22700000 | 12800000000 | 8140000000000 | 0.3890 | 0.2609 | 0.0233 | 0.0013 | 0.0952 | 0.0085 | 0.1700 | 0.0530 | 0.1578 | 0.1011 | 0.1966 | 0.1512 | 0.1445 | 0.1702 | 0.0908 | 0.1386 | 0.0714 | 0.1404 | 0.0504 | 0.2358 | 0.0001 | 0.0003 | 0.0008 | 0.0009 | 0.0026 | 0.0044 | 0.0128 | 0.0124 | 0.0492 | 0.0417 | 0.0708 | 0.0661 | 0.0547 | 0.0448 | 0.0827 | 0.0706 | 0.7262 | 0.7587 | 0.0007 | 0.0006 | 0.0009 | 0.0017 | 0.0035 | 0.0058 | 0.0196 | 0.0235 | 0.0581 | 0.0707 | 0.0989 | 0.0946 | 0.0629 | 0.0773 | 0.0941 | 0.1006 | 0.6612 | 0.6252 | 0.0000 | 0.0010 | 0.0043 | 0.0159 | 0.0522 | 0.0864 | 0.0570 | 0.0870 | 0.6963 |
| MDA-MB-231 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 305 | 753 | | 14531 | 31502 | 446.4 | 61.03 | 117.13 | 162.48 | 365 | 402 | 424 | 439 | 452 | 464 | 476 | 491 | 515 | 0.0488 | 1538 | 0.844 | 110.02 | 27.80 | 4 | 0.0189 | 274 | 0.0017 | 18.96 | 6.823 | 0.2707 | 202963.0 | 93800000 | 44000000000 | 21000000000000 | 0.4307 | 0.2135 | 0.0003 | 0.0001 | 0.0001 | 0.0000 | 0.0009 | 0.0000 | 0.0036 | 0.0001 | 0.0149 | 0.0077 | 0.0284 | 0.0166 | 0.0253 | 0.0080 | 0.0383 | 0.0128 | 0.8882 | 0.9547 | 0.0001 | 0.0001 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0019 | 0.0001 | 0.0098 | 0.0077 | 0.0186 | 0.0166 | 0.0149 | 0.0080 | 0.0188 | 0.0117 | 0.9360 | 0.9558 | 0.0148 | 1.0000 | 0.0239 | 0.0000 | 0.0091 | 0.0000 | 0.0262 | 0.0000 | 0.0809 | 0.0000 | 0.0945 | 0.0000 | 0.0809 | 0.0000 | 0.1173 | 0.0000 | 0.5524 | 0.0000 | 0.0022 | 0.0070 | 0.0123 | 0.0187 | 0.0346 | 0.0523 | 0.0642 | 0.0921 | 0.7167 | 13 | 16 | 21 | 33 | 52 | 79 | 118 | 180 | 305 | 0.0400 | 19.55 | 4.937 | 0.5597 | 40119.5 | 22800000 | 16800000000 | 14600000000000 | 0.4801 | 0.1897 | 0.0180 | 0.0019 | 0.0684 | 0.0102 | 0.1417 | 0.0304 | 0.1389 | 0.0605 | 0.1660 | 0.1385 | 0.1648 | 0.1775 | 0.1107 | 0.1263 | 0.1041 | 0.1394 | 0.0873 | 0.3154 | 0.0012 | 0.0003 | 0.0022 | 0.0020 | 0.0034 | 0.0030 | 0.0115 | 0.0124 | 0.0463 | 0.0387 | 0.0745 | 0.0614 | 0.0495 | 0.0472 | 0.0766 | 0.0656 | 0.7348 | 0.7694 | 0.0005 | 0.0007 | 0.0024 | 0.0020 | 0.0066 | 0.0068 | 0.0187 | 0.0217 | 0.0585 | 0.0622 | 0.0953 | 0.1084 | 0.0633 | 0.0699 | 0.0954 | 0.0979 | 0.6595 | 0.6304 | 0.0004 | 0.0017 | 0.0044 | 0.0151 | 0.0498 | 0.0888 | 0.0599 | 0.0831 | 0.6968 |
| BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1097 | 888 | | 12238 | 26075 | 289.7 | 37.50 | 189.36 | 227.04 | 244 | 259 | 270 | 279 | 288 | 297 | 306 | 319 | 339 | 0.0439 | 1145 | 0.830 | 88.09 | 22.20 | 1 | 0.0187 | 229 | 0.0028 | 13.76 | 6.262 | 0.2992 | 85311.3 | 25500000 | 7770000000 | 2410000000000 | 0.4323 | 0.2203 | 0.0001 | 0.0000 | 0.0006 | 0.0000 | 0.0020 | 0.0000 | 0.0060 | 0.0003 | 0.0185 | 0.0078 | 0.0396 | 0.0156 | 0.0439 | 0.0098 | 0.0748 | 0.0169 | 0.8146 | 0.9496 | 0.0000 | 0.0000 | 0.0001 | 0.0000 | 0.0004 | 0.0000 | 0.0019 | 0.0001 | 0.0111 | 0.0076 | 0.0227 | 0.0147 | 0.0220 | 0.0071 | 0.0372 | 0.0112 | 0.9046 | 0.9593 | 0.0133 | 0.0000 | 0.0200 | 0.0000 | 0.0333 | 0.0000 | 0.0765 | 0.0000 | 0.1109 | 0.0000 | 0.1408 | 0.0000 | 0.1264 | 0.0000 | 0.1574 | 0.0000 | 0.3215 | 0.0000 | 0.0025 | 0.0088 | 0.0142 | 0.0239 | 0.0616 | 0.0902 | 0.0999 | 0.1291 | 0.5696 | 14 | 17 | 21 | 38 | 82 | 149 | 243 | 368 | 535 | 0.0346 | 41.52 | 5.730 | 0.4531 | 87402.9 | 53700000 | 38800000000 | 31400000000000 | 0.4360 | 0.2156 | 0.0618 | 0.0023 | 0.2087 | 0.0236 | 0.2420 | 0.1370 | 0.1346 | 0.1541 | 0.1098 | 0.1754 | 0.0927 | 0.1578 | 0.0590 | 0.0979 | 0.0495 | 0.0906 | 0.0418 | 0.1614 | 0.0001 | 0.0003 | 0.0003 | 0.0006 | 0.0015 | 0.0013 | 0.0103 | 0.0092 | 0.0495 | 0.0407 | 0.0808 | 0.0715 | 0.0648 | 0.0501 | 0.0944 | 0.0787 | 0.6983 | 0.7478 | 0.0000 | 0.0003 | 0.0007 | 0.0015 | 0.0026 | 0.0033 | 0.0159 | 0.0223 | 0.0664 | 0.0710 | 0.1136 | 0.1319 | 0.0845 | 0.0978 | 0.1225 | 0.1311 | 0.5939 | 0.5409 | 0.0004 | 0.0007 | 0.0021 | 0.0134 | 0.0562 | 0.0948 | 0.0755 | 0.1060 | 0.6510 |
| SK-BR-3 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 518 | 503 | | 15648 | 56021 | 320.9 | 59.50 | 142.33 | 181.99 | 244 | 279 | 299 | 315 | 329 | 341 | 354 | 368 | 389 | 0.0239 | 1341 | 0.987 | 126.85 | 36.01 | 1 | 0.0202 | 316 | 0.0015 | 21.65 | 6.855 | 0.2488 | 106538.0 | 36300000 | 12600000000 | 4480000000000 | 0.4413 | 0.2040 | 0.0005 | 0.0000 | 0.0005 | 0.0000 | 0.0020 | 0.0000 | 0.0079 | 0.0003 | 0.0295 | 0.0078 | 0.0562 | 0.0157 | 0.0615 | 0.0104 | 0.0915 | 0.0162 | 0.7503 | 0.9496 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0023 | 0.0003 | 0.0109 | 0.0075 | 0.0242 | 0.0143 | 0.0210 | 0.0081 | 0.0316 | 0.0119 | 0.9098 | 0.9580 | 0.0090 | 0.0536 | 0.0157 | 0.0179 | 0.0336 | 0.1429 | 0.0745 | 0.2143 | 0.1272 | 0.1429 | 0.1557 | 0.1607 | 0.1429 | 0.1071 | 0.1597 | 0.0357 | 0.2818 | 0.1250 | 0.0008 | 0.0025 | 0.0050 | 0.0158 | 0.0410 | 0.0684 | 0.0815 | 0.0977 | 0.6873 | 8 | 10 | 12 | 18 | 51 | 108 | 178 | 269 | 424 | 0.1076 | 16.66 | 4.969 | 0.5393 | 53375.8 | 26600000 | 15300000000 | 9680000000000 | 0.3694 | 0.2725 | 0.0166 | 0.0013 | 0.1012 | 0.0060 | 0.2168 | 0.0361 | 0.1910 | 0.0912 | 0.1770 | 0.1724 | 0.1403 | 0.2115 | 0.0824 | 0.1547 | 0.0457 | 0.1475 | 0.0291 | 0.1792 | 0.0006 | 0.0002 | 0.0006 | 0.0006 | 0.0027 | 0.0015 | 0.0085 | 0.0065 | 0.0354 | 0.0299 | 0.0682 | 0.0565 | 0.0555 | 0.0459 | 0.0719 | 0.0641 | 0.7567 | 0.7947 | 0.0005 | 0.0005 | 0.0022 | 0.0022 | 0.0040 | 0.0048 | 0.0126 | 0.0154 | 0.0463 | 0.0551 | 0.0837 | 0.0934 | 0.0695 | 0.0743 | 0.0862 | 0.0911 | 0.6950 | 0.6633 | 0.0005 | 0.0017 | 0.0041 | 0.0114 | 0.0416 | 0.0737 | 0.0613 | 0.0797 | 0.7260 |
| SK-BR-3 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 969 | 728 | | 16378 | 49009 | 195.5 | 37.68 | 203.96 | 331.62 | 151 | 169 | 180 | 189 | 198 | 206 | 215 | 226 | 241 | 0.0278 | 1362 | 1.188 | 93.09 | 34.48 | 1 | 0.0143 | 235 | 0.0032 | 12.80 | 6.161 | 0.3225 | 39638.5 | 8270000 | 1770000000 | 387000000000 | 0.4222 | 0.2262 | 0.0002 | 0.0000 | 0.0012 | 0.0000 | 0.0037 | 0.0000 | 0.0129 | 0.0003 | 0.0346 | 0.0080 | 0.0661 | 0.0181 | 0.0824 | 0.0160 | 0.1152 | 0.0268 | 0.6836 | 0.9309 | 0.0001 | 0.0000 | 0.0003 | 0.0000 | 0.0008 | 0.0000 | 0.0036 | 0.0001 | 0.0120 | 0.0068 | 0.0260 | 0.0139 | 0.0283 | 0.0069 | 0.0418 | 0.0107 | 0.8870 | 0.9616 | 0.0089 | 0.0576 | 0.0166 | 0.0995 | 0.0426 | 0.1047 | 0.0736 | 0.1780 | 0.1192 | 0.1937 | 0.1473 | 0.1675 | 0.1256 | 0.0733 | 0.1456 | 0.0890 | 0.3206 | 0.0366 | 0.0012 | 0.0027 | 0.0072 | 0.0202 | 0.0501 | 0.0834 | 0.0821 | 0.1197 | 0.6333 | 7 | 8 | 10 | 12 | 17 | 54 | 192 | 390 | 701 | 0.1432 | 35.53 | 4.788 | 0.5519 | 151568.0 | 149000000 | 169000000000 | 211000000000000 | 0.4292 | 0.2197 | 0.0529 | 0.0035 | 0.2034 | 0.0131 | 0.2775 | 0.1127 | 0.1544 | 0.1604 | 0.1262 | 0.2014 | 0.0909 | 0.1979 | 0.0516 | 0.1081 | 0.0322 | 0.1003 | 0.0110 | 0.1027 | 0.0001 | 0.0001 | 0.0003 | 0.0001 | 0.0010 | 0.0003 | 0.0081 | 0.0057 | 0.0395 | 0.0371 | 0.0691 | 0.0641 | 0.0487 | 0.0414 | 0.0700 | 0.0648 | 0.7633 | 0.7864 | 0.0004 | 0.0003 | 0.0011 | 0.0011 | 0.0028 | 0.0036 | 0.0129 | 0.0138 | 0.0452 | 0.0466 | 0.0753 | 0.0825 | 0.0565 | 0.0561 | 0.0729 | 0.0789 | 0.7329 | 0.7170 | 0.0001 | 0.0013 | 0.0022 | 0.0102 | 0.0423 | 0.0730 | 0.0512 | 0.0723 | 0.7473 |
| MDA-MB-231 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 200 | 513 | | 11296 | 11224 | 660.4 | 94.02 | 95.02 | 136.71 | 543 | 587 | 617 | 640 | 661 | 683 | 708 | 735 | 774 | 0.1009 | 1133 | 0.918 | 133.74 | 44.91 | 2 | 0.0313 | 353 | 0.0006 | 79.90 | 7.739 | 0.1635 | 444990.0 | 305000000 | 213000000000 | 152000000000000 | 0.4251 | 0.2228 | 0.0000 | 0.0000 | 0.0005 | 0.0000 | 0.0017 | 0.0000 | 0.0042 | 0.0006 | 0.0187 | 0.0081 | 0.0399 | 0.0182 | 0.0436 | 0.0113 | 0.0656 | 0.0181 | 0.8257 | 0.9436 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0006 | 0.0000 | 0.0022 | 0.0004 | 0.0107 | 0.0077 | 0.0240 | 0.0167 | 0.0219 | 0.0084 | 0.0314 | 0.0139 | 0.9090 | 0.9530 | 0.0074 | 0.0816 | 0.0173 | 0.0204 | 0.0222 | 0.0408 | 0.0937 | 0.2245 | 0.0912 | 0.2245 | 0.1307 | 0.2041 | 0.1097 | 0.0816 | 0.1233 | 0.1224 | 0.4044 | 0.0000 | 0.0016 | 0.0026 | 0.0092 | 0.0209 | 0.0527 | 0.0772 | 0.0800 | 0.1071 | 0.6486 | 12 | 16 | 20 | 27 | 38 | 53 | 81 | 138 | 272 | 0.0564 | 8.94 | 4.344 | 0.6275 | 27717.6 | 13300000 | 8080000000 | 5720000000000 | 0.4886 | 0.1747 | 0.0110 | 0.0020 | 0.0386 | 0.0109 | 0.0684 | 0.0288 | 0.1323 | 0.0387 | 0.2183 | 0.1107 | 0.1940 | 0.1846 | 0.1147 | 0.1166 | 0.1422 | 0.1509 | 0.0805 | 0.3568 | 0.0009 | 0.0007 | 0.0031 | 0.0037 | 0.0037 | 0.0072 | 0.0119 | 0.0120 | 0.0417 | 0.0400 | 0.0716 | 0.0744 | 0.0409 | 0.0423 | 0.0707 | 0.0596 | 0.7555 | 0.7601 | 0.0008 | 0.0004 | 0.0011 | 0.0022 | 0.0042 | 0.0043 | 0.0168 | 0.0173 | 0.0348 | 0.0381 | 0.0880 | 0.0934 | 0.0513 | 0.0510 | 0.0677 | 0.0636 | 0.7353 | 0.7297 | 0.0007 | 0.0010 | 0.0036 | 0.0116 | 0.0416 | 0.0819 | 0.0459 | 0.0714 | 0.7423 |
| MDA-MB-231 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 708 | 397 | | 15447 | 27394 | 562.4 | 113.78 | 118.30 | 212.73 | 394 | 458 | 507 | 542 | 576 | 606 | 636 | 667 | 703 | 0.0495 | 1356 | 0.896 | 108.19 | 30.00 | 3 | 0.0188 | 291 | 0.0006 | 29.72 | 7.605 | 0.2191 | 329218.0 | 199000000 | 124000000000 | 78600000000000 | 0.3988 | 0.2308 | 0.0014 | 0.0000 | 0.0019 | 0.0001 | 0.0040 | 0.0004 | 0.0105 | 0.0011 | 0.0269 | 0.0087 | 0.0473 | 0.0169 | 0.0485 | 0.0102 | 0.0672 | 0.0157 | 0.7922 | 0.9469 | 0.0001 | 0.0000 | 0.0002 | 0.0000 | 0.0005 | 0.0001 | 0.0023 | 0.0010 | 0.0107 | 0.0080 | 0.0188 | 0.0166 | 0.0160 | 0.0091 | 0.0204 | 0.0143 | 0.9310 | 0.9510 | 0.0029 | 0.0000 | 0.0095 | 0.0179 | 0.0147 | 0.0536 | 0.0297 | 0.1607 | 0.0612 | 0.1250 | 0.0718 | 0.1071 | 0.0872 | 0.2500 | 0.1213 | 0.1071 | 0.6015 | 0.1786 | 0.0008 | 0.0010 | 0.0032 | 0.0069 | 0.0226 | 0.0401 | 0.0411 | 0.0534 | 0.8309 | 7 | 9 | 10 | 11 | 12 | 15 | 40 | 206 | 467 | 0.3132 | 20.18 | 3.462 | 0.7115 | 59247.2 | 38200000 | 27600000000 | 21600000000000 | 0.5023 | 0.1444 | 0.0436 | 0.0036 | 0.1336 | 0.0128 | 0.2377 | 0.1026 | 0.1744 | 0.1354 | 0.1547 | 0.1810 | 0.1069 | 0.1882 | 0.0675 | 0.1055 | 0.0520 | 0.1119 | 0.0295 | 0.1589 | 0.0000 | 0.0003 | 0.0003 | 0.0004 | 0.0010 | 0.0004 | 0.0058 | 0.0038 | 0.0203 | 0.0189 | 0.0418 | 0.0353 | 0.0301 | 0.0220 | 0.0517 | 0.0418 | 0.8491 | 0.8771 | 0.0000 | 0.0000 | 0.0006 | 0.0005 | 0.0003 | 0.0005 | 0.0058 | 0.0079 | 0.0263 | 0.0302 | 0.0558 | 0.0631 | 0.0452 | 0.0492 | 0.0622 | 0.0705 | 0.8037 | 0.7782 | 0.0000 | 0.0000 | 0.0006 | 0.0049 | 0.0263 | 0.0486 | 0.0405 | 0.0571 | 0.8221 |
| BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 692 | 185 | | 19415 | 44441 | 368.7 | 56.02 | 244.04 | 276.54 | 299 | 324 | 341 | 357 | 370 | 384 | 398 | 414 | 438 | 0.0403 | 1792 | 0.714 | 124.33 | 24.70 | 1 | 0.0157 | 305 | 0.0014 | 22.18 | 6.923 | 0.2357 | 139081.0 | 53500000 | 21000000000 | 8390000000000 | 0.4311 | 0.2269 | 0.0001 | 0.0000 | 0.0008 | 0.0001 | 0.0028 | 0.0001 | 0.0066 | 0.0002 | 0.0259 | 0.0087 | 0.0530 | 0.0182 | 0.0576 | 0.0109 | 0.0865 | 0.0176 | 0.7667 | 0.9443 | 0.0001 | 0.0000 | 0.0004 | 0.0001 | 0.0011 | 0.0001 | 0.0033 | 0.0002 | 0.0141 | 0.0084 | 0.0282 | 0.0172 | 0.0273 | 0.0090 | 0.0375 | 0.0134 | 0.8880 | 0.9517 | 0.0119 | 0.0000 | 0.0209 | 0.0000 | 0.0346 | 0.0000 | 0.0930 | 0.0000 | 0.1169 | 0.0000 | 0.1574 | 0.0000 | 0.1199 | 0.0000 | 0.1306 | 0.0000 | 0.3148 | 0.0000 | 0.0012 | 0.0035 | 0.0100 | 0.0254 | 0.0509 | 0.0848 | 0.0988 | 0.1192 | 0.6061 | 17 | 22 | 30 | 54 | 118 | 220 | 341 | 473 | 647 | 0.0281 | 44.65 | 6.124 | 0.4266 | 136024.0 | 100000000 | 87800000000 | 88300000000000 | 0.4534 | 0.1804 | 0.0700 | 0.0020 | 0.2411 | 0.0134 | 0.3304 | 0.1499 | 0.1469 | 0.1951 | 0.0898 | 0.2149 | 0.0610 | 0.1886 | 0.0354 | 0.0976 | 0.0173 | 0.0724 | 0.0080 | 0.0662 | 0.0003 | 0.0002 | 0.0010 | 0.0004 | 0.0018 | 0.0013 | 0.0092 | 0.0076 | 0.0506 | 0.0416 | 0.1014 | 0.0881 | 0.0667 | 0.0543 | 0.0944 | 0.0803 | 0.6746 | 0.7262 | 0.0007 | 0.0004 | 0.0014 | 0.0017 | 0.0031 | 0.0043 | 0.0147 | 0.0194 | 0.0670 | 0.0789 | 0.1259 | 0.1392 | 0.0883 | 0.0943 | 0.1136 | 0.1275 | 0.5852 | 0.5343 | 0.0001 | 0.0007 | 0.0030 | 0.0105 | 0.0587 | 0.1131 | 0.0775 | 0.1049 | 0.6315 |
| BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 199 | 260 | | 10686 | 24087 | 343.1 | 42.34 | 218.62 | 243.80 | 294 | 309 | 319 | 329 | 339 | 349 | 361 | 376 | 398 | 0.0560 | 1348 | 1.108 | 80.65 | 27.02 | 2 | 0.0188 | 201 | 0.0020 | 20.94 | 6.553 | 0.2495 | 119532.0 | 42300000 | 15200000000 | 5550000000000 | 0.4430 | 0.2105 | 0.0001 | 0.0000 | 0.0002 | 0.0000 | 0.0012 | 0.0000 | 0.0032 | 0.0005 | 0.0194 | 0.0089 | 0.0355 | 0.0176 | 0.0461 | 0.0113 | 0.0755 | 0.0211 | 0.8188 | 0.9407 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0001 | 0.0000 | 0.0015 | 0.0000 | 0.0114 | 0.0086 | 0.0212 | 0.0159 | 0.0232 | 0.0077 | 0.0352 | 0.0146 | 0.9074 | 0.9532 | 0.0199 | 0.0000 | 0.0385 | 0.0000 | 0.0442 | 0.0000 | 0.0855 | 0.0000 | 0.0954 | 0.0000 | 0.1311 | 0.0000 | 0.1197 | 0.0000 | 0.1211 | 0.0000 | 0.3447 | 0.0000 | 0.0047 | 0.0098 | 0.0155 | 0.0422 | 0.0674 | 0.0986 | 0.1131 | 0.1277 | 0.5211 | 18 | 23 | 29 | 46 | 110 | 198 | 297 | 422 | 589 | 0.0307 | 46.12 | 5.951 | 0.4302 | 107227.0 | 68300000 | 50200000000 | 40800000000000 | 0.5298 | 0.1259 | 0.0245 | 0.0018 | 0.1127 | 0.0149 | 0.2277 | 0.0610 | 0.1750 | 0.0972 | 0.1550 | 0.1809 | 0.1245 | 0.2068 | 0.0732 | 0.1277 | 0.0609 | 0.1204 | 0.0464 | 0.1894 | 0.0000 | 0.0000 | 0.0005 | 0.0002 | 0.0017 | 0.0016 | 0.0077 | 0.0073 | 0.0415 | 0.0338 | 0.0707 | 0.0588 | 0.0495 | 0.0417 | 0.0772 | 0.0625 | 0.7513 | 0.7941 | 0.0004 | 0.0004 | 0.0010 | 0.0016 | 0.0029 | 0.0041 | 0.0139 | 0.0205 | 0.0578 | 0.0653 | 0.0903 | 0.1105 | 0.0763 | 0.0890 | 0.1087 | 0.1110 | 0.6487 | 0.5975 | 0.0001 | 0.0011 | 0.0034 | 0.0105 | 0.0471 | 0.0826 | 0.0615 | 0.0887 | 0.7050 |
| MDA-MB-231 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 673 | 661 | | 8356 | 21692 | 629.4 | 88.97 | 157.77 | 200.04 | 505 | 558 | 588 | 612 | 637 | 660 | 678 | 703 | 736 | 0.0423 | 917 | 1.088 | 108.30 | 37.05 | 1 | 0.0333 | 278 | 0.0009 | 30.54 | 7.337 | 0.2196 | 404042.0 | 264000000 | 175000000000 | 118000000000000 | 0.4222 | 0.2219 | 0.0003 | 0.0000 | 0.0004 | 0.0000 | 0.0007 | 0.0000 | 0.0036 | 0.0002 | 0.0168 | 0.0091 | 0.0339 | 0.0170 | 0.0309 | 0.0087 | 0.0431 | 0.0141 | 0.8703 | 0.9508 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0017 | 0.0002 | 0.0097 | 0.0091 | 0.0211 | 0.0170 | 0.0174 | 0.0087 | 0.0212 | 0.0141 | 0.9286 | 0.9508 | 0.0052 | 0.0000 | 0.0087 | 0.0000 | 0.0280 | 0.0000 | 0.0332 | 0.0000 | 0.0769 | 0.0000 | 0.1206 | 0.0000 | 0.0962 | 0.0000 | 0.1521 | 0.0000 | 0.4790 | 0.0000 | 0.0011 | 0.0031 | 0.0058 | 0.0105 | 0.0285 | 0.0524 | 0.0515 | 0.0731 | 0.7740 | 10 | 13 | 19 | 33 | 63 | 113 | 189 | 289 | 461 | 0.0633 | 29.43 | 5.277 | 0.5302 | 64906.9 | 36700000 | 24600000000 | 18400000000000 | 0.4278 | 0.2001 | 0.0270 | 0.0020 | 0.1224 | 0.0151 | 0.2282 | 0.0660 | 0.1787 | 0.1115 | 0.1483 | 0.1596 | 0.1201 | 0.2156 | 0.0684 | 0.1388 | 0.0615 | 0.1073 | 0.0454 | 0.1841 | 0.0001 | 0.0003 | 0.0002 | 0.0008 | 0.0015 | 0.0014 | 0.0077 | 0.0098 | 0.0437 | 0.0330 | 0.0678 | 0.0540 | 0.0479 | 0.0450 | 0.0793 | 0.0589 | 0.7519 | 0.7967 | 0.0005 | 0.0000 | 0.0015 | 0.0012 | 0.0026 | 0.0031 | 0.0122 | 0.0151 | 0.0611 | 0.0727 | 0.0953 | 0.1124 | 0.0662 | 0.0769 | 0.1035 | 0.1141 | 0.6570 | 0.6045 | 0.0001 | 0.0010 | 0.0024 | 0.0121 | 0.0486 | 0.0835 | 0.0554 | 0.0881 | 0.7087 |
| MCF7 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 828 | 486 | | 14994 | 31048 | 470.7 | 84.93 | 145.23 | 202.56 | 364 | 398 | 424 | 447 | 469 | 490 | 513 | 542 | 583 | 0.0407 | 1265 | 1.143 | 89.20 | 33.84 | 2 | 0.0156 | 234 | 0.0008 | 39.09 | 7.354 | 0.1815 | 228773.0 | 115000000 | 59000000000 | 31200000000000 | 0.4389 | 0.2085 | 0.0001 | 0.0000 | 0.0001 | 0.0000 | 0.0020 | 0.0001 | 0.0111 | 0.0005 | 0.0411 | 0.0092 | 0.0890 | 0.0204 | 0.0990 | 0.0211 | 0.1268 | 0.0342 | 0.6308 | 0.9146 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0008 | 0.0001 | 0.0049 | 0.0001 | 0.0183 | 0.0077 | 0.0417 | 0.0152 | 0.0417 | 0.0114 | 0.0544 | 0.0195 | 0.8381 | 0.9459 | 0.0048 | 0.0278 | 0.0077 | 0.0556 | 0.0191 | 0.1065 | 0.0689 | 0.1991 | 0.1411 | 0.2083 | 0.1689 | 0.1435 | 0.1325 | 0.0694 | 0.1536 | 0.1019 | 0.3033 | 0.0880 | 0.0004 | 0.0009 | 0.0068 | 0.0261 | 0.0682 | 0.1054 | 0.0961 | 0.1216 | 0.5745 | 6 | 8 | 10 | 13 | 30 | 83 | 171 | 296 | 457 | 0.1239 | 27.73 | 4.902 | 0.5414 | 62118.6 | 35000000 | 22900000000 | 16700000000000 | 0.4409 | 0.1994 | 0.0472 | 0.0018 | 0.1760 | 0.0086 | 0.2720 | 0.1069 | 0.1840 | 0.1494 | 0.1220 | 0.1901 | 0.0838 | 0.2070 | 0.0520 | 0.1123 | 0.0355 | 0.0968 | 0.0276 | 0.1271 | 0.0004 | 0.0000 | 0.0002 | 0.0003 | 0.0004 | 0.0005 | 0.0104 | 0.0070 | 0.0419 | 0.0383 | 0.0677 | 0.0587 | 0.0504 | 0.0418 | 0.0695 | 0.0619 | 0.7590 | 0.7915 | 0.0002 | 0.0002 | 0.0013 | 0.0006 | 0.0008 | 0.0007 | 0.0105 | 0.0168 | 0.0580 | 0.0609 | 0.0871 | 0.0932 | 0.0560 | 0.0646 | 0.0902 | 0.0922 | 0.6960 | 0.6707 | 0.0000 | 0.0003 | 0.0015 | 0.0114 | 0.0475 | 0.0781 | 0.0516 | 0.0805 | 0.7292 |
| BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 343 | 266 | | 9188 | 10970 | 380.5 | 50.11 | 368.80 | 331.03 | 317 | 338 | 353 | 366 | 379 | 392 | 407 | 423 | 446 | 0.0837 | 918 | 1.098 | 128.97 | 29.02 | 1 | 0.0293 | 269 | 0.0014 | 32.93 | 6.904 | 0.2140 | 147263.0 | 58000000 | 23200000000 | 9410000000000 | 0.4808 | 0.1754 | 0.0001 | 0.0000 | 0.0001 | 0.0000 | 0.0005 | 0.0000 | 0.0047 | 0.0002 | 0.0250 | 0.0095 | 0.0514 | 0.0210 | 0.0529 | 0.0104 | 0.0987 | 0.0165 | 0.7665 | 0.9424 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0001 | 0.0000 | 0.0012 | 0.0001 | 0.0138 | 0.0095 | 0.0278 | 0.0207 | 0.0261 | 0.0093 | 0.0415 | 0.0143 | 0.8895 | 0.9462 | 0.0218 | 0.0000 | 0.0328 | 0.0000 | 0.0593 | 0.0000 | 0.0874 | 0.0000 | 0.1732 | 0.0000 | 0.1841 | 0.0000 | 0.1435 | 0.0000 | 0.1388 | 0.0000 | 0.1591 | 0.0000 | 0.0011 | 0.0040 | 0.0097 | 0.0303 | 0.0725 | 0.1067 | 0.1129 | 0.1309 | 0.5320 | 26 | 44 | 103 | 182 | 274 | 391 | 529 | 679 | 850 | 0.0115 | 87.23 | 6.899 | 0.3039 | 245585.0 | 203000000 | 190000000000 | 195000000000000 | 0.5450 | 0.1332 | 0.0240 | 0.0019 | 0.1159 | 0.0052 | 0.2589 | 0.0480 | 0.1785 | 0.1152 | 0.1414 | 0.1989 | 0.1291 | 0.2063 | 0.0765 | 0.1279 | 0.0433 | 0.1290 | 0.0325 | 0.1677 | 0.0004 | 0.0003 | 0.0015 | 0.0005 | 0.0044 | 0.0031 | 0.0158 | 0.0085 | 0.0472 | 0.0440 | 0.0846 | 0.0769 | 0.0584 | 0.0516 | 0.0824 | 0.0766 | 0.7053 | 0.7384 | 0.0003 | 0.0009 | 0.0025 | 0.0032 | 0.0058 | 0.0059 | 0.0156 | 0.0215 | 0.0666 | 0.0792 | 0.1115 | 0.1340 | 0.0860 | 0.1022 | 0.1267 | 0.1240 | 0.5849 | 0.5290 | 0.0000 | 0.0026 | 0.0050 | 0.0109 | 0.0579 | 0.0934 | 0.0690 | 0.0986 | 0.6626 |
| BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1060 | 312 | | 8531 | 15239 | 406.2 | 51.13 | 226.15 | 245.25 | 342 | 364 | 380 | 392 | 404 | 416 | 431 | 449 | 474 | 0.0668 | 1018 | 0.868 | 57.87 | 17.89 | 1 | 0.0178 | 152 | 0.0013 | 38.37 | 6.954 | 0.1978 | 167626.0 | 70200000 | 29900000000 | 12900000000000 | 0.4561 | 0.1965 | 0.0000 | 0.0000 | 0.0001 | 0.0000 | 0.0013 | 0.0000 | 0.0042 | 0.0000 | 0.0191 | 0.0097 | 0.0469 | 0.0162 | 0.0566 | 0.0088 | 0.0892 | 0.0171 | 0.7825 | 0.9482 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0001 | 0.0000 | 0.0011 | 0.0000 | 0.0126 | 0.0097 | 0.0255 | 0.0162 | 0.0268 | 0.0088 | 0.0439 | 0.0152 | 0.8900 | 0.9501 | 0.0146 | 1.0000 | 0.0419 | 0.0000 | 0.0419 | 0.0000 | 0.1129 | 0.0000 | 0.1548 | 0.0000 | 0.1876 | 0.0000 | 0.1220 | 0.0000 | 0.1275 | 0.0000 | 0.1967 | 0.0000 | 0.0026 | 0.0043 | 0.0115 | 0.0412 | 0.0740 | 0.1178 | 0.1135 | 0.1283 | 0.5068 | 15 | 19 | 31 | 68 | 137 | 220 | 311 | 421 | 569 | 0.0214 | 62.72 | 6.209 | 0.3748 | 111286.0 | 74000000 | 60400000000 | 58100000000000 | 0.5099 | 0.1391 | 0.0526 | 0.0022 | 0.1940 | 0.0114 | 0.2544 | 0.1134 | 0.1674 | 0.1438 | 0.1298 | 0.1878 | 0.1032 | 0.1837 | 0.0545 | 0.1188 | 0.0292 | 0.1096 | 0.0149 | 0.1292 | 0.0000 | 0.0001 | 0.0001 | 0.0004 | 0.0007 | 0.0003 | 0.0079 | 0.0047 | 0.0500 | 0.0399 | 0.0844 | 0.0694 | 0.0697 | 0.0522 | 0.1028 | 0.0844 | 0.6841 | 0.7486 | 0.0000 | 0.0004 | 0.0002 | 0.0009 | 0.0027 | 0.0049 | 0.0148 | 0.0281 | 0.0769 | 0.0926 | 0.1317 | 0.1530 | 0.1039 | 0.1070 | 0.1377 | 0.1459 | 0.5322 | 0.4672 | 0.0000 | 0.0000 | 0.0020 | 0.0090 | 0.0602 | 0.1073 | 0.0860 | 0.1254 | 0.6102 |
| BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 489 | 816 | | 9613 | 19666 | 390.1 | 60.27 | 175.40 | 251.54 | 316 | 341 | 358 | 372 | 386 | 400 | 417 | 439 | 471 | 0.0499 | 981 | 1.140 | 113.53 | 39.96 | 1 | 0.0287 | 276 | 0.0011 | 38.49 | 7.151 | 0.1882 | 155802.0 | 63700000 | 26600000000 | 11400000000000 | 0.4343 | 0.2166 | 0.0001 | 0.0000 | 0.0004 | 0.0000 | 0.0009 | 0.0000 | 0.0063 | 0.0003 | 0.0283 | 0.0097 | 0.0643 | 0.0203 | 0.0756 | 0.0131 | 0.1055 | 0.0246 | 0.7186 | 0.9320 | 0.0000 | 0.0000 | 0.0001 | 0.0000 | 0.0003 | 0.0000 | 0.0028 | 0.0001 | 0.0131 | 0.0084 | 0.0304 | 0.0170 | 0.0306 | 0.0084 | 0.0456 | 0.0152 | 0.8770 | 0.9508 | 0.0087 | 0.0000 | 0.0135 | 0.0000 | 0.0279 | 0.0000 | 0.0983 | 0.0000 | 0.1387 | 0.0000 | 0.1513 | 0.0000 | 0.1416 | 0.0000 | 0.1262 | 0.0000 | 0.2938 | 0.0000 | 0.0011 | 0.0035 | 0.0104 | 0.0298 | 0.0782 | 0.1108 | 0.1017 | 0.1210 | 0.5436 | 14 | 16 | 20 | 33 | 69 | 120 | 189 | 295 | 474 | 0.0394 | 31.15 | 5.368 | 0.5068 | 94034.5 | 84100000 | 103000000000 | 154000000000000 | 0.3897 | 0.2589 | 0.0213 | 0.0011 | 0.1385 | 0.0082 | 0.2420 | 0.0616 | 0.1776 | 0.1065 | 0.1672 | 0.1616 | 0.1236 | 0.1947 | 0.0759 | 0.1312 | 0.0374 | 0.1260 | 0.0167 | 0.2092 | 0.0000 | 0.0000 | 0.0001 | 0.0005 | 0.0018 | 0.0009 | 0.0087 | 0.0075 | 0.0520 | 0.0374 | 0.0873 | 0.0660 | 0.0601 | 0.0490 | 0.0912 | 0.0703 | 0.6988 | 0.7683 | 0.0002 | 0.0002 | 0.0016 | 0.0006 | 0.0035 | 0.0034 | 0.0199 | 0.0226 | 0.0723 | 0.0866 | 0.1159 | 0.1289 | 0.0783 | 0.0860 | 0.1143 | 0.1210 | 0.5940 | 0.5507 | 0.0000 | 0.0008 | 0.0022 | 0.0144 | 0.0633 | 0.0998 | 0.0700 | 0.1025 | 0.6469 |
| MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 655 | 519 | | 12431 | 24620 | 390.0 | 70.08 | 73.02 | 145.52 | 287 | 322 | 350 | 376 | 398 | 418 | 437 | 454 | 476 | 0.0531 | 1307 | 0.717 | 116.71 | 35.11 | 3 | 0.0323 | 401 | 0.0014 | 13.24 | 6.814 | 0.3028 | 157023.0 | 65000000 | 27500000000 | 11900000000000 | 0.4378 | 0.1981 | 0.0007 | 0.0000 | 0.0029 | 0.0000 | 0.0055 | 0.0000 | 0.0115 | 0.0009 | 0.0276 | 0.0098 | 0.0447 | 0.0175 | 0.0492 | 0.0111 | 0.0732 | 0.0171 | 0.7847 | 0.9436 | 0.0001 | 0.0000 | 0.0009 | 0.0000 | 0.0019 | 0.0000 | 0.0037 | 0.0009 | 0.0122 | 0.0098 | 0.0195 | 0.0175 | 0.0178 | 0.0105 | 0.0271 | 0.0152 | 0.9168 | 0.9461 | 0.0102 | 1.0000 | 0.0215 | 0.0000 | 0.0269 | 0.0000 | 0.0449 | 0.0000 | 0.0682 | 0.0000 | 0.0922 | 0.0000 | 0.0999 | 0.0000 | 0.1191 | 0.0000 | 0.5171 | 0.0000 | 0.0007 | 0.0036 | 0.0042 | 0.0104 | 0.0227 | 0.0348 | 0.0407 | 0.0547 | 0.8282 | 8 | 10 | 11 | 13 | 15 | 20 | 33 | 82 | 218 | 0.1379 | 2.58 | 2.741 | 0.6004 | 26508.4 | 16200000 | 12600000000 | 11400000000000 | 0.6289 | 0.0769 | 0.0413 | 0.0027 | 0.1013 | 0.0182 | 0.1888 | 0.0633 | 0.1750 | 0.0919 | 0.1721 | 0.1461 | 0.1327 | 0.1875 | 0.1013 | 0.1379 | 0.0560 | 0.1347 | 0.0315 | 0.2176 | 0.0002 | 0.0005 | 0.0007 | 0.0006 | 0.0016 | 0.0015 | 0.0123 | 0.0101 | 0.0446 | 0.0428 | 0.0768 | 0.0683 | 0.0519 | 0.0466 | 0.0718 | 0.0703 | 0.7402 | 0.7592 | 0.0004 | 0.0009 | 0.0008 | 0.0018 | 0.0023 | 0.0018 | 0.0159 | 0.0140 | 0.0529 | 0.0605 | 0.0898 | 0.0918 | 0.0567 | 0.0628 | 0.0814 | 0.0868 | 0.6997 | 0.6794 | 0.0004 | 0.0000 | 0.0015 | 0.0114 | 0.0529 | 0.0806 | 0.0550 | 0.0825 | 0.7157 |
| MDA-MB-231 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 937 | 792 | | 9123 | 21746 | 335.0 | 60.34 | 75.58 | 106.02 | 251 | 283 | 304 | 322 | 338 | 352 | 368 | 385 | 407 | 0.0469 | 1020 | 1.203 | 88.96 | 31.32 | 2 | 0.0240 | 219 | 0.0031 | 5.79 | 6.087 | 0.3990 | 115860.0 | 41200000 | 15100000000 | 5640000000000 | 0.3775 | 0.2592 | 0.0006 | 0.0000 | 0.0019 | 0.0001 | 0.0030 | 0.0007 | 0.0099 | 0.0012 | 0.0231 | 0.0099 | 0.0367 | 0.0248 | 0.0410 | 0.0160 | 0.0611 | 0.0234 | 0.8226 | 0.9239 | 0.0001 | 0.0000 | 0.0004 | 0.0000 | 0.0010 | 0.0003 | 0.0037 | 0.0008 | 0.0116 | 0.0086 | 0.0156 | 0.0195 | 0.0156 | 0.0089 | 0.0230 | 0.0132 | 0.9290 | 0.9487 | 0.0127 | 0.0397 | 0.0136 | 0.0397 | 0.0363 | 0.1429 | 0.0417 | 0.1190 | 0.0644 | 0.1587 | 0.0816 | 0.1905 | 0.0743 | 0.0635 | 0.0988 | 0.0952 | 0.5766 | 0.1508 | 0.0021 | 0.0040 | 0.0109 | 0.0129 | 0.0253 | 0.0322 | 0.0430 | 0.0670 | 0.8026 | 6 | 7 | 9 | 13 | 26 | 46 | 79 | 134 | 219 | 0.0597 | 7.19 | 4.039 | 0.5263 | 16952.4 | 5760000 | 2510000000 | 1300000000000 | 0.3182 | 0.3239 | 0.0564 | 0.0038 | 0.1472 | 0.0263 | 0.2620 | 0.0928 | 0.1675 | 0.1276 | 0.1368 | 0.1702 | 0.0969 | 0.1688 | 0.0595 | 0.1401 | 0.0485 | 0.1159 | 0.0252 | 0.1545 | 0.0001 | 0.0005 | 0.0012 | 0.0006 | 0.0032 | 0.0031 | 0.0151 | 0.0112 | 0.0474 | 0.0451 | 0.0827 | 0.0582 | 0.0582 | 0.0542 | 0.0838 | 0.0756 | 0.7083 | 0.7517 | 0.0012 | 0.0002 | 0.0012 | 0.0019 | 0.0027 | 0.0043 | 0.0211 | 0.0249 | 0.0642 | 0.0784 | 0.1127 | 0.1071 | 0.0701 | 0.0779 | 0.0991 | 0.1155 | 0.6278 | 0.5898 | 0.0006 | 0.0010 | 0.0024 | 0.0164 | 0.0621 | 0.0942 | 0.0691 | 0.0956 | 0.6587 | ||
| SK-BR-3 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 406 | 653 | | 9716 | 23603 | 431.9 | 88.96 | 349.44 | 405.84 | 326 | 380 | 406 | 425 | 442 | 459 | 475 | 495 | 525 | 0.0445 | 1051 | 1.155 | 114.98 | 44.01 | 1 | 0.0310 | 301 | 0.0009 | 57.02 | 7.395 | 0.1756 | 194415.0 | 90200000 | 42900000000 | 20900000000000 | 0.4256 | 0.2144 | 0.0000 | 0.0000 | 0.0001 | 0.0000 | 0.0024 | 0.0002 | 0.0073 | 0.0009 | 0.0306 | 0.0101 | 0.0644 | 0.0220 | 0.0617 | 0.0172 | 0.1018 | 0.0289 | 0.7315 | 0.9207 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0001 | 0.0000 | 0.0014 | 0.0003 | 0.0115 | 0.0083 | 0.0248 | 0.0165 | 0.0200 | 0.0081 | 0.0331 | 0.0149 | 0.9091 | 0.9519 | 0.0122 | 0.0252 | 0.0157 | 0.0692 | 0.0332 | 0.0503 | 0.0752 | 0.1195 | 0.1461 | 0.2201 | 0.1785 | 0.1698 | 0.1400 | 0.0943 | 0.1417 | 0.1321 | 0.2572 | 0.1195 | 0.0002 | 0.0018 | 0.0031 | 0.0201 | 0.0458 | 0.0885 | 0.0915 | 0.1196 | 0.6294 | 11 | 15 | 26 | 74 | 177 | 311 | 477 | 692 | 979 | 0.0386 | 101.07 | 6.457 | 0.3962 | 286810.0 | 301000000 | 364000000000 | 491000000000000 | 0.5288 | 0.1335 | 0.0292 | 0.0023 | 0.1390 | 0.0075 | 0.2010 | 0.0674 | 0.1542 | 0.1168 | 0.1584 | 0.1632 | 0.1246 | 0.1791 | 0.0806 | 0.1344 | 0.0556 | 0.1290 | 0.0574 | 0.2002 | 0.0001 | 0.0001 | 0.0006 | 0.0003 | 0.0019 | 0.0007 | 0.0085 | 0.0046 | 0.0443 | 0.0358 | 0.0839 | 0.0706 | 0.0599 | 0.0519 | 0.0888 | 0.0796 | 0.7120 | 0.7564 | 0.0001 | 0.0003 | 0.0008 | 0.0014 | 0.0045 | 0.0043 | 0.0123 | 0.0170 | 0.0555 | 0.0621 | 0.1009 | 0.1122 | 0.0725 | 0.0814 | 0.1086 | 0.1185 | 0.6449 | 0.6027 | 0.0005 | 0.0014 | 0.0034 | 0.0121 | 0.0467 | 0.0905 | 0.0701 | 0.0917 | 0.6837 |
| BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 465 | 643 | | 8720 | 12380 | 327.7 | 56.71 | 178.47 | 263.33 | 253 | 288 | 306 | 320 | 333 | 346 | 358 | 371 | 394 | 0.0826 | 1023 | 1.053 | 189.34 | 55.01 | 1 | 0.0515 | 449 | 0.0016 | 19.71 | 6.739 | 0.2552 | 110617.0 | 38300000 | 13500000000 | 4860000000000 | 0.4132 | 0.2316 | 0.0001 | 0.0000 | 0.0000 | 0.0001 | 0.0010 | 0.0001 | 0.0059 | 0.0010 | 0.0246 | 0.0101 | 0.0541 | 0.0199 | 0.0557 | 0.0130 | 0.0950 | 0.0226 | 0.7636 | 0.9332 | 0.0000 | 0.0000 | 0.0000 | 0.0001 | 0.0000 | 0.0001 | 0.0030 | 0.0009 | 0.0126 | 0.0096 | 0.0228 | 0.0178 | 0.0228 | 0.0096 | 0.0370 | 0.0162 | 0.9017 | 0.9456 | 0.0114 | 0.0000 | 0.0227 | 0.0000 | 0.0272 | 0.0000 | 0.0681 | 0.0000 | 0.0988 | 0.0000 | 0.1703 | 0.0000 | 0.1067 | 0.0000 | 0.1226 | 0.0000 | 0.3723 | 0.0000 | 0.0008 | 0.0019 | 0.0071 | 0.0173 | 0.0483 | 0.0854 | 0.0861 | 0.1201 | 0.6330 | 18 | 25 | 36 | 52 | 72 | 98 | 148 | 262 | 503 | 0.0250 | 35.86 | 5.284 | 0.5431 | 101188.0 | 92200000 | 104000000000 | 133000000000000 | 0.5504 | 0.1103 | 0.0118 | 0.0028 | 0.0634 | 0.0052 | 0.1160 | 0.0282 | 0.1461 | 0.0612 | 0.1912 | 0.1266 | 0.1751 | 0.1507 | 0.1224 | 0.1351 | 0.0988 | 0.1573 | 0.0752 | 0.3329 | 0.0005 | 0.0002 | 0.0003 | 0.0011 | 0.0024 | 0.0023 | 0.0079 | 0.0094 | 0.0482 | 0.0428 | 0.0854 | 0.0656 | 0.0514 | 0.0563 | 0.0801 | 0.0808 | 0.7238 | 0.7415 | 0.0000 | 0.0000 | 0.0021 | 0.0008 | 0.0042 | 0.0035 | 0.0101 | 0.0097 | 0.0538 | 0.0635 | 0.0894 | 0.0884 | 0.0594 | 0.0666 | 0.0876 | 0.0970 | 0.6934 | 0.6706 | 0.0000 | 0.0003 | 0.0031 | 0.0089 | 0.0520 | 0.0851 | 0.0560 | 0.0875 | 0.7072 |
| BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 713 | 522 | | 16894 | 27359 | 277.6 | 52.05 | 216.35 | 215.57 | 208 | 237 | 256 | 269 | 281 | 294 | 306 | 320 | 341 | 0.0538 | 1471 | 1.091 | 103.16 | 31.06 | 2 | 0.0146 | 247 | 0.0019 | 13.94 | 6.613 | 0.2949 | 79797.3 | 23600000 | 7150000000 | 2220000000000 | 0.4393 | 0.2062 | 0.0005 | 0.0001 | 0.0011 | 0.0000 | 0.0033 | 0.0002 | 0.0092 | 0.0012 | 0.0381 | 0.0103 | 0.0669 | 0.0200 | 0.0670 | 0.0172 | 0.0957 | 0.0278 | 0.7182 | 0.9233 | 0.0001 | 0.0001 | 0.0003 | 0.0000 | 0.0008 | 0.0001 | 0.0036 | 0.0009 | 0.0175 | 0.0093 | 0.0294 | 0.0173 | 0.0273 | 0.0120 | 0.0360 | 0.0204 | 0.8849 | 0.9400 | 0.0059 | 0.0000 | 0.0174 | 0.0000 | 0.0329 | 0.0000 | 0.0567 | 0.0000 | 0.1025 | 0.0000 | 0.1459 | 0.0000 | 0.1189 | 0.0000 | 0.1432 | 0.0000 | 0.3765 | 0.0000 | 0.0017 | 0.0028 | 0.0050 | 0.0176 | 0.0419 | 0.0771 | 0.0726 | 0.0997 | 0.6818 | 21 | 32 | 52 | 93 | 142 | 205 | 283 | 380 | 530 | 0.0112 | 32.03 | 6.315 | 0.3897 | 93278.7 | 53900000 | 36900000000 | 28400000000000 | 0.5194 | 0.1468 | 0.0368 | 0.0022 | 0.1715 | 0.0112 | 0.2748 | 0.0782 | 0.1614 | 0.1448 | 0.1334 | 0.1933 | 0.0945 | 0.1853 | 0.0577 | 0.1275 | 0.0408 | 0.1189 | 0.0291 | 0.1384 | 0.0004 | 0.0005 | 0.0011 | 0.0010 | 0.0036 | 0.0028 | 0.0148 | 0.0107 | 0.0581 | 0.0512 | 0.1064 | 0.0873 | 0.0753 | 0.0672 | 0.1096 | 0.0986 | 0.6307 | 0.6805 | 0.0004 | 0.0009 | 0.0014 | 0.0032 | 0.0066 | 0.0087 | 0.0278 | 0.0330 | 0.0781 | 0.0932 | 0.1289 | 0.1454 | 0.1017 | 0.1011 | 0.1260 | 0.1267 | 0.5291 | 0.4877 | 0.0007 | 0.0016 | 0.0048 | 0.0183 | 0.0725 | 0.1147 | 0.0880 | 0.1182 | 0.5812 |
| MDA-MB-231 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 919 | 347 | | 5602 | 6122 | 469.4 | 79.21 | 27.49 | 47.62 | 357 | 396 | 427 | 455 | 479 | 496 | 513 | 531 | 559 | 0.1042 | 638 | 0.998 | 133.18 | 37.86 | 1 | 0.0605 | 339 | 0.0017 | 16.11 | 6.642 | 0.3084 | 226643.0 | 112000000 | 57000000000 | 29500000000000 | 0.4201 | 0.2305 | 0.0005 | 0.0000 | 0.0014 | 0.0000 | 0.0033 | 0.0000 | 0.0068 | 0.0007 | 0.0224 | 0.0104 | 0.0352 | 0.0294 | 0.0373 | 0.0137 | 0.0623 | 0.0225 | 0.8308 | 0.9233 | 0.0002 | 0.0000 | 0.0010 | 0.0000 | 0.0025 | 0.0000 | 0.0042 | 0.0005 | 0.0136 | 0.0097 | 0.0247 | 0.0272 | 0.0207 | 0.0098 | 0.0262 | 0.0177 | 0.9067 | 0.9351 | 0.0187 | 0.0000 | 0.0093 | 0.0541 | 0.0093 | 0.0811 | 0.0318 | 0.1622 | 0.0486 | 0.1892 | 0.0542 | 0.1892 | 0.0710 | 0.0811 | 0.0841 | 0.1351 | 0.6729 | 0.1081 | 0.0000 | 0.0020 | 0.0049 | 0.0120 | 0.0273 | 0.0462 | 0.0524 | 0.0908 | 0.7645 | 8 | 10 | 12 | 14 | 15 | 17 | 20 | 29 | 50 | 0.3237 | 1.45 | 2.056 | 0.8309 | 3023.4 | 1020000 | 532000000 | 337000000000 | 0.5358 | 0.1270 | 0.0965 | 0.0392 | 0.0856 | 0.0530 | 0.0911 | 0.0723 | 0.1111 | 0.0933 | 0.1840 | 0.1154 | 0.1858 | 0.1198 | 0.1056 | 0.1375 | 0.1093 | 0.1452 | 0.0310 | 0.2242 | 0.0300 | 0.0239 | 0.0257 | 0.0316 | 0.0178 | 0.0421 | 0.0165 | 0.0541 | 0.0484 | 0.0733 | 0.0772 | 0.0824 | 0.0502 | 0.0798 | 0.0876 | 0.0900 | 0.6467 | 0.5229 | 0.0018 | 0.0011 | 0.0092 | 0.0063 | 0.0111 | 0.0138 | 0.0129 | 0.0180 | 0.0563 | 0.0624 | 0.0969 | 0.0963 | 0.0572 | 0.0709 | 0.0895 | 0.1270 | 0.6651 | 0.6042 | 0.0092 | 0.0077 | 0.0061 | 0.0146 | 0.0452 | 0.0958 | 0.0598 | 0.0782 | 0.6835 | ||
| BT-20 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 1060 | 148 | | 9173 | 22344 | 294.9 | 54.87 | 142.27 | 167.42 | 227 | 246 | 262 | 276 | 290 | 304 | 321 | 343 | 371 | 0.0689 | 1540 | 0.872 | 128.71 | 44.38 | 1 | 0.0395 | 362 | 0.0007 | 53.70 | 7.461 | 0.1589 | 89976.7 | 28400000 | 9240000000 | 3100000000000 | 0.4189 | 0.2273 | 0.0002 | 0.0000 | 0.0012 | 0.0000 | 0.0039 | 0.0000 | 0.0119 | 0.0010 | 0.0544 | 0.0105 | 0.1011 | 0.0239 | 0.1296 | 0.0218 | 0.1648 | 0.0345 | 0.5330 | 0.9084 | 0.0000 | 0.0000 | 0.0004 | 0.0000 | 0.0013 | 0.0000 | 0.0059 | 0.0002 | 0.0246 | 0.0088 | 0.0420 | 0.0180 | 0.0587 | 0.0104 | 0.0811 | 0.0154 | 0.7860 | 0.9472 | 0.0035 | 0.0359 | 0.0110 | 0.0256 | 0.0311 | 0.0769 | 0.0876 | 0.1487 | 0.1090 | 0.1436 | 0.1739 | 0.1641 | 0.1256 | 0.1128 | 0.1387 | 0.1231 | 0.3195 | 0.1692 | 0.0012 | 0.0047 | 0.0077 | 0.0323 | 0.0798 | 0.1131 | 0.0949 | 0.1254 | 0.5411 | 14 | 17 | 22 | 39 | 72 | 114 | 176 | 260 | 379 | 0.0282 | 29.29 | 5.688 | 0.4480 | 48267.7 | 23800000 | 15100000000 | 12000000000000 | 0.5526 | 0.1273 | 0.0495 | 0.0023 | 0.1676 | 0.0182 | 0.2382 | 0.0872 | 0.1820 | 0.1262 | 0.1201 | 0.1819 | 0.1042 | 0.1777 | 0.0735 | 0.1315 | 0.0360 | 0.1131 | 0.0288 | 0.1618 | 0.0010 | 0.0004 | 0.0013 | 0.0008 | 0.0025 | 0.0027 | 0.0122 | 0.0114 | 0.0574 | 0.0459 | 0.1001 | 0.0810 | 0.0689 | 0.0643 | 0.0971 | 0.0872 | 0.6595 | 0.7063 | 0.0003 | 0.0003 | 0.0007 | 0.0013 | 0.0044 | 0.0053 | 0.0173 | 0.0217 | 0.0820 | 0.0881 | 0.1194 | 0.1360 | 0.0834 | 0.0891 | 0.1164 | 0.1154 | 0.5761 | 0.5428 | 0.0005 | 0.0013 | 0.0029 | 0.0153 | 0.0705 | 0.1085 | 0.0767 | 0.1091 | 0.6152 |
| MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 318 | 624 | | 6835 | 14487 | 545.4 | 80.10 | 171.75 | 314.77 | 430 | 485 | 516 | 537 | 554 | 568 | 585 | 605 | 635 | 0.0583 | 845 | 0.559 | 146.51 | 30.07 | 3 | 0.0660 | 451 | 0.0011 | 31.34 | 7.160 | 0.2167 | 303826.0 | 173000000 | 99800000000 | 58700000000000 | 0.4423 | 0.2040 | 0.0002 | 0.0000 | 0.0000 | 0.0000 | 0.0012 | 0.0000 | 0.0046 | 0.0007 | 0.0219 | 0.0105 | 0.0376 | 0.0227 | 0.0393 | 0.0121 | 0.0589 | 0.0224 | 0.8363 | 0.9315 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0021 | 0.0006 | 0.0138 | 0.0100 | 0.0230 | 0.0208 | 0.0226 | 0.0098 | 0.0272 | 0.0183 | 0.9111 | 0.9405 | 0.0093 | 0.0000 | 0.0163 | 0.0000 | 0.0280 | 0.0000 | 0.0676 | 0.0000 | 0.1189 | 0.0000 | 0.1352 | 0.0000 | 0.1119 | 0.0000 | 0.1119 | 0.0000 | 0.4009 | 0.0000 | 0.0008 | 0.0005 | 0.0050 | 0.0188 | 0.0379 | 0.0636 | 0.0767 | 0.0981 | 0.6986 | 11 | 13 | 15 | 19 | 25 | 47 | 102 | 252 | 575 | 0.1437 | 10.43 | 3.781 | 0.6289 | 128574.0 | 142000000 | 187000000000 | 273000000000000 | 0.3937 | 0.2546 | 0.0244 | 0.0022 | 0.0822 | 0.0126 | 0.1735 | 0.0445 | 0.1903 | 0.0867 | 0.2116 | 0.1890 | 0.1248 | 0.1883 | 0.0868 | 0.1401 | 0.0715 | 0.1371 | 0.0350 | 0.1994 | 0.0000 | 0.0005 | 0.0010 | 0.0007 | 0.0036 | 0.0030 | 0.0067 | 0.0079 | 0.0359 | 0.0345 | 0.0508 | 0.0483 | 0.0398 | 0.0391 | 0.0646 | 0.0606 | 0.7976 | 0.8055 | 0.0009 | 0.0007 | 0.0009 | 0.0010 | 0.0028 | 0.0020 | 0.0080 | 0.0081 | 0.0423 | 0.0430 | 0.0537 | 0.0696 | 0.0515 | 0.0545 | 0.0771 | 0.0794 | 0.7628 | 0.7418 | 0.0006 | 0.0014 | 0.0023 | 0.0093 | 0.0369 | 0.0544 | 0.0417 | 0.0668 | 0.7866 |
| BT-20 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 472 | 365 | | 10152 | 16333 | 306.6 | 57.54 | 224.30 | 196.37 | 237 | 256 | 271 | 285 | 301 | 317 | 336 | 357 | 386 | 0.0678 | 1107 | 0.822 | 136.62 | 44.05 | 1 | 0.0396 | 402 | 0.0006 | 77.66 | 7.651 | 0.1416 | 97320.9 | 31900000 | 10800000000 | 3780000000000 | 0.4559 | 0.2016 | 0.0007 | 0.0000 | 0.0006 | 0.0000 | 0.0038 | 0.0001 | 0.0147 | 0.0006 | 0.0559 | 0.0105 | 0.1218 | 0.0272 | 0.1337 | 0.0260 | 0.1584 | 0.0428 | 0.5103 | 0.8928 | 0.0002 | 0.0000 | 0.0000 | 0.0000 | 0.0011 | 0.0000 | 0.0036 | 0.0001 | 0.0257 | 0.0079 | 0.0578 | 0.0184 | 0.0582 | 0.0109 | 0.0841 | 0.0197 | 0.7693 | 0.9430 | 0.0025 | 0.0159 | 0.0101 | 0.0518 | 0.0297 | 0.0876 | 0.0802 | 0.2072 | 0.1723 | 0.1952 | 0.1799 | 0.1474 | 0.1187 | 0.1036 | 0.1503 | 0.0558 | 0.2563 | 0.1355 | 0.0008 | 0.0025 | 0.0127 | 0.0317 | 0.0909 | 0.1254 | 0.1094 | 0.1379 | 0.4885 | 22 | 46 | 83 | 125 | 173 | 229 | 295 | 376 | 500 | 0.0068 | 69.26 | 6.886 | 0.2834 | 88869.9 | 46400000 | 29000000000 | 20500000000000 | 0.5451 | 0.1262 | 0.0275 | 0.0020 | 0.1405 | 0.0066 | 0.2540 | 0.0553 | 0.1753 | 0.1106 | 0.1531 | 0.1890 | 0.1086 | 0.2034 | 0.0715 | 0.1379 | 0.0376 | 0.1361 | 0.0319 | 0.1591 | 0.0004 | 0.0006 | 0.0004 | 0.0007 | 0.0035 | 0.0023 | 0.0163 | 0.0094 | 0.0680 | 0.0540 | 0.1119 | 0.0867 | 0.0864 | 0.0698 | 0.1192 | 0.1056 | 0.5940 | 0.6708 | 0.0002 | 0.0013 | 0.0020 | 0.0036 | 0.0087 | 0.0107 | 0.0296 | 0.0330 | 0.1018 | 0.1162 | 0.1498 | 0.1759 | 0.1073 | 0.1119 | 0.1433 | 0.1478 | 0.4572 | 0.3996 | 0.0004 | 0.0016 | 0.0045 | 0.0181 | 0.0879 | 0.1310 | 0.0994 | 0.1385 | 0.5186 |
| MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 349 | 807 | | 6538 | 12626 | 588.0 | 86.69 | 128.31 | 222.66 | 469 | 530 | 562 | 584 | 602 | 620 | 637 | 657 | 683 | 0.0673 | 850 | 0.775 | 146.56 | 30.15 | 1 | 0.0509 | 333 | 0.0010 | 44.42 | 7.238 | 0.1938 | 353259.0 | 216000000 | 134000000000 | 83900000000000 | 0.4229 | 0.2180 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0007 | 0.0000 | 0.0030 | 0.0002 | 0.0197 | 0.0106 | 0.0355 | 0.0173 | 0.0365 | 0.0112 | 0.0673 | 0.0176 | 0.8370 | 0.9433 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0015 | 0.0002 | 0.0129 | 0.0106 | 0.0221 | 0.0173 | 0.0201 | 0.0112 | 0.0312 | 0.0176 | 0.9121 | 0.9433 | 0.0276 | 0.0000 | 0.0379 | 0.0000 | 0.0379 | 0.0000 | 0.1241 | 0.0000 | 0.1310 | 0.0000 | 0.1586 | 0.0000 | 0.1241 | 0.0000 | 0.0931 | 0.0000 | 0.2655 | 0.0000 | 0.0011 | 0.0034 | 0.0053 | 0.0169 | 0.0344 | 0.0573 | 0.0655 | 0.0922 | 0.7238 | 11 | 13 | 16 | 21 | 29 | 46 | 87 | 188 | 404 | 0.1397 | 11.93 | 3.675 | 0.6149 | 66036.9 | 54600000 | 58200000000 | 74400000000000 | 0.4876 | 0.1751 | 0.0820 | 0.0077 | 0.2182 | 0.0463 | 0.2753 | 0.1683 | 0.1406 | 0.1143 | 0.1083 | 0.1550 | 0.0849 | 0.1907 | 0.0395 | 0.1066 | 0.0249 | 0.0863 | 0.0264 | 0.1248 | 0.0000 | 0.0005 | 0.0009 | 0.0010 | 0.0026 | 0.0022 | 0.0131 | 0.0124 | 0.0707 | 0.0604 | 0.0993 | 0.0897 | 0.0678 | 0.0592 | 0.1013 | 0.0905 | 0.6443 | 0.6841 | 0.0000 | 0.0004 | 0.0004 | 0.0004 | 0.0039 | 0.0019 | 0.0218 | 0.0250 | 0.0761 | 0.0832 | 0.1208 | 0.1271 | 0.0778 | 0.0847 | 0.1127 | 0.1144 | 0.5866 | 0.5630 | 0.0003 | 0.0003 | 0.0029 | 0.0147 | 0.0809 | 0.1055 | 0.0723 | 0.1125 | 0.6106 |
| MDA-MB-231 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 945 | 791 | | 7136 | 8653 | 396.4 | 68.86 | 331.09 | 487.17 | 292 | 338 | 365 | 386 | 406 | 423 | 439 | 454 | 478 | 0.0953 | 825 | 1.046 | 109.66 | 38.48 | 6 | 0.0419 | 299 | 0.0024 | 9.08 | 6.362 | 0.3660 | 161888.0 | 67800000 | 29000000000 | 12700000000000 | 0.4181 | 0.2153 | 0.0006 | 0.0000 | 0.0015 | 0.0000 | 0.0038 | 0.0000 | 0.0079 | 0.0011 | 0.0218 | 0.0106 | 0.0533 | 0.0271 | 0.0385 | 0.0132 | 0.0585 | 0.0186 | 0.8142 | 0.9294 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0005 | 0.0000 | 0.0025 | 0.0011 | 0.0113 | 0.0105 | 0.0289 | 0.0260 | 0.0141 | 0.0119 | 0.0204 | 0.0173 | 0.9222 | 0.9333 | 0.0066 | 0.0000 | 0.0066 | 0.0000 | 0.0263 | 0.0000 | 0.0447 | 0.0000 | 0.1092 | 0.0000 | 0.1184 | 0.0000 | 0.1158 | 0.0000 | 0.1382 | 0.0000 | 0.4342 | 0.0000 | 0.0005 | 0.0015 | 0.0051 | 0.0101 | 0.0281 | 0.0398 | 0.0367 | 0.0529 | 0.8252 | 10 | 12 | 15 | 26 | 85 | 211 | 381 | 631 | 998 | 0.1055 | 26.80 | 5.014 | 0.5502 | 346927.0 | 541000000 | 1110000000000 | 2.77E+15 | 0.4761 | 0.1685 | 0.0161 | 0.0031 | 0.0966 | 0.0086 | 0.1804 | 0.0350 | 0.1739 | 0.0871 | 0.1643 | 0.1540 | 0.1433 | 0.1882 | 0.0934 | 0.1407 | 0.0805 | 0.1198 | 0.0515 | 0.2636 | 0.0003 | 0.0008 | 0.0006 | 0.0014 | 0.0025 | 0.0017 | 0.0063 | 0.0068 | 0.0348 | 0.0256 | 0.0659 | 0.0501 | 0.0446 | 0.0400 | 0.0681 | 0.0535 | 0.7768 | 0.8202 | 0.0000 | 0.0004 | 0.0004 | 0.0018 | 0.0039 | 0.0049 | 0.0102 | 0.0123 | 0.0481 | 0.0511 | 0.0777 | 0.0886 | 0.0560 | 0.0675 | 0.0765 | 0.0825 | 0.7272 | 0.6909 | 0.0000 | 0.0004 | 0.0036 | 0.0093 | 0.0411 | 0.0750 | 0.0496 | 0.0650 | 0.7562 |