LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 5 of 15: Mean cell count and mean growth rate across biological replicate 2. - Dataset (ID:20241)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | WZ3105 | 3.33 | uM | LJP5 | 72 | hr | 1694 | 386 | 11155 | 0.0346 | -0.1382 |
| MCF 10A | XMD11-50 | 3.33 | uM | LJP6 | 72 | hr | 1694 | 5322 | 11155 | 0.4771 | 0.3835 |
| MCF 10A | Y39983 | 3.33 | uM | LJP6 | 72 | hr | 1694 | 8452 | 11155 | 0.7576 | 0.7142 |
| MCF 10A | YM 201636 | 3.33 | uM | LJP5 | 72 | hr | 1694 | 8260 | 11155 | 0.7404 | 0.6940 |
| MCF 10A | ZSTK474 | 3.33 | uM | LJP6 | 72 | hr | 1694 | 3867 | 11155 | 0.3466 | 0.2296 |
| MCF 10A | Afatinib | 10.0 | uM | LJP6 | 72 | hr | 1694 | 1764 | 11155 | 0.1581 | 0.0074 |
| MCF 10A | Sigma A6730 | 10.0 | uM | LJP5 | 72 | hr | 1694 | 6934 | 11155 | 0.6216 | 0.5539 |
| MCF 10A | Alvocidib | 10.0 | uM | LJP6 | 72 | hr | 1694 | 336 | 11155 | 0.0301 | -0.1436 |
| MCF 10A | AT-7519 | 10.0 | uM | LJP6 | 72 | hr | 1694 | 253 | 11155 | 0.0227 | -0.1523 |
| MCF 10A | AZD 5438 | 10.0 | uM | LJP6 | 72 | hr | 1694 | 574 | 11155 | 0.0515 | -0.1184 |
| MCF 10A | AZD-6482 | 10.0 | uM | LJP5 | 72 | hr | 1694 | 4286 | 11155 | 0.3843 | 0.2740 |
| MCF 10A | AZD7762 | 10.0 | uM | LJP6 | 72 | hr | 1694 | 838 | 11155 | 0.0752 | -0.0904 |
| MCF 10A | AZD8055 | 10.0 | uM | LJP6 | 72 | hr | 1694 | 2374 | 11155 | 0.2128 | 0.0718 |
| MCF 10A | AZD8330 | 10.0 | uM | LJP5 | 72 | hr | 1694 | 2835 | 11155 | 0.2542 | 0.1206 |
| MCF 10A | Barasertib | 10.0 | uM | LJP5 | 72 | hr | 1694 | 2049 | 11155 | 0.1837 | 0.0376 |
| MCF 10A | BI-2536 | 10.0 | uM | LJP6 | 72 | hr | 1694 | 1413 | 11155 | 0.1267 | -0.0297 |
| MCF 10A | BMS345541 | 10.0 | uM | LJP6 | 72 | hr | 1694 | 9042 | 11155 | 0.8105 | 0.7766 |
| MCF 10A | SNS-032 | 10.0 | uM | LJP6 | 72 | hr | 1694 | 366 | 11155 | 0.0328 | -0.1404 |
| MCF 10A | GDC-0980 | 10.0 | uM | LJP5 | 72 | hr | 1694 | 2118 | 11155 | 0.1899 | 0.0449 |
| MCF 10A | NVP-AEW541 | 10.0 | uM | LJP5 | 72 | hr | 1694 | 5107 | 11155 | 0.4578 | 0.3607 |
| MCF 10A | SB590885 | 10.0 | uM | LJP5 | 72 | hr | 1694 | 7930 | 11155 | 0.7109 | 0.6591 |
| MCF 10A | PIK-93 | 10.0 | uM | LJP5 | 72 | hr | 1694 | 5474 | 11155 | 0.4907 | 0.3995 |
| MCF 10A | KIN001-043 | 10.0 | uM | LJP6 | 72 | hr | 1694 | 5448 | 11155 | 0.4884 | 0.3967 |
| MCF 10A | Alpelisib | 10.0 | uM | LJP5 | 72 | hr | 1694 | 4789 | 11155 | 0.4294 | 0.3272 |
| MCF 10A | Luminespib | 10.0 | uM | LJP5 | 72 | hr | 1694 | 1314 | 11155 | 0.1178 | -0.0402 |