The following browser tool allows you to explore the variable importance in the projection (VIP) score of each PLSR model variable relative to cell viability across all time points studied. This data browser also allows you to visualize the relative importance of each variable in the context of the molecular pathways impinging upon drug-induced adaptive responses in these cell lines.
The graph on the left maps the VIP scores (as reported by Fallahi-Sichani et al.) for any chosen combination of cell line and timepoint onto a schematic diagram of processes (in italics) and factors involved in immediate-early signaling. (See Figures 2 and 4 of Fallahi-Sichani et al.).
The heatmap on the right gives a bird's-eye-view of the same data, which can be used as a guide to which cell-line/timepoint combinations to focus on.
The colorbar at the bottom left of the page shows the mapping from colors to VIP scores. A striped background (on RPPA measurements in the graph or on heatmap cells) indicates a "not available" status.