GM6001 - Small Molecule (ID:10509-101)

HMS LINCS ID: 10509-101
Name: GM6001
Alternative Names: Ilomastat; Galardin; GM-6001
LINCS ID:
PubChem CID: 132519
ChEBI ID:
ChEMBL ID:
Molecular Mass: 388.21
InChi: InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1
InChi Key: NITYDPDXAAFEIT-DYVFJYSZSA-N
SMILES: CC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)NC
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-05-06

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
ADAM12, ADAM17, ADAM9, MMP1, MMP12, MMP13, MMP14, MMP15, MMP16, MMP17, MMP2, MMP26, MMP3, MMP7, MMP8, MMP9
2
(equivalent to 100 nM ≤ Kd < 1µM)
ADAM10

Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20268
Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates.
Analysis
20269
Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics.
Analysis

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10509-101-1 Enzo Life Sciences