Disulfiram - Small Molecule (ID:10507-999)

HMS LINCS ID: 10507-999
Name: Disulfiram
Alternative Names: Tetraethylthiuram disulfide; TETD
LINCS ID:
PubChem CID: 3117
ChEBI ID:
ChEMBL ID:
Molecular Mass: 296.05
InChi: InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
InChi Key: AUZONCFQVSMFAP-UHFFFAOYSA-N
SMILES: CCN(CC)C(=S)SSC(=S)N(CC)CC
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-05-06

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
2
(equivalent to 100 nM ≤ Kd < 1µM)
ALDH1A1, ALDH1A2, ALDH1B1, ALDH2, ALDH3B1, ALDH3B2
3
(equivalent to 1µM ≤ Kd < 10 µM)
Htr1b, MAPK3, MAPT, MGLL
10
(confirmed non-binding)
(Click to show)

Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20268
Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates.
Analysis
20269
Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics.
Analysis
20270
Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen.
Analysis

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10507-999-1