Taselisib - Small Molecule (ID:10445-101)

HMS LINCS ID: 10445-101
Name: Taselisib
Alternative Names: GDC-0032; RG-7604
LINCS ID: LSM-45140
PubChem CID: 51001932
ChEBI ID:
ChEMBL ID:
Molecular Mass: 460.23
InChi: InChI=1S/C24H28N8O2/c1-14(2)32-22(27-15(3)29-32)19-13-30-8-9-34-20-10-16(6-7-18(20)21(30)28-19)17-11-26-31(12-17)24(4,5)23(25)33/h6-7,10-14H,8-9H2,1-5H3,(H2,25,33)
InChi Key: BEUQXVWXFDOSAQ-UHFFFAOYSA-N
SMILES: CC1=NN(C(=N1)C2=CN3CCOC4=C(C3=N2)C=CC(=C4)C5=CN(N=C5)C(C)(C)C(=O)N)C(C)C
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2018-03-30

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
PIK3CA, PIK3CB, PIK3CD, PIK3CG
2
(equivalent to 100 nM ≤ Kd < 1µM)
PIK3C2B, PIK3C3
3
(equivalent to 1µM ≤ Kd < 10 µM)
MTOR, PRKDC
10
(confirmed non-binding)
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Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20264
Taselisib KINOMEscan
KINOMEscan
20343
Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values
Microscopy/Imaging
20344
Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics
Analysis

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10445-101-1 MedChem Express 10661