Axitinib - Small Molecule (ID:10443-101)

HMS LINCS ID: 10443-101
Name: Axitinib
Alternative Names: AG013736
LINCS ID:
PubChem CID: 6450551
ChEBI ID:
ChEMBL ID:
Molecular Mass: 386.12
InChi: InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)
InChi Key: RITAVMQDGBJQJZ-UHFFFAOYSA-N
SMILES: CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)C=CC4=CC=CC=N4
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
ABL1, ABL2, AIM1, AURKA, AURKB, AURKC, CSF1R, FLT1, FLT4, KDR, KIT, PDGFRA, PDGFRB, PLK4, TIE1
2
(equivalent to 100 nM ≤ Kd < 1µM)
AXL, CDKL2, DDR1, EPHB6, FGFR1, FGFR2, FGFR3, FLG, FLT3, LRRK2, MAP2K5, MAP3K19, MAP4K1, MAP4K2, MAP4K4, MAP4K5, MINK1, RET, SLK, STK16, TEK, TNIK, TNK1, ULK3
3
(equivalent to 1µM ≤ Kd < 10 µM)
AAK1, ACVR1, ACVR2B, AKT1, AKT2, ALK, ANKK1, BLK, BMP2K, BMPR1B, BRSK1, BTK, CAMK1, CAMK1D, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMKK1, CAMKK2, CDC42BPB, CDC7, CDK1, CDK16, CDK2, CDK5, CDK7, CDK8, CDK9, CHEK1, CHEK2, CHUK, CLK2, CLK4, CSK, CSNK1A1, CSNK1D, CSNK1G1, CSNK1G2, CSNK2A1, CSNK2A2, DAPK3, DCLK1, DDR2, DYRK1A, DYRK1B, DYRK3, EEF2K, EIF2AK2, EPHA2, ERBB2, ERBB4, FGR, FYN, GAK, GRK4, GRK5, GSK3A, GSK3B, HIPK2, HIPK4, HUNK, IGF1R, IKBKB, IKBKE, INSR, IRAK1, ITK, JAK2, JAK3, LCK, LIMK1, LTK, LYN, MAP2K1, MAP2K2, MAP3K12, MAP3K3, MAP3K4, MAP3K9, MAP4K3, MAPK1, MAPK10, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MAPKAPK2, MAPKAPK5, MARK2, MARK3, MELK, MERTK, MET, MKNK2, MST1, MST1R, MYLK2, MYLK3, MYO3A, NEK2, NEK4, NTRK1, NTRK2, NTRK3, NUAK2, PAK4, PASK, PDK1, PDPK1, PHKG2, PIM1, PIM2, PKN2, PRKAA1, PRKACA, PRKCD, PRKCG, PRKCQ, PRKCZ, PRKD3, PRKG1, PRKG2, PRKX, PTK2, PTK2B, RIOK1, RIOK3, RIPK1, RIPK2, RIPK4, ROCK1, ROCK2, ROS1, RPS6KA3, RPS6KB1, SIK1, SRC, SRPK1, SRPK3, STK10, STK3, STK4, TAOK1, TBK1, TESK1, TKT, TNK2, TSSK1B, TSSK2, TTK, TXK, TYK2, TYRO3, ULK2, YES1
10
(confirmed non-binding)
(Click to show)

Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10443-101-1 MedChem Express 06766