LY2090314 - Small Molecule (ID:10378-101)

HMS LINCS ID: 10378-101
Name: LY2090314
Alternative Names:
LINCS ID:
PubChem CID: 10029385
ChEBI ID:
ChEMBL ID:
Molecular Mass: 512.20
InChi: InChI=1S/C28H25FN6O3/c29-18-12-17-15-34(28(38)32-7-3-1-4-8-32)11-10-33-16-20(19(13-18)25(17)33)23-24(27(37)31-26(23)36)21-14-30-22-6-2-5-9-35(21)22/h2,5-6,9,12-14,16H,1,3-4,7-8,10-11,15H2,(H,31,36,37)
InChi Key: HRJWTAWVFDCTGO-UHFFFAOYSA-N
SMILES: C1CCN(CC1)C(=O)N2CCN3C=C(C4=CC(=CC(=C43)C2)F)C5=C(C(=O)NC5=O)C6=CN=C7N6C=CC=C7
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
GSK3A, GSK3B
2
(equivalent to 100 nM ≤ Kd < 1µM)
CDK1, CLK4, LCK, PIM1, PKN2, PRKAA1, PRKCB, STK17A
3
(equivalent to 1µM ≤ Kd < 10 µM)
AIM1, AKT2, AURKB, CAMK1, CDK2, CDK4, CDK5, CHEK1, CLK2, CSNK1A1, CSNK1D, CSNK1G1, CSNK1G2, CSNK1G3, CSNK2A1, DYRK1A, DYRK4, EPHA2, ERBB4, FGFR1, FLG, FLT4, HIPK2, HIPK4, INSR, IRAK1, MAP4K2, MAP4K5, MAPK1, MAPK8, MAPK9, MAPKAPK2, MARK2, MARK3, MINK1, NEK4, NTRK2, PAK4, PDK1, PDPK1, PHKG2, PIM3, PLK1, PLK3, PRKACA, PRKCD, PRKCG, PRKCI, PRKCZ, ROCK2, RPS6KA3, RPS6KB1, SLK, SRPK1, STK3, TAOK1, TGFBR2
10
(confirmed non-binding)
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Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10378-101-1 MedChem Express 10513