Filgotinib - Small Molecule (ID:10373-101)

HMS LINCS ID: 10373-101
Name: Filgotinib
Alternative Names: GLPG0634
LINCS ID:
PubChem CID: 49831257
ChEBI ID:
ChEMBL ID:
Molecular Mass: 425.15
InChi: InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)
InChi Key: RIJLVEAXPNLDTC-UHFFFAOYSA-N
SMILES: C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
Jak1, JAK1
2
(equivalent to 100 nM ≤ Kd < 1µM)
CSF1R, FLT3, FLT4, JAK3, TYK2
3
(equivalent to 1µM ≤ Kd < 10 µM)
JAK2
10
(confirmed non-binding)

Batch Information for HMSL10373-101-1:

HMS LINCS Batch ID: 10373-101-1
Provider: MedChem Express
Provider Batch ID: 11067
Salt: 101
Molecular Formula: C21H23N5O3S
Molecular Weight: 425.5
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2015-08-27
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10373-101-1:

Date HMS QC Outcome Comment Files
08/31/2015 PASS HMSL10373-101-1_LCMS.pdf