GNF-5837 - Small Molecule (ID:10365-101)

HMS LINCS ID: 10365-101
Name: GNF-5837
Alternative Names:
LINCS ID: LSM-44935
PubChem CID: 59397065
ChEBI ID:
ChEMBL ID:
Molecular Mass: 535.16
InChi: InChI=1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30,31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14,33-34H,1H3,(H,36,38)(H2,35,37,39)/b21-12-
InChi Key: YYDUWLSETXNJJT-MTJSOVHGSA-N
SMILES: CC1=C(C=C(C=C1)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)F)NC3=CC4=C(C=C3)/C(=C/C5=CC=CN5)/C(=O)N4
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2018-03-30

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
NTRK1, NTRK2
2
(equivalent to 100 nM ≤ Kd < 1µM)
Kit, NTRK3, Pdgfrb
3
(equivalent to 1µM ≤ Kd < 10 µM)
Alk, Bmx, Csf1r, Epha3, Ephb2, Fgfr3, Fgfr4, Fgr, Flt1, Flt3, Igf1r, Insr, KIT, Lyn, Mapk9, Met, Mst1r, Ret, Ros1, Src, Tie1, Zap70

Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10365-101-1 Selleck Chemicals S751901
10365-101-2 MedChem Express 10556