PKC412 - Small Molecule (ID:10220-101)

HMS LINCS ID: 10220-101
Name: PKC412
Alternative Names:
LINCS ID: LSM-1221
PubChem CID: 16760627
ChEBI ID:
ChEMBL ID: 338448
Molecular Mass: 570.23
InChi: InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)
InChi Key: BMGQWWVMWDBQGC-UHFFFAOYSA-N
SMILES: CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
AAK1, AIM1, AURKB, CAMK2A, CAMK2D, CAMKK2, EIF2AK4, FLT3, GRK1, GRK7, JAK2, JAK3, KIT, MAP3K11, MAP3K19, MAP3K9, MARK3, MST1, NUAK1, NUAK2, PKN1, PKN2, PLK4, PRKCB, PRKCG, PRKCZ, PRKG2, PRPF4, PRPF4B, RET, RIOK2, SIK3, SRPK1, SRPK3, STK4, SYK, TBK1, TNK1
2
(equivalent to 100 nM ≤ Kd < 1µM)
AKT1, AKT2, ALK, AURKA, AURKC, AXL, BLK, BMP2K, BRSK2, CAMK1D, CAMK2B, CAMK2G, CAMKK1, CLK1, CLK2, CLK4, CSF1R, CSNK2A1, DAPK2, DYRK1A, DYRK1B, FGR, FLT1, FLT4, GAK, GRK4, HCK, HIPK4, HUNK, IKBKE, IRAK3, JAK1, KDR, LCK, LRRK2, MAP3K10, MAP3K2, MAP3K3, MAP3K7, MAP4K3, MAP4K4, MARK1, MARK2, MARK4, MAST1, MELK, MET, MINK1, MKNK2, MYLK4, NTRK1, NTRK2, PAK3, PDGFRA, PDGFRB, PDK1, PDPK1, PF3D7_0217500, PHKG1, PIK3C2G, PIM1, PIM3, PIP4K2B, PIP5K1A, PRKAA1, PRKAA2, PRKACA, PRKACB, PRKCA, PRKCD, PRKCE, PRKCH, PRKCQ, PRKG1, PRKX, PTK2B, RIOK3, ROS1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, SIK1, SIK1B, SIK2, SLK, SRPK2, STK10, STK11, STK16, STK3, STK33, TNK2, TNKS2, TTK, TYK2, YES1
3
(equivalent to 1µM ≤ Kd < 10 µM)
ABL1, AKT3, BRSK1, C8orf44-SGK3, CAMK1, CAMK1G, CDK19, CHEK1, CHUK, CLK3, CSK, DAPK1, DAPK3, DDR1, DMPK, DSTYK, EGFR, EIF2AK2, EPHB6, ERBB4, ERN1, FER, FGFR1, FGFR2, FGFR3, FLG, FRK, FYN, GSK3A, GSK3B, HIPK2, HIPK3, ICK, IKBKB, LATS1, LATS2, LTK, LYN, MAP2K3, MAP2K4, MAP2K6, MAP3K13, MAP4K1, MAP4K2, MAP4K5, MAPK10, MAPK8, MAPK9, MERTK, MYLK, MYLK3, NTRK3, PAK1, PAK2, PHKG2, PIK3C2B, PIK3CA, PIM2, PKD2, PRKACG, PRKCI, PRKD2, PRKD3, RIOK1, ROCK1, ROCK2, RPS6KA6, RPS6KB1, SGK3, SRC, STK17A, STK17B, STK25, STK32A, TEK, TIE1, TNIK, TSSK1B, Tuba1a, ULK3, WEE1, ZAP70
10
(confirmed non-binding)
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Batch Information for HMSL10220-101-1:

HMS LINCS Batch ID: 10220-101-1
Provider: LC Laboratories
Provider Batch ID: BCP-102
Salt: 101
Molecular Formula: C35H30N4O4
Molecular Weight: 570.64
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2011-07-15
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10220-101-1:

Date HMS QC Outcome Comment Files
04/13/2015 PASS HMSL10220-101-1_LCMS.pdf