Go 6976 - Small Molecule (ID:10210-101)
| HMS LINCS ID: |
10210-101
|
| Name: | Go 6976 |
| Alternative Names: | |
| LINCS ID: | LSM-1211 |
| PubChem CID: | 3501 |
| ChEBI ID: | |
| ChEMBL ID: | 302449 |
| Molecular Mass: | 378.15 |
| InChi: | InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29) |
| InChi Key: | VWVYILCFSYNJHF-UHFFFAOYSA-N |
| SMILES: | CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
AIM1, AURKA, AURKB, BLK, CDK1, CDK2, CDK5, CHEK2, EGFR, FLT3, GSK3A, GSK3B, IRAK4, ITK, JAK3, LIMK1, MAPK8, MARK2, MARK3, PAK4, PDK1, PDPK1, PKD1, PKD2, PLK4, PRKACA, Prkca, PRKCA, Prkcb, PRKCB, Prkcd, Prkce, Prkcg, PRKCG, Prkch, Prkcq, Prkcz, PRKD1, PRKD2, ROCK1, RPS6KA3, RPS6KB1, TYK2 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | ABL1, DYRK1A, ERBB2, FGFR1, FLG, FLT1, FLT4, FYN, JAK2, KDR, LYN, MAPK1, PIM1, PRKCD, ROCK2 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | AKT1, AKT2, CAMK1, CHUK, CSF1R, CSNK1D, CSNK2A1, DAPK3, EPHA2, ERBB4, FGFR3, IGF1R, IKBKB, INSR, KIT, LCK, MAPK12, MAPK13, MAPK9, MAPKAPK2, MET, MYLK, PIM2, PLK1, PLK3, PRKCZ, PRKG1, SRC |
10 (confirmed non-binding) |
Batch Information for HMSL10210-101-1:
| HMS LINCS Batch ID: | 10210-101-1 |
| Provider: | EMD Millipore |
| Provider Batch ID: | EMD B64160 BIN: 65/0121404A1 |
| Salt: | 101 |
| Molecular Formula: | C24H18N4O |
| Molecular Weight: | 378.4 |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2011-07-15 |
| Most Recent Update: | 2016-08-11 |
(Kd <100 nM)