Cabozantinib - Small Molecule (ID:10194-106)

HMS LINCS ID: 10194-106
Name: Cabozantinib
Alternative Names: XL-184; BMS-907351
LINCS ID: LSM-1195
PubChem CID: 25102847
ChEBI ID:
ChEMBL ID:
Molecular Mass: 501.17
InChi: InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)
InChi Key: ONIQOQHATWINJY-UHFFFAOYSA-N
SMILES: COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
KDR, KIT, MET, RET
2
(equivalent to 100 nM ≤ Kd < 1µM)
AXL, FLT1, FLT3, FLT4, MERTK, NTRK2, ROS1, TEK, TYRO3

Batch Information for HMSL10194-106-2:

HMS LINCS Batch ID: 10194-106-2
Provider: MedChem Express
Provider Batch ID: 09581
Salt: 106
Molecular Formula: C32H30FN3O10
Molecular Weight: 635.59
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2015-06-17
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10194-106-2:

Date HMS QC Outcome Comment Files
08/31/2015 PASS HMSL10194-106-2_LCMS.pdf