Ki20227 - Small Molecule (ID:10187-101)

HMS LINCS ID: 10187-101
Name: Ki20227
Alternative Names:
LINCS ID: LSM-1188
PubChem CID: 57345770
ChEBI ID:
ChEMBL ID:
Molecular Mass: 480.15
InChi: InChI=1S/C24H24N4O5S/c1-14(23-12-25-13-34-23)27-24(29)28-17-6-5-15(9-20(17)30-2)33-19-7-8-26-18-11-22(32-4)21(31-3)10-16(18)19/h5-14H,1-4H3,(H2,27,28,29)
InChi Key: ZATITKHAYUKSBY-UHFFFAOYSA-N
SMILES: CC(C1=CN=CS1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)OC
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
CSF1R, DDR1, DDR2, EPHB6, KDR, KIT, MAP2K5, PDGFRA, PDGFRB, PTK6, SLK, STK10
2
(equivalent to 100 nM ≤ Kd < 1µM)
ABL1, ABL2, AURKB, AURKC, AXL, BLK, CSNK1E, FLT1, FLT4, FRK, HCK, LCK, LIMK2, LYN, MERTK, MET, PLK4, RIPK2, SRMS, TGFBR2, TNK2, TPTEP2-CSNK1E
3
(equivalent to 1µM ≤ Kd < 10 µM)
AURKA, BMPR1B, BTK, CSK, EGFR, EPHA1, EPHA8, ERBB4, FGR, FLT3, FYN, GAK, HIPK4, IRAK3, MAP2K1, MAP2K2, MAP3K19, MAP3K20, MAP4K5, MINK1, MST1R, NEK11, NLK, PF3D7_0217500, RET, SRC, STK4, TESK1, TNIK, TYRO3, YES1

Batch Information for HMSL10187-101-1:

HMS LINCS Batch ID: 10187-101-1
Provider: Haoyuan chemexpress
Provider Batch ID: HY-10408_1-20110628
Salt: 101
Molecular Formula: C24H24N4O5S
Molecular Weight: 480.54
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2011-07-15
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10187-101-1:

Date HMS QC Outcome Comment Files
04/13/2015 PASS HMSL10187-101-1_LCMS.pdf
11/14/2011 PASS None