Sunitinib - Small Molecule (ID:10175-999)

HMS LINCS ID: 10175-999
Name: Sunitinib
Alternative Names: Sutent; SU11248
LINCS ID: LSM-42800
PubChem CID: 3086686
ChEBI ID:
ChEMBL ID: 535
Molecular Mass: 398.21
InChi: InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)
InChi Key: WINHZLLDWRZWRT-UHFFFAOYSA-N
SMILES: CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2018-03-30

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
AAK1, AXL, BLK, BMP2K, CAMK2A, CHEK2, CLK1, CLK2, CLK4, CSF1R, CSNK1A1, CSNK1D, CSNK1E, DAPK3, FLT1, FLT3, FLT4, GAK, HIPK1, HIPK2, HIPK3, IRAK1, IRAK4, ITK, JAK1, KDR, KIT, LRRK2, MAP2K5, MAP3K13, MAP3K19, MAP3K2, MAP3K7, MAP4K1, MAP4K2, MAP4K5, MERTK, MINK1, MST1, MYLK2, MYLK3, MYLK4, NUAK1, PAK3, PDGFRA, PDGFRB, PHKG1, PHKG2, PIP4K2B, pknB, PRKAA1, PRKAA2, PTK2B, RET, RIOK1, RIOK2, RPS6KA2, RPS6KB1, SLK, SRPK3, STK10, STK11, STK17A, STK24, STK3, STK33, STK4, TNIK, TPTEP2-CSNK1E, TTK, TYRO3, ULK1, ULK2, ULK3
2
(equivalent to 100 nM ≤ Kd < 1µM)
ABL1, AIM1, ALK, ANKK1, AURKB, AURKC, BMPR2, C8orf44-SGK3, CAMK1, CAMK1D, CAMK1G, CAMK2D, CAMK2G, CAMK4, CAMKK1, CDK14, CDK16, CDK7, CHEK1, CHUK, CSNK1A1L, CSNK1D, CSNK1G1, CSNK1G2, CSNK1G3, CSNK2A1, CSNK2A2, DAPK1, DAPK2, DCLK1, DCLK3, DLK1, DYRK1A, DYRK2, EIF2AK2, EIF2AK4, EPHA6, EPHB1, EPHB6, ERN1, FES, FGFR1, FGFR2, FGFR3, FGR, FLG, FRK, FYN, GCK, GRK1, GRK4, GRK7, HCK, HIPK4, HUNK, ICK, IGF1R, IKBKE, INSR, INSRR, IRAK3, JAK2, KCNH2, LATS1, LATS2, LCK, LYN, MAP2K1, MAP2K1, MAP2K2, MAP2K4, MAP3K11, MAP3K12, MAP3K3, MAP4K3, MAP4K4, MARK2, MARK3, MAST1, MELK, MUSK, MYLK, NIM1K, NTRK1, NTRK2, NUAK2, OSR1, OXSR1, PAK5, PHKA2, PKD1, PKD2, PKN1, PLK4, PRKAB1, PRKAB2, PRKD1, PRKD2, PRKD3, PRPF4, PRPF4B, PTK2, RIPK1, ROCK1, ROCK2, RPS6KA1, RPS6KA3, RPS6KA4, RPS6KA5, SBK1, SGK2, SGK3, SIK2, SNRK, SRC, SRPK1, SRPK2, STK16, STK17B, STK25, STK26, Stk3, STK38, STK38L, STK39, TAOK1, TAOK3, TBK1, TLK1, TLK2, TNK1, TSSK2, TYK2, Ulk3, YES1
3
(equivalent to 1µM ≤ Kd < 10 µM)
ABL2, AKT2, AURKA, BMPR1B, BRSK1, BRSK2, BTK, BUB1B-PAK6, CAMK2B, CAMKK2, CDC7, CDK1, CDK17, CDK18, CDK4, CDK5, CDKL2, CIT, DCLK2, DDR1, DDR2, DSTYK, DYRK1B, DYRK3, DYRK4, EEF2K, EGFR, EPHA3, EPHA5, EPHA7, EPHB4, FER, FGFR4, GRK5, JAK3, LTK, MAP2K3, MAP2K6, MAP3K15, MAP3K4, MAP3K9, MAPK10, MAPK7, MAPK9, MARK1, MARK4, MATK, MET, MKNK1, MKNK2, MYO3A, MYO3B, NEK2, NEK4, NEK7, NTRK3, PAK4, PAK6, PDK1, PDPK1, PF3D7_0217500, PIM3, PIP5K1A, PKN2, PLK2, PRKCA, PRKCG, PRKCI, PRKCQ, PRKCZ, PTK6, RIOK3, RIPK4, RPS6KA6, SBK3, SIK1, SIK1B, SRC, STK35, TIE1, TNK2, TNKS2, TSSK1B, WEE1
10
(confirmed non-binding)
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Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20179
Sunitinib KINOMEscan
KINOMEscan

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10175-999-5