Doramapimod - Small Molecule (ID:10169-101)

HMS LINCS ID: 10169-101
Name: Doramapimod
Alternative Names: BIRB 796
LINCS ID: LSM-1170
PubChem CID: 156422
ChEBI ID:
ChEMBL ID:
Molecular Mass: 527.29
InChi: InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
InChi Key: MVCOAUNKQVWQHZ-UHFFFAOYSA-N
SMILES: CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
DDR1, DDR2, HSPB1, MAP4K4, MAPK11, MAPK12, MAPK13, Mapk14, MAPK14, MAPK9, STK10, TEK, TIE1, TKT
2
(equivalent to 100 nM ≤ Kd < 1µM)
BLK, CDC42BPB, CDK19, CDK8, EPHA3, EPHA7, EPHA8, EPHB2, FLT1, KIT, MAP3K20, MAP3K7, MAPK10, MINK1, NTRK2, NTRK3, PTK2B, RET, SLK, TNIK
3
(equivalent to 1µM ≤ Kd < 10 µM)
ABL1, ABL2, ANKK1, BRAF, CDC42BPA, CDC42BPG, CDK13, CDK5, CDK7, CHUK, CIT, CSF1R, DYRK1A, EGFR, EPHA1, EPHA2, EPHA4, EPHA5, EPHA6, EPHB1, FGFR1, FLG, FLT3, FLT4, FRK, HCK, KDR, LCK, LTK, LYN, MAP4K2, MAPK1, MAPK15, MAPK8, MERTK, MKNK1, MKNK2, MUSK, NLK, NTRK1, PDGFRA, PDGFRB, PRKCD, PRKCZ, PTK2, RAF1, RIPK2, SGK2, TAOK1, TTK, YES1
10
(confirmed non-binding)
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Batch Information for HMSL10169-101-1:

HMS LINCS Batch ID: 10169-101-1
Provider: Haoyuan chemexpress
Provider Batch ID: HY-10320_1-20101214
Salt: 101
Molecular Formula: C31H37N5O3
Molecular Weight: 527.66
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2011-07-15
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10169-101-1:

Date HMS QC Outcome Comment Files
04/13/2015 PASS HMSL10169-101-1_LCMS.pdf
11/14/2011 PASS None