Foretinib - Small Molecule (ID:10157-999)

HMS LINCS ID: 10157-999
Name: Foretinib
Alternative Names: XL880; GSK1363089
LINCS ID: LSM-1158
PubChem CID: 42642645
ChEBI ID:
ChEMBL ID:
Molecular Mass: 632.24
InChi: InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
InChi Key: CXQHYVUVSFXTMY-UHFFFAOYSA-N
SMILES: COC1=CC2=C(C=CN=C2C=C1OCCCN3CCOCC3)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-07-12

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
ABL1, ABL2, AIM1, ALK, AURKB, AURKC, AXL, BLK, BTK, CDK14, CDK15, CDK19, CDK7, CHEK2, CSF1R, DDR1, DDR2, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FER, FGR, FLT1, FLT3, FLT4, FRK, FYN, HCK, HIPK3, HIPK4, INSRR, ITK, KDR, KIT, LCK, LYN, MAP2K1, MAP2K2, MAP2K5, MAP3K12, MAP3K13, MAP3K19, MAP3K20, MAP4K1, MAP4K5, MAPK13, MAPK15, MERTK, MET, MKNK1, MKNK2, MST1R, MUSK, NTRK1, NTRK2, NTRK3, PDGFRA, PDGFRB, PIP4K2C, PLK4, PTK2B, PTK6, RET, RIPK2, ROS1, SLK, SRC, SRMS, STK10, STK33, TEK, TIE1, TKT, TNK1, TYRO3, YES1
2
(equivalent to 100 nM ≤ Kd < 1µM)
AURKA, BMX, CAMKK1, CDC42BPA, CDC42BPB, CDC42BPG, CDK11A, CDK11B, CDK13, CDK16, CDK17, CDK18, CDK8, CDKL2, CLK1, CLK4, CSK, DSTYK, EGFR, EIF2AK1, ERBB2, ERBB4, FES, FGFR1, FGFR2, FLG, FPGT-TNNI3K, HIPK1, HIPK2, IGF1R, INSR, IRAK3, LIMK1, LTK, MAP3K10, MAP3K11, MAP3K7, MAP4K3, MAP4K4, MAPK11, MAPK12, MAPK14, MAPK9, MELK, MYO3B, NEK8, NEK9, NLK, PF3D7_0217500, PRKAA1, PTK2, RIPK1, RIPK4, SIK1, SIK1B, SIK2, STK35, STK36, SYK, TBK1, TEC, TESK1, TNIK, TNK2, TNNI3K, TTK, TXK, ULK3
3
(equivalent to 1µM ≤ Kd < 10 µM)
ANKK1, BRAF, CAMK1, CAMK1D, CAMKK2, CDK9, CDKL3, CDKL5, CHUK, CIT, CSNK1E, CSNK2A2, DAPK3, DYRK2, ERBB3, FGFR3, HUNK, IKBKE, JAK2, LIMK2, MAK, MAP3K2, MAP3K3, MAP3K4, MAP3K9, MAP4K2, MAPK10, MAPK8, MINK1, MST1, MYLK2, MYLK3, MYO3A, PAK3, PRKAA2, PRKD3, RAF1, ROCK2, RPS6KA2, RPS6KB1, STK25, STK4, TAOK1, TAOK2, TPTEP2-CSNK1E, TYK2
10
(confirmed non-binding)
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Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20176
GSK-1363089 KINOMEscan
KINOMEscan

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10157-999-3